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			96-Well Plate

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565749 Sigma-Aldrichβ-Secretase Inhibitor II - CAS 263563-09-3 - Calbiochem

The β-Secretase Inhibitor II, also referenced under CAS 263563-09-3, controls the biological activity of β-Secretase. This small molecule/inhibitor is primarily used for Neuroscience applications.

MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.

MSDS
分析证书
参考
Data Sheet

同义词: Z-VLL-CHO, N-Benzyloxycarbonyl-Val-Leu-leucinal

Primary Target: β-secretase

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概述

Replacement Information

重要规格表

CAS #	Empirical Formula
263563-09-3	C₂₅H₃₉N₃O₅

价格及供货情况

产品目录编号	库存情况	包装	数量 / 包装	价格	数量
565749-1MGCN	正在查询供货情况...... — 目前缺货有货停产少量现货供货情况有待确认登录查看库存有货目前缺货有货其余：另行通知其余：另行通知另行通知联系客户服务 Contact Customer Service 联系客户服务联系客户服务	塑胶安瓿;塑胶针药瓶	1 mg	正在检索价格...... 无法检索价格。最小订购数量为倍数 Maximum Quantity is 以订单确认为准更多信息您节约了 ()。 — Request Pricing 登录查看价格	查看库存情况 —	添加到收藏夹添加到收藏夹添加到我的收藏夹
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Description
Overview	A potent, cell-permeable, and reversible inhibitor of β-secretase. Corresponds to the β-secretase cleavage site (VNL-DA) of the Swedish mutant Amyloid Precursor Protein (APP). Inhibits the formation of both Aβ_total(IC₅₀ = 700 nM) and Aβ_1-42 (IC₅₀ = 2.5 µM) in Chinese hamster ovary (CHO) cells stable transfected with wild-type APP751.
Catalogue Number	565749
Brand Family	Calbiochem®
Synonyms	Z-VLL-CHO, N-Benzyloxycarbonyl-Val-Leu-leucinal

References
References	Abbenante, G., et al. 2000. Biochem. Biophys. Res. Commun. 268, 133.

Product Information
CAS number	263563-09-3
ATP Competitive	N
Form	White solid
Hill Formula	C₂₅H₃₉N₃O₅
Chemical formula	C₂₅H₃₉N₃O₅
Reversible	Y
Structure formula Image
Quality Level	MQ100

Applications

Biological Information
Primary Target	β-secretase
Primary Target IC<sub>50</sub>	700 nM and 2.5 µM against Aβtotal and Aβ1-42, respectively
Purity	≥95% by HPLC

Physicochemical Information
Cell permeable	Y
Peptide Sequence	Z-Val-Leu-Leu-CHO

Dimensions

Materials Information

Toxicological Information

Safety Information according to GHS

Safety Information

Product Usage Statements

Storage and Shipping Information
Ship Code	Ambient Temperature Only
Toxicity	Standard Handling
Storage	-20°C
Protect from Light	Protect from light
Do not freeze	Ok to freeze
Special Instructions	Following reconstitution, aliquot and freeze at -20°C. Stock solutions are stable for up to 3 months at -20°C.

Packaging Information
Packaged under inert gas	Packaged under inert gas

Transport Information

Supplemental Information

Specifications

Global Trade Item Number
产品目录编号	GTIN
565749-1MGCN	04055977267655
565749-5MGCN	04055977267662

Documentation

β-Secretase Inhibitor II - CAS 263563-09-3 - Calbiochem MSDS

职位
物料安全数据表 (MSDS)

β-Secretase Inhibitor II - CAS 263563-09-3 - Calbiochem 分析证书

标题	批号
565749	输入批号

参考

参考信息概述
Abbenante, G., et al. 2000. Biochem. Biophys. Res. Commun. 268, 133.

数据表

Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

Revision	04-April-2011 RFH
Synonyms	Z-VLL-CHO, N-Benzyloxycarbonyl-Val-Leu-leucinal
Description	A potent, cell-permeable, and reversible inhibitor of β-secretase that corresponds to the β-secretase cleavage site (VNL-DA) of the Swedish mutant Amyloid Precursor Protein (APP). Inhibits the formation of both Aβ_total (IC₅₀ = 700 nM) and Aβ_1-42 (IC₅₀ = 2.5 µM) in Chinese hamster ovary (CHO) cells stably transfected with wild-type APP751.
Form	White solid
Intert gas (Yes/No)	Packaged under inert gas
CAS number	263563-09-3
Chemical formula	C₂₅H₃₉N₃O₅
Peptide Sequence	Z-Val-Leu-Leu-CHO
Structure formula
Purity	≥95% by HPLC
Solubility	DMSO (5 mg/ml)
Storage	Protect from light -20°C
Do Not Freeze	Ok to freeze
Special Instructions	Following reconstitution, aliquot and freeze at -20°C. Stock solutions are stable for up to 3 months at -20°C.
Toxicity	Standard Handling
References	Abbenante, G., et al. 2000. Biochem. Biophys. Res. Commun. 268, 133.

种类

Life Science Research > Inhibitors and Biochemicals > Small Molecules & Inhibitors > Neurobiology / Neurodegeneration > Secretase Inhibitors

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