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401003 Sigma-Aldrich(±)-Ibuprofen - CAS 15687-27-1 - Calbiochem

A nonsteroidal anti-inflammatory drug (NSAID) that acts as a reversible and competitive inhibitor of cyclooxygenase 1 (COX-1) (IC₅₀ = 4.85 µM).

(±)-Ibuprofen - CAS 15687-27-1 - Calbiochem MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.

MSDS
分析证书
参考
Data Sheet

同义词: [(±)-2-(4-Isobutylphenyl)-propionic Acid

Primary Target: COX-1

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概述

Replacement Information

重要规格表

CAS #	Empirical Formula
15687-27-1	C₁₃H₁₈O₂

价格及供货情况

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Description
Overview	A nonsteroidal anti-inflammatory drug (NSAID) that acts as a reversible and competitive inhibitor of cyclooxygenase 1 (COX-1) (IC₅₀ = 4.85 µM). Inhibits COX-2 at higher concentrations (IC₅₀ = 223 µM). Blocks aspirin inactivation of COX-1 (EC₅₀ antagonism of 200 µM aspirin = 290 nM). Shown to reduce the total Aβ secretion (Amyloid β_{40 and 42}) in human neuronal cells and offers neuroprotection against glutamate-, nitric oxide-, and superoxide-induced damage. Reported to activate peroxisome proliferator-activated receptors (PPAR) α and γ in both CV-1 and C3H10T1/2 cells (~100 µM-500 µM).
Catalogue Number	401003
Brand Family	Calbiochem®
Synonyms	[(±)-2-(4-Isobutylphenyl)-propionic Acid

References
References	Asanuma, M., et al. 2001. J. Neurochem. 76, 1895. Blasko, I., et al. 2001. Neurobiol. Dis. 8, 1094. Ouellet, M., et al. 2001. Proc. Natl. Acad. Sci. USA 98, 14583. Casper, D., et al. 2000. Neurosci. Lett. 289, 201. Lambat, Z., et al. 2000. Metab. Brain Dis. 15, 249. Lim, G.P., et al. 2000. J. Neurosci. 20, 5709. Ogawa, O., et al. 2000. Eur. J. Pharmacol. 408, 137. Wyss-Coray, T., and Mucke, L. 2000. Nat. Med. 6, 973. Lehmann, J.M., et al. 1997. J. Biol. Chem. 272, 3406. Boneburg, E.M., et al. 1996. J. Clin. Pharmacol. 36, 16S. Mitchell, J.A., et al. 1994. Proc. Natl. Acad. Sci. USA 90, 11693.

References

Asanuma, M., et al. 2001. J. Neurochem. 76, 1895.
Blasko, I., et al. 2001. Neurobiol. Dis. 8, 1094.
Ouellet, M., et al. 2001. Proc. Natl. Acad. Sci. USA 98, 14583.
Casper, D., et al. 2000. Neurosci. Lett. 289, 201.
Lambat, Z., et al. 2000. Metab. Brain Dis. 15, 249.
Lim, G.P., et al. 2000. J. Neurosci. 20, 5709.
Ogawa, O., et al. 2000. Eur. J. Pharmacol. 408, 137.
Wyss-Coray, T., and Mucke, L. 2000. Nat. Med. 6, 973.
Lehmann, J.M., et al. 1997. J. Biol. Chem. 272, 3406.
Boneburg, E.M., et al. 1996. J. Clin. Pharmacol. 36, 16S.
Mitchell, J.A., et al. 1994. Proc. Natl. Acad. Sci. USA 90, 11693.

Product Information
CAS number	15687-27-1
ATP Competitive	Y
Form	White solid
Hill Formula	C₁₃H₁₈O₂
Chemical formula	C₁₃H₁₈O₂
Reversible	Y
Structure formula Image
Quality Level	MQ100

Applications

Biological Information
Primary Target	COX-1
Primary Target IC<sub>50</sub>	4.85 µM against COX-1
Purity	≥98% by titration

Physicochemical Information
Cell permeable	N

Dimensions

Materials Information

Toxicological Information

Safety Information according to GHS
RTECS	MU6640000

Safety Information
R Phrase	R: 22 Harmful if swallowed.
S Phrase	S: 36 Wear suitable protective clothing.

Product Usage Statements

Storage and Shipping Information
Ship Code	Ambient Temperature Only
Toxicity	Harmful
Storage	+15°C to +30°C
Protect from Light	Protect from light
Do not freeze	Ok to freeze
Special Instructions	Following reconstitution aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.

Packaging Information

Transport Information

Supplemental Information

Specifications

Global Trade Item Number
产品目录编号	GTIN
401003-1GMCN	04055977189377

Documentation

(±)-Ibuprofen - CAS 15687-27-1 - Calbiochem MSDS

职位
物料安全数据表 (MSDS)

(±)-Ibuprofen - CAS 15687-27-1 - Calbiochem 分析证书

标题	批号
401003	输入批号

参考

参考信息概述
Asanuma, M., et al. 2001. J. Neurochem. 76, 1895. Blasko, I., et al. 2001. Neurobiol. Dis. 8, 1094. Ouellet, M., et al. 2001. Proc. Natl. Acad. Sci. USA 98, 14583. Casper, D., et al. 2000. Neurosci. Lett. 289, 201. Lambat, Z., et al. 2000. Metab. Brain Dis. 15, 249. Lim, G.P., et al. 2000. J. Neurosci. 20, 5709. Ogawa, O., et al. 2000. Eur. J. Pharmacol. 408, 137. Wyss-Coray, T., and Mucke, L. 2000. Nat. Med. 6, 973. Lehmann, J.M., et al. 1997. J. Biol. Chem. 272, 3406. Boneburg, E.M., et al. 1996. J. Clin. Pharmacol. 36, 16S. Mitchell, J.A., et al. 1994. Proc. Natl. Acad. Sci. USA 90, 11693.

参考信息概述

数据表

Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

Revision	28-April-2008 JSW
Synonyms	[(±)-2-(4-Isobutylphenyl)-propionic Acid
Description	A nonsteroidal anti-inflammatory drug (NSAID) that acts as a reversible, competitive, non-selective cyclooxygenase (COX) inhibitor (IC₅₀ = 4.85 µM for purified COX-1 and 223 µM for purified COX-2). Also reported to inhibit COX-1 and COX-2 activity in intact bovine aortic endothelial cells (BAEC) (IC₅₀ = 7 µM for COX-1 and 72.7 µM for COX-2). Potently blocks aspirin inactivation of COX-1 (EC₅₀ antagonism of 200 µM aspirin ~290 nM for ovine COX-1). Decreases the secretion of total Aβ (Amyloid β_40&42) by human neuronal cells and offers neuroprotection against glutamate-, nitric oxide- and superoxide-induced damage. Activates peroxisome proliferator activated receptors α and γ in both CV-1 and C3H10T1/2 cells (~100 µM - 500 µM).
Form	White solid
CAS number	15687-27-1
RTECS	MU6640000
Chemical formula	C₁₃H₁₈O₂
Structure formula
Purity	≥98% by titration
Solubility	DMSO (5 mg/ml) or Ethanol (1 mg/ml)
Storage	Protect from light +15°C to +30°C
Do Not Freeze	Ok to freeze
Special Instructions	Following reconstitution aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.
Toxicity	Harmful
Merck USA index	14, 4881
References	Asanuma, M., et al. 2001. J. Neurochem. 76, 1895. Blasko, I., et al. 2001. Neurobiol. Dis. 8, 1094. Ouellet, M., et al. 2001. Proc. Natl. Acad. Sci. USA 98, 14583. Casper, D., et al. 2000. Neurosci. Lett. 289, 201. Lambat, Z., et al. 2000. Metab. Brain Dis. 15, 249. Lim, G.P., et al. 2000. J. Neurosci. 20, 5709. Ogawa, O., et al. 2000. Eur. J. Pharmacol. 408, 137. Wyss-Coray, T., and Mucke, L. 2000. Nat. Med. 6, 973. Lehmann, J.M., et al. 1997. J. Biol. Chem. 272, 3406. Boneburg, E.M., et al. 1996. J. Clin. Pharmacol. 36, 16S. Mitchell, J.A., et al. 1994. Proc. Natl. Acad. Sci. USA 90, 11693.

种类

Life Science Research > Inhibitors and Biochemicals > Small Molecules & Inhibitors > Lipid Signaling Inhibitors > Cyclooxygenase (COX) Inhibitors

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