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			96-Well Plate

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	48-602MAG	Buffer Detection Kit for Magnetic Beads	1 Kit

565750 Sigma-Aldrichγ-Secretase Inhibitor I - Calbiochem

The γ-Secretase Inhibitor I controls the biological activity of γ-Secretase. This small molecule/inhibitor is primarily used for Neuroscience applications.

γ-Secretase Inhibitor I - Calbiochem MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.

MSDS
分析证书
参考
Data Sheet

同义词: Z-LLNle-CHO

Primary Target: γ-secretase

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概述

Replacement Information

重要规格表

Empirical Formula
C₂₆H₄₁N₃O₅

价格及供货情况

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Description
Overview	Cell permeable. Inhibits γ-secretase, a protease that cleaves the Amyloid Precursor Protein (APP) to generate β-amyloid protein. Inhibition of this enzyme is believed to aid in the prevention of Alzheimer’s disease.
Catalogue Number	565750
Brand Family	Calbiochem®
Synonyms	Z-LLNle-CHO

References
References	Skovronsky, D.M., et al. 2000. Biochemistry 39, 810. Hartmann, T., et al. 1997. Nat. Med. 3, 1016.

Product Information
ATP Competitive	N
Form	White solid
Hill Formula	C₂₆H₄₁N₃O₅
Chemical formula	C₂₆H₄₁N₃O₅
Hygroscopic	Hygroscopic
Reversible	N
Structure formula Image
Quality Level	MQ200

Applications

Biological Information
Primary Target	γ-secretase
Purity	≥90% by HPLC

Physicochemical Information
Cell permeable	Y
Peptide Sequence	Z-Leu-Leu-Nle-CHO (Nle = Norleucine)

Dimensions

Materials Information

Toxicological Information

Safety Information according to GHS

Safety Information

Product Usage Statements

Storage and Shipping Information
Ship Code	Ambient Temperature Only
Toxicity	Standard Handling
Storage	-20°C
Hygroscopic	Hygroscopic
Do not freeze	Ok to freeze
Special Instructions	Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.

Packaging Information
Packaged under inert gas	Packaged under inert gas

Transport Information

Supplemental Information

Specifications

Global Trade Item Number
产品目录编号	GTIN
565750-1MGCN	04055977267679

Documentation

γ-Secretase Inhibitor I - Calbiochem MSDS

职位
物料安全数据表 (MSDS)

γ-Secretase Inhibitor I - Calbiochem 分析证书

标题	批号
565750	输入批号

参考

参考信息概述
Skovronsky, D.M., et al. 2000. Biochemistry 39, 810. Hartmann, T., et al. 1997. Nat. Med. 3, 1016.

数据表

Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

Revision	07-January-2009 RFH
Synonyms	Z-LLNle-CHO
Description	Inhibits γ-secretase, a protease that cleaves the amyloid precursor protein (APP). Inhibition of this enzyme is believed to aid in the prevention of Alzheimer's disease.
Form	White solid
Intert gas (Yes/No)	Packaged under inert gas
Chemical formula	C₂₆H₄₁N₃O₅
Peptide Sequence	Z-Leu-Leu-Nle-CHO (Nle = Norleucine)
Structure formula
Purity	≥90% by HPLC
Solubility	50% acetic acid or DMSO (10 mg/ml)
Storage	-20°C Hygroscopic
Do Not Freeze	Ok to freeze
Special Instructions	Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
Toxicity	Standard Handling
References	Skovronsky, D.M., et al. 2000. Biochemistry 39, 810. Hartmann, T., et al. 1997. Nat. Med. 3, 1016.

种类

Life Science Research > Inhibitors and Biochemicals > Small Molecules & Inhibitors > Neurobiology / Neurodegeneration > Secretase Inhibitors

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