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565780 Sigma-Aldrichβ-Secretase Inhibitor III - Calbiochem

The β-Secretase Inhibitor III controls the biological activity of β-Secretase. This small molecule/inhibitor is primarily used for Neuroscience applications.

β-Secretase Inhibitor III - Calbiochem MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.

MSDS
分析证书
参考
Data Sheet

同义词: Inhibitor GL189, H-EVNstatineVAEF-NH₂

Primary Target: BACE

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概述

Replacement Information

重要规格表

Empirical Formula
C₄₄H₇₀N₁₀O₁₄

价格及供货情况

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Description
Overview	A substrate analog inhibitor of β-secretase (BACE) that completely blocks the proteolytic activity (at 5 µM) in solubilized membrane fractions from BACE transfected MDCK cells.
Catalogue Number	565780
Brand Family	Calbiochem®
Synonyms	Inhibitor GL189, H-EVNstatineVAEF-NH₂

References
References	Capell, A., et al. 2002. J. Biol. Chem. 277, 5637. Tung, J.S., et al. 2002. J. Med. Chem. 45, 259.

Product Information
ATP Competitive	N
Form	Lyophilized
Formulation	Supplied as a trifluoroacetate salt.
Hill Formula	C₄₄H₇₀N₁₀O₁₄
Chemical formula	C₄₄H₇₀N₁₀O₁₄
Hygroscopic	Hygroscopic
Reversible	N
Quality Level	MQ100

Applications

Biological Information
Primary Target	BACE
Primary Target IC<sub>50</sub>	Effective concentration: 5 µM completely blocking the proteolytic activity of β-secretase (BACE) in solubilized membrane fractions from BACE transfected MDCK cells
Purity	≥95% by HPLC

Physicochemical Information
Cell permeable	N
Peptide Sequence	H-Glu-Val-Asn-Statine-Val-Ala-Glu-Phe-NH₂

Dimensions

Materials Information

Toxicological Information

Safety Information according to GHS

Safety Information

Product Usage Statements

Storage and Shipping Information
Ship Code	Ambient Temperature Only
Toxicity	Standard Handling
Storage	-20°C
Hygroscopic	Hygroscopic
Do not freeze	Ok to freeze
Special Instructions	Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.

Packaging Information
Packaged under inert gas	Packaged under inert gas

Transport Information

Supplemental Information

Specifications

Global Trade Item Number
产品目录编号	GTIN
565780-500UGCN	04055977267280

Documentation

β-Secretase Inhibitor III - Calbiochem MSDS

职位
物料安全数据表 (MSDS)

β-Secretase Inhibitor III - Calbiochem 分析证书

标题	批号
565780	输入批号

参考

参考信息概述
Capell, A., et al. 2002. J. Biol. Chem. 277, 5637. Tung, J.S., et al. 2002. J. Med. Chem. 45, 259.

数据表

Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

Revision	10-September-2008 RFH
Synonyms	Inhibitor GL189, H-EVNstatineVAEF-NH₂
Description	A substrate analog inhibitor of β-secretase (BACE) that completely blocks proteolytic activity in solubilized membrane fractions of BACE-transfected MDCK cells at a concentration of 5 µM.
Form	Lyophilized
Formulation	Supplied as a trifluoroacetate salt.
Intert gas (Yes/No)	Packaged under inert gas
Chemical formula	C₄₄H₇₀N₁₀O₁₄
Peptide Sequence	H-Glu-Val-Asn-Statine-Val-Ala-Glu-Phe-NH₂
Purity	≥95% by HPLC
Solubility	DMSO (1 mg/ml)
Storage	-20°C Hygroscopic
Do Not Freeze	Ok to freeze
Special Instructions	Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
Toxicity	Standard Handling
References	Capell, A., et al. 2002. J. Biol. Chem. 277, 5637. Tung, J.S., et al. 2002. J. Med. Chem. 45, 259.

种类

Life Science Research > Inhibitors and Biochemicals > Small Molecules & Inhibitors > Neurobiology / Neurodegeneration > Secretase Inhibitors

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