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203390 Sigma-Aldrich(±)-Blebbistatin - CAS 674289-55-5 - Calbiochem

(±)-Blebbistatin, CAS 674289-55-5, is a cell-permeable, selective, and reversible inhibitor of nonmuscle myosin II. Blocks cell blebbing and disrupts cell migration & cytoKinesis in vertebrate cells.

MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.

MSDS
分析证书
参考
Data Sheet

Primary Target: ATPase

Recommended Products

概述

Replacement Information

重要规格表

CAS #	Empirical Formula
674289-55-5	C₁₈H₁₆N₂O₂

价格及供货情况

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Description
Overview	A cell-permeable compound that acts as a selective, potent, and reversible inhibitor of nonmuscle myosin II. Inhibits the ATPase and gliding motility of human platelets (≤ 100 µM) without affecting myosin light chain kinase (MLCK) activity. Has been shown to block cell blebbing and to rapidly disrupt directed cell migration and cytokinesis in vertebrate cells. Does not disrupt mitosis or affect contractile ring assembly. A 50 mM (5 mg/342 µl) solution of (±)-Blebbistatin (Cat. No. 203389) in 90% DMSO is also available.
Catalogue Number	203390
Brand Family	Calbiochem®

References
References	Shu, S., et al. 2005. Proc. Natl. Acad. Sci. USA 102, 1472. Kovacs, M., et al. 2004. J. Biol. Chem. 279, 35557. Straight, A.F., et al. 2003. Science 299, 1743. Cheung, A., et al. 2001. Mol. Biol. Cell Suppl. 12, 271a.

Product Information
CAS number	674289-55-5
ATP Competitive	N
Form	Yellow solid
Hill Formula	C₁₈H₁₆N₂O₂
Chemical formula	C₁₈H₁₆N₂O₂
Reversible	Y
Structure formula Image
Quality Level	MQ100

Applications

Biological Information
Primary Target	ATPase
Primary Target IC<sub>50</sub>	<100 µM inhibiting the ATPase and gliding motility of human platelets
Purity	≥97% by HPLC

Physicochemical Information
Cell permeable	Y

Dimensions

Materials Information

Toxicological Information

Safety Information according to GHS

Safety Information

Product Usage Statements

Storage and Shipping Information
Ship Code	Blue Ice Only
Storage	-20°C
Protect from Light	Protect from light
Do not freeze	Ok to freeze
Special Instructions	Following reconstitution in 90% DMSO, aliquot and freeze (-20°C). Stock solutions in 90% DMSO are stable for up to 1 month at -20°C. Stock solutions in 100% DMSO are unstable; reconstitute just prior to use.

Packaging Information
Packaged under inert gas	Packaged under inert gas

Transport Information

Supplemental Information

Specifications

Global Trade Item Number
产品目录编号	GTIN
203390-5MGCN	04055977221268

Documentation

(±)-Blebbistatin - CAS 674289-55-5 - Calbiochem MSDS

职位
物料安全数据表 (MSDS)

(±)-Blebbistatin - CAS 674289-55-5 - Calbiochem 分析证书

标题	批号
203390	输入批号

参考

参考信息概述
Shu, S., et al. 2005. Proc. Natl. Acad. Sci. USA 102, 1472. Kovacs, M., et al. 2004. J. Biol. Chem. 279, 35557. Straight, A.F., et al. 2003. Science 299, 1743. Cheung, A., et al. 2001. Mol. Biol. Cell Suppl. 12, 271a.

数据表

Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

Revision	31-March-2011 RFH
Description	A cell-permeable compound that acts as a selective, potent, and reversible inhibitor of non-muscle myosin II. Inhibits the ATPase and gliding motility of human platelets (≤100 µM) without affecting myosin light chain kinase (MLCK) activity. Has been shown to block cell blebbing and to rapidly disrupt directed cell migration and cytokinesis in vertebrate cells. Does not disrupt mitosis or affect contractile ring assembly.
Form	Yellow solid
Intert gas (Yes/No)	Packaged under inert gas
CAS number	674289-55-5
Chemical formula	C₁₈H₁₆N₂O₂
Structure formula
Purity	≥97% by HPLC
Solubility	100% DMSO (100 mg/ml), 90% DMSO (75 mg/ml) or Methanol (1.5 mg/ml)
Storage	Protect from light -20°C
Do Not Freeze	Ok to freeze
Special Instructions	Following reconstitution in 90% DMSO, aliquot and freeze (-20°C). Stock solutions in 90% DMSO are stable for up to 1 month at -20°C. Stock solutions in 100% DMSO are unstable; reconstitute just prior to use.
References	Shu, S., et al. 2005. Proc. Natl. Acad. Sci. USA 102, 1472. Kovacs, M., et al. 2004. J. Biol. Chem. 279, 35557. Straight, A.F., et al. 2003. Science 299, 1743. Cheung, A., et al. 2001. Mol. Biol. Cell Suppl. 12, 271a.

种类

Life Science Research > Inhibitors and Biochemicals > Small Molecules & Inhibitors > ATPase/GTPase Inhibitors > ATPase Inhibitors

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