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			96-Well Plate

数量	产品目录编号	订购说明	数量 / 包装	公开价
	48-602MAG	Buffer Detection Kit for Magnetic Beads	1 Kit

219332 Sigma-Aldrichβ-Catenin/Tcf Inhibitor III, iCRT3 - Calbiochem

The β-Catenin/Tcf Inhibitor III, iCRT3 controls the biological activity of β-Catenin/Tcf. This small molecule/inhibitor is primarily used for Biochemicals applications.

MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.

MSDS
分析证书
参考
Data Sheet

同义词: 2-(((2-(4-Ethylphenyl)-5-methyl-1,3-oxazol-4-yl)methyl)sulfanyl)-N-(2-phenylethyl)acetamide, Inhibitor of β-Catenin Responsive Transcription, Wnt Pathway Inhibitor VIII, C3

Recommended Products

概述

Replacement Information

重要规格表

Empirical Formula
C₂₃H₂₆N₂O₂S

价格及供货情况

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Description
Overview	A cell-permeable oxazole compound that acts as a selective CRT (β-catenin responsive transcription) inhibitor (IC₅₀ = 8.2 nM against Wnt3a-dependent SuperTopFlash STF16-luc reporter activity in HEK293 cultures) by interfering with β-cat-TCF4 interaction via direct β-catenin (β-cat) binding, while exhibiting much reduced activity against Hedgehog, Jak/Stat, or Notch signaling pathway-dependent transcription activation. Effectively inhibits cellular expression of CRT target genes, including WISP1, AXN2, and CYCD1, in a dose-dependent manner (25 to 75 µM), and selectively inhibits the proliferation of HCT116 (75 µM), HT29 (75 µM), and several primary human colon cancer cultures (6.25 to 100 µg/ml; average IC₅₀ ~36 µg/ml) that require sustained Wnt/CRT activity for survival.
Catalogue Number	219332
Brand Family	Calbiochem®
Synonyms	2-(((2-(4-Ethylphenyl)-5-methyl-1,3-oxazol-4-yl)methyl)sulfanyl)-N-(2-phenylethyl)acetamide, Inhibitor of β-Catenin Responsive Transcription, Wnt Pathway Inhibitor VIII, C3

References
References	Lee, E., et al. 2013. Proc. Natl. Acad. Sci. USA 110, 15710. Gonsalves, F.C., et al. 2011. Proc. Natl. Acad. Sci. USA 108, 5954.

Product Information
Form	Tan powder
Hill Formula	C₂₃H₂₆N₂O₂S
Chemical formula	C₂₃H₂₆N₂O₂S
Structure formula Image
Quality Level	MQ100

Applications

Biological Information
Purity	≥95% by HPLC

Physicochemical Information

Dimensions

Materials Information

Toxicological Information

Safety Information according to GHS

Safety Information

Product Usage Statements

Storage and Shipping Information
Ship Code	Shipped at Ambient Temperature or with Blue Ice or with Dry Ice
Toxicity	Standard Handling
Storage	-20°C
Protect from Light	Protect from light
Do not freeze	Ok to freeze
Special Instructions	Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.

Packaging Information
Packaged under inert gas	Packaged under inert gas

Transport Information

Supplemental Information

Specifications

Global Trade Item Number
产品目录编号	GTIN
219332-10MGCN	04055977202113

Documentation

β-Catenin/Tcf Inhibitor III, iCRT3 - Calbiochem MSDS

职位
物料安全数据表 (MSDS)

β-Catenin/Tcf Inhibitor III, iCRT3 - Calbiochem 分析证书

标题	批号
219332	输入批号

参考

参考信息概述
Lee, E., et al. 2013. Proc. Natl. Acad. Sci. USA 110, 15710. Gonsalves, F.C., et al. 2011. Proc. Natl. Acad. Sci. USA 108, 5954.

数据表

Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

Revision	11-October-2013 JSW
Synonyms	2-(((2-(4-Ethylphenyl)-5-methyl-1,3-oxazol-4-yl)methyl)sulfanyl)-N-(2-phenylethyl)acetamide, Inhibitor of β-Catenin Responsive Transcription, Wnt Pathway Inhibitor VIII, C3
Description	A cell-permeable oxazole compound that acts as a selective CRT (β-catenin responsive transcription) inhibitor (IC₅₀ = 8.2 nM against Wnt3a-dependent SuperTopFlash STF16-luc reporter activity in HEK293 cultures) by interfering with β-cat-TCF4 interaction via direct β-catenin (β-cat) binding, while exhibiting much reduced activity against Hedgehog, Jak/Stat, or Notch signaling pathway-dependent transcription activation. Effectively inhibits cellular expression of CRT target genes, including WISP1, AXN2, and CYCD1, in a dose-dependent manner (25 to 75 µM), and selectively inhibits the proliferation of HCT116 (75 µM), HT29 (75 µM), and several primary human colon cancer cultures (6.25 to 100 µg/ml; average IC₅₀ ~36 µg/ml) that require sustained Wnt/CRT activity for survival.
Form	Tan powder
Intert gas (Yes/No)	Packaged under inert gas
Chemical formula	C₂₃H₂₆N₂O₂S
Structure formula
Purity	≥95% by HPLC
Solubility	DMSO (50 mg/ml)
Storage	Protect from light -20°C
Do Not Freeze	Ok to freeze
Special Instructions	Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
Toxicity	Standard Handling
References	Lee, E., et al. 2013. Proc. Natl. Acad. Sci. USA 110, 15710. Gonsalves, F.C., et al. 2011. Proc. Natl. Acad. Sci. USA 108, 5954.

种类

Life Science Research > Inhibitors and Biochemicals > Small Molecules & Inhibitors > Wnt Signaling

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