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219330 Sigma-Aldrichβ-Catenin/Tcf Inhibitor, FH535 - CAS 108409-83-2 - Calbiochem

The β-Catenin/Tcf Inhibitor, FH535, also referenced under CAS 108409-83-2, controls the biological activity of β-Catenin/Tcf. This small molecule/inhibitor is primarily used for Cell Signaling applications.

MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.

MSDS
分析证书
参考
Data Sheet

同义词: Wnt Pathway Inhibitor IX, N-(2-Methyl-4-nitro)-2,4-dichlorosulfonamide

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概述

Replacement Information

重要规格表

CAS #	Empirical Formula
108409-83-2	C₁₃H₁₀Cl₂N₂O₄S

价格及供货情况

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Description
Overview	A cell-permeable sulfonamide compound that acts as a dual pathway inhibitor against Wnt/β-catenin (≥80% inhibition at 15 µM in β-catenin/Tcf-dependent cellular reporter assays) and PPARγ/δ (≥30% inhibition at 0.5 µM in PPRE cellular reporter assays) signalings. Although both FH535 and the structurally similar PPARγ-selective inhibitor GW9662 (Cat. No. 370700) inhibit coactivator/PPAR binding, only FH535 blocks β-catenin/PPARγ interaction and the antagonistic activity of FH535 does not involve the covalent modification of or non-covalent interaction with the PPAR ligand-binding site cystein residue that is crucial for GW9662 action.
Catalogue Number	219330
Brand Family	Calbiochem®
Synonyms	Wnt Pathway Inhibitor IX, N-(2-Methyl-4-nitro)-2,4-dichlorosulfonamide

References
References	Handeli, S., and Simon, J.A. 2008. Mol. Cancer Ther. 7, 521.

Product Information
CAS number	108409-83-2
Form	Yellow solid
Hill Formula	C₁₃H₁₀Cl₂N₂O₄S
Chemical formula	C₁₃H₁₀Cl₂N₂O₄S
Structure formula Image
Quality Level	MQ100

Applications

Biological Information
Purity	≥99% by HPLC

Physicochemical Information

Dimensions

Materials Information

Toxicological Information

Safety Information according to GHS

Safety Information

Product Usage Statements

Storage and Shipping Information
Ship Code	Ambient Temperature Only
Toxicity	Standard Handling
Storage	+2°C to +8°C
Protect from Light	Protect from light
Do not freeze	Ok to freeze
Special Instructions	Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.

Packaging Information
Packaged under inert gas	Packaged under inert gas

Transport Information

Supplemental Information

Specifications

Global Trade Item Number
产品目录编号	GTIN
219330-10MGCN	04055977202090

Documentation

β-Catenin/Tcf Inhibitor, FH535 - CAS 108409-83-2 - Calbiochem MSDS

职位
物料安全数据表 (MSDS)

β-Catenin/Tcf Inhibitor, FH535 - CAS 108409-83-2 - Calbiochem 分析证书

标题	批号
219330	输入批号

参考

参考信息概述
Handeli, S., and Simon, J.A. 2008. Mol. Cancer Ther. 7, 521.

数据表

Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

Revision	17-July-2014 JSW
Synonyms	Wnt Pathway Inhibitor IX, N-(2-Methyl-4-nitro)-2,4-dichlorosulfonamide
Description	A cell-permeable sulfonamide compound that acts as a dual pathway inhibitor against Wnt/β-catenin (≥80% inhibition at 15 µM in β-catenin/Tcf-dependent cellular reporter assays) and PPARγ/δ (≥30% inhibition at 0.5 µM in PPRE cellular reporter assays) signalings. Although both FH535 and the structurally similar PPARγ-selective inhibitor GW9662 (Cat. No. 370700) inhibit coactivator/PPAR binding, only FH535 blocks β-catenin/PPARγ interaction and the antagonistic activity of FH535 does not involve the covalent modification of or non-covalent interaction with the PPAR ligand-binding site cystein residue that is crucial for GW9662 action.
Form	Yellow solid
Intert gas (Yes/No)	Packaged under inert gas
CAS number	108409-83-2
Chemical formula	C₁₃H₁₀Cl₂N₂O₄S
Structure formula
Purity	≥99% by HPLC
Solubility	DMSO (100 mg/ml)
Storage	Protect from light +2°C to +8°C
Do Not Freeze	Ok to freeze
Special Instructions	Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
Toxicity	Standard Handling
References	Handeli, S., and Simon, J.A. 2008. Mol. Cancer Ther. 7, 521.

种类

Life Science Research > Inhibitors and Biochemicals > Small Molecules & Inhibitors > Stem Cell Biology > Wnt Signaling Inhibitors

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