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565755 Sigma-Aldrichγ-Secretase Inhibitor II - Calbiochem

The γ-Secretase Inhibitor II controls the biological activity of γ-Secretase. This small molecule/inhibitor is primarily used for Neuroscience applications.

γ-Secretase Inhibitor II - Calbiochem MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.

MSDS
分析证书
参考
Data Sheet

同义词: MW167

Primary Target: γ-secretase

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概述

Replacement Information

重要规格表

Empirical Formula
C₃₃H₅₇F₂N₅O₉

价格及供货情况

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Description
Overview	A cell-permeable, reversible and selective peptidomimetic inhibitor of γ-secretase (IC₅₀ = 13 µM for Aβ). Displays only weak inhibitory activity against calpain II (IC₅₀ = 100 µM in a purified enzyme assay). Please note that the molecular weight for this compound is batch-specific due to variable water content.
Catalogue Number	565755
Brand Family	Calbiochem®
Synonyms	MW167

References
References	Wolfe, M.S., et al. 1999. Biochemistry 38, 4720. Wolfe, M.S., et al. 1998. J. Med. Chem. 41, 6. Citron, M., et al. 1996. Proc. Natl. Acad. Sci. USA 93, 13170.

Product Information
ATP Competitive	N
Form	White solid
Hill Formula	C₃₃H₅₇F₂N₅O₉
Chemical formula	C₃₃H₅₇F₂N₅O₉
Reversible	Y
Structure formula Image
Quality Level	MQ100

Applications

Biological Information
Primary Target	γ-secretase
Primary Target IC<sub>50</sub>	13 µM against γ-secretase
Purity	≥95% by HPLC

Physicochemical Information
Cell permeable	Y

Dimensions

Materials Information

Toxicological Information

Safety Information according to GHS

Safety Information

Product Usage Statements

Storage and Shipping Information
Ship Code	Ambient Temperature Only
Toxicity	Standard Handling
Storage	-20°C
Do not freeze	Ok to freeze
Special Instructions	Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.

Packaging Information

Transport Information

Supplemental Information

Specifications

Global Trade Item Number
产品目录编号	GTIN
565755-1MGCN	04055977267693

Documentation

γ-Secretase Inhibitor II - Calbiochem MSDS

职位
物料安全数据表 (MSDS)

γ-Secretase Inhibitor II - Calbiochem 分析证书

标题	批号
565755	输入批号

参考

参考信息概述
Wolfe, M.S., et al. 1999. Biochemistry 38, 4720. Wolfe, M.S., et al. 1998. J. Med. Chem. 41, 6. Citron, M., et al. 1996. Proc. Natl. Acad. Sci. USA 93, 13170.

数据表

Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

Revision	21-November-2014 JSW
Synonyms	MW167
Description	A cell-permeable, reversible and selective peptidomimetic inhibitor of γ-secretase with an IC₅₀ of 13 µM for the inhibition of amyloid β-protein (Aβ) production in β-amyloid precursor protein (APP)-transfected Chinese hamster ovary cells. Displays only weak inhibitory activity against calpain II (IC₅₀ = 100 µM in a purified enzyme assay).
Form	White solid
Chemical formula	C₃₃H₅₇F₂N₅O₉
Structure formula
Purity	≥95% by HPLC
Solubility	DMSO (10 mM)
Storage	-20°C
Do Not Freeze	Ok to freeze
Special Instructions	Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.
Toxicity	Standard Handling
References	Wolfe, M.S., et al. 1999. Biochemistry 38, 4720. Wolfe, M.S., et al. 1998. J. Med. Chem. 41, 6. Citron, M., et al. 1996. Proc. Natl. Acad. Sci. USA 93, 13170.

种类

Life Science Research > Inhibitors and Biochemicals > Small Molecules & Inhibitors > Neurobiology / Neurodegeneration > Secretase Inhibitors

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