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219334 Sigma-Aldrichβ-Catenin/Tcf Inhibitor V, BC21 - CAS 691005-38-6 - Calbiochem

The β-Catenin/Tcf Inhibitor V, BC21, also referenced under CAS 691005-38-6, controls the biological activity of β-Catenin/Tcf. This small molecule/inhibitor is primarily used for Biochemicals applications.

MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.

MSDS
分析证书
参考
Data Sheet

同义词: Copper, di-µ-chlorobis[1-[(1-piperidinyl-κN)methyl]-2-naphthalenolato-κO]di-(9Cl), Wnt Pathway Inhibitor XV

Recommended Products

概述

Replacement Information

重要规格表

CAS #	Empirical Formula
691005-38-6	C₃₂H₃₆Cl₂Cu₂N₂O₂

价格及供货情况

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Description
Overview	A cell-permeable dimeric copper complex that competitively binds β-catenin and disrupts β-catenin/Tcf4 interaction reversibly (IC₅₀ = 5.0 µM), and acts as a Wnt signaling inhibitor. Shown to induce preferential growth arrest in β-catenin overexpressing HCT116 colon cancer and HEK293 cells (≤ 10 µM), and downregulate mRNA expressions of c-Myc and cyclin D1. Reported to inhibit PP2C and proteasomal activities at higher concentrations (~50 µM).
Catalogue Number	219334
Brand Family	Calbiochem®
Synonyms	Copper, di-µ-chlorobis[1-[(1-piperidinyl-κN)methyl]-2-naphthalenolato-κO]di-(9Cl), Wnt Pathway Inhibitor XV

References
References	Tian, W., et al. 2012. Biochemistry 51, 724. Rogers, J.P., et al. 2006. J. Med. Chem. 49, 1658. Daniel, K.G., et al. 2004. Biochem. Pharmacol. 67, 1139.

Product Information
CAS number	691005-38-6
Form	Dark brown solid
Hill Formula	C₃₂H₃₆Cl₂Cu₂N₂O₂
Chemical formula	C₃₂H₃₆Cl₂Cu₂N₂O₂
Structure formula Image
Quality Level	MQ100

Applications

Biological Information
Purity	≥95% by Elemental Analysis

Physicochemical Information

Dimensions

Materials Information

Toxicological Information

Safety Information according to GHS

Safety Information

Product Usage Statements

Storage and Shipping Information
Ship Code	Ambient Temperature Only
Toxicity	Standard Handling
Storage	+2°C to +8°C
Protect from Light	Protect from light
Do not freeze	Ok to freeze
Special Instructions	Following reconstitution aliquot, freeze (≥-70°C). Stock solutions are stable for up to 12 months at ≥-70°C.

Packaging Information
Packaged under inert gas	Packaged under inert gas

Transport Information

Supplemental Information

Specifications

Global Trade Item Number
产品目录编号	GTIN
219334-10MGCN	04055977202137

Documentation

β-Catenin/Tcf Inhibitor V, BC21 - CAS 691005-38-6 - Calbiochem MSDS

职位
物料安全数据表 (MSDS)

β-Catenin/Tcf Inhibitor V, BC21 - CAS 691005-38-6 - Calbiochem 分析证书

标题	批号
219334	输入批号

参考

参考信息概述
Tian, W., et al. 2012. Biochemistry 51, 724. Rogers, J.P., et al. 2006. J. Med. Chem. 49, 1658. Daniel, K.G., et al. 2004. Biochem. Pharmacol. 67, 1139.

数据表

Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

Revision	03-February-2017 JSW
Synonyms	Copper, di-µ-chlorobis[1-[(1-piperidinyl-κN)methyl]-2-naphthalenolato-κO]di-(9Cl), Wnt Pathway Inhibitor XV
Description	A cell-permeable dimeric copper complex that competitively binds β-catenin and disrupts β-catenin/Tcf4 interaction reversibly (IC₅₀ = 5.0 µM), and acts as a Wnt signaling inhibitor. Shown to induce preferential growth arrest in β-catenin overexpressing HCT116 colon cancer and HEK293 cells (≤ 10 µM), and downregulate mRNA expressions of c-Myc and cyclin D1. Reported to inhibit PP2C and proteasomal activities at higher concentrations (~50 µM).
Form	Dark brown solid
Intert gas (Yes/No)	Packaged under inert gas
CAS number	691005-38-6
Chemical formula	C₃₂H₃₆Cl₂Cu₂N₂O₂
Structure formula
Purity	≥95% by Elemental Analysis
Solubility	DMSO (0.5 mg/ml). Poorly soluble in water.
Storage	Protect from light +2°C to +8°C
Do Not Freeze	Ok to freeze
Special Instructions	Following reconstitution aliquot, freeze (≥-70°C). Stock solutions are stable for up to 12 months at ≥-70°C.
Toxicity	Standard Handling
References	Tian, W., et al. 2012. Biochemistry 51, 724. Rogers, J.P., et al. 2006. J. Med. Chem. 49, 1658. Daniel, K.G., et al. 2004. Biochem. Pharmacol. 67, 1139.

种类

Life Science Research > Inhibitors and Biochemicals > Small Molecules & Inhibitors > Wnt Signaling

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