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			96-Well Plate

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	48-602MAG	Buffer Detection Kit for Magnetic Beads	1 Kit

196878 Sigma-Aldrich(±)-Bay K 8644 - CAS 93468-89-4 - Calbiochem

Synthetic dihydropyridine derivative that acts as an active Ca²⁺ slow channel agonist in neuroendocrine, muscle, thyroid and other cell types.

(±)-Bay K 8644 - CAS 93468-89-4 - Calbiochem MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.

MSDS
分析证书
参考
Data Sheet

同义词: 1,4-Dihydro-2,6-dimethyl-5-nitro-4-[2ʹ-(trifluoromethyl)phenyl]-3-pyridinecarboxylic Acid Methyl Ester

Primary Target: L-type Ca2+ channel

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Recommended Products

概述

Replacement Information

重要规格表

CAS #	Empirical Formula
93468-89-4	C₁₆H₁₅F₃N₂O₄

价格及供货情况

产品目录编号	库存情况	包装	数量 / 包装	价格	数量
196878-1MGCN	正在查询供货情况...... — 目前缺货有货停产少量现货供货情况有待确认登录查看库存有货目前缺货有货其余：另行通知其余：另行通知另行通知联系客户服务 Contact Customer Service 联系客户服务联系客户服务	塑胶安瓿;塑胶针药瓶	1 mg	正在检索价格...... 无法检索价格。最小订购数量为倍数 Maximum Quantity is 以订单确认为准更多信息您节约了 ()。 — Request Pricing 登录查看价格	查看库存情况 —	添加到收藏夹添加到收藏夹添加到我的收藏夹
196878-5MGCN	正在查询供货情况...... — 目前缺货有货停产少量现货供货情况有待确认登录查看库存有货目前缺货有货其余：另行通知其余：另行通知另行通知联系客户服务 Contact Customer Service 联系客户服务联系客户服务	塑胶安瓿;塑胶针药瓶	5 mg	正在检索价格...... 无法检索价格。最小订购数量为倍数 Maximum Quantity is 以订单确认为准更多信息您节约了 ()。 — Request Pricing 登录查看价格	查看库存情况 —	添加到收藏夹添加到收藏夹添加到我的收藏夹

Description
Overview	Synthetic dihydropyridine derivative that acts as an active Ca²⁺ slow channel agonist in neuroendocrine, muscle, thyroid and other cell types. Prolongs single channel open time without affecting the close time. An L-type Ca²⁺ channel agonist. Composed of two optical isomers. The (-)-enantiomer has strong vasoconstrictive, positive inotropic, and Ca²⁺ agonistic properties, whereas the (+)-enantiomer has weakly vasodilating, negative inotropic, and Ca²⁺ antagonistic properties. The net effect of the racemic mix is that of the negative enantiomer. Promotes β-cell proliferation/regeneration.
Catalogue Number	196878
Brand Family	Calbiochem®
Synonyms	1,4-Dihydro-2,6-dimethyl-5-nitro-4-[2ʹ-(trifluoromethyl)phenyl]-3-pyridinecarboxylic Acid Methyl Ester

References
References	Wang, W., et al. 2009. Proc. Natl. Acad. Sci. USA 106, 1427. Weigl, L.G., et al. 2000. J. Physiol. 525 (pt. 2), 461. Vannier, C., et al. 1995. Am. J. Physiol. 268, L201. Bechem, M., and Hoffmann, H. 1993. Pflugers Arch. 424, 343. Triggle, D.J., and Rompe, D. 1989. Trends Pharmacol. Sci. 10, 507. Takasu, N., et al. 1987. Biochem. Biophys. Res. Commun. 143, 1107. Tagliatela, M., et al. 1986. Brain Res. 381, 356. Franckowiak, G., et al. 1985. Eur. J. Pharmacol. 114, 223.

References

Wang, W., et al. 2009. Proc. Natl. Acad. Sci. USA 106, 1427.
Weigl, L.G., et al. 2000. J. Physiol. 525 (pt. 2), 461.
Vannier, C., et al. 1995. Am. J. Physiol. 268, L201.
Bechem, M., and Hoffmann, H. 1993. Pflugers Arch. 424, 343.
Triggle, D.J., and Rompe, D. 1989. Trends Pharmacol. Sci. 10, 507.
Takasu, N., et al. 1987. Biochem. Biophys. Res. Commun. 143, 1107.
Tagliatela, M., et al. 1986. Brain Res. 381, 356.
Franckowiak, G., et al. 1985. Eur. J. Pharmacol. 114, 223.

Product Information
CAS number	93468-89-4
ATP Competitive	N
Form	Yellow solid
Hill Formula	C₁₆H₁₅F₃N₂O₄
Chemical formula	C₁₆H₁₅F₃N₂O₄
Reversible	N
Structure formula Image
Quality Level	MQ100

Applications

Biological Information
Primary Target	L-type Ca2+ channel
Purity	≥98% by HPLC

Physicochemical Information
Cell permeable	N

Dimensions

Materials Information

Toxicological Information

Safety Information according to GHS

Safety Information
R Phrase	R: 36/38 Irritating to eyes and skin.
S Phrase	S: 26-36 In case of contact with eyes, rinse immediately with plenty of water and seek medical advice. Wear suitable protective clothing.

Product Usage Statements

Storage and Shipping Information
Ship Code	Ambient Temperature Only
Toxicity	Irritant
Storage	+2°C to +8°C
Protect from Light	Protect from light
Do not freeze	Ok to freeze
Special Instructions	Following reconstitution, store in the refrigerator (4°C). Stock solutions are stable for up to 20 days at 4°C.

Packaging Information

Transport Information

Supplemental Information

Specifications

Global Trade Item Number
产品目录编号	GTIN
196878-1MGCN	04055977206609
196878-5MGCN	04055977206616

Documentation

(±)-Bay K 8644 - CAS 93468-89-4 - Calbiochem MSDS

职位
物料安全数据表 (MSDS)

(±)-Bay K 8644 - CAS 93468-89-4 - Calbiochem 分析证书

标题	批号
196878	输入批号

参考

参考信息概述
Wang, W., et al. 2009. Proc. Natl. Acad. Sci. USA 106, 1427. Weigl, L.G., et al. 2000. J. Physiol. 525 (pt. 2), 461. Vannier, C., et al. 1995. Am. J. Physiol. 268, L201. Bechem, M., and Hoffmann, H. 1993. Pflugers Arch. 424, 343. Triggle, D.J., and Rompe, D. 1989. Trends Pharmacol. Sci. 10, 507. Takasu, N., et al. 1987. Biochem. Biophys. Res. Commun. 143, 1107. Tagliatela, M., et al. 1986. Brain Res. 381, 356. Franckowiak, G., et al. 1985. Eur. J. Pharmacol. 114, 223.

参考信息概述

数据表

Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

Revision	02-February-2009 JSW
Synonyms	1,4-Dihydro-2,6-dimethyl-5-nitro-4-[2ʹ-(trifluoromethyl)phenyl]-3-pyridinecarboxylic Acid Methyl Ester
Description	A synthetic dihydropyridine derivative that is an active Ca²⁺ slow channel agonist in neuroendocrine, muscle, thyroid, and other cell types. Prolongs single channel open time without affecting the close time. An L-type Ca²⁺ channel agonist. Composed of two optical isomers. The (-)-enantiomer has strong vasoconstrictive, positive ionotropic, and Ca²⁺ agonistic properties, whereas the (+)-enantiomer has weak vasodilating, negative ionotropic, and Ca²⁺ antagonistic properties. The net effect of the racemic mix is that of the negative enantiomer. Promotes β-cell proliferation/regeneration.
Form	Yellow solid
CAS number	93468-89-4
Chemical formula	C₁₆H₁₅F₃N₂O₄
Structure formula
Purity	≥98% by HPLC
Solubility	Ethanol (35 mg/ml) or DMSO (35 mg/ml)
Storage	Protect from light +2°C to +8°C
Do Not Freeze	Ok to freeze
Special Instructions	Following reconstitution, store in the refrigerator (4°C). Stock solutions are stable for up to 20 days at 4°C.
Toxicity	Irritant
References	Wang, W., et al. 2009. Proc. Natl. Acad. Sci. USA 106, 1427. Weigl, L.G., et al. 2000. J. Physiol. 525 (pt. 2), 461. Vannier, C., et al. 1995. Am. J. Physiol. 268, L201. Bechem, M., and Hoffmann, H. 1993. Pflugers Arch. 424, 343. Triggle, D.J., and Rompe, D. 1989. Trends Pharmacol. Sci. 10, 507. Takasu, N., et al. 1987. Biochem. Biophys. Res. Commun. 143, 1107. Tagliatela, M., et al. 1986. Brain Res. 381, 356. Franckowiak, G., et al. 1985. Eur. J. Pharmacol. 114, 223.

种类

Life Science Research > Inhibitors and Biochemicals > Small Molecules & Inhibitors > Neurochemicals > Channel Openers

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196878 Sigma-Aldrich(±)-Bay K 8644 - CAS 93468-89-4 - Calbiochem

Synthetic dihydropyridine derivative that acts as an active Ca²⁺ slow channel agonist in neuroendocrine, muscle, thyroid and other cell types.

同义词: 1,4-Dihydro-2,6-dimethyl-5-nitro-4-[2ʹ-(trifluoromethyl)phenyl]-3-pyridinecarboxylic Acid Methyl Ester

Recommended Products

概述

重要规格表

价格及供货情况

Documentation

(±)-Bay K 8644 - CAS 93468-89-4 - Calbiochem MSDS

(±)-Bay K 8644 - CAS 93468-89-4 - Calbiochem 分析证书

参考

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Synthetic dihydropyridine derivative that acts as an active Ca2+ slow channel agonist in neuroendocrine, muscle, thyroid and other cell types.

同义词: 1,4-Dihydro-2,6-dimethyl-5-nitro-4-[2ʹ-(trifluoromethyl)phenyl]-3-pyridinecarboxylic Acid Methyl Ester

Recommended Products

重要规格表

价格及供货情况

(±)-Bay K 8644 - CAS 93468-89-4 - Calbiochem MSDS

(±)-Bay K 8644 - CAS 93468-89-4 - Calbiochem 分析证书

参考

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Synthetic dihydropyridine derivative that acts as an active Ca²⁺ slow channel agonist in neuroendocrine, muscle, thyroid and other cell types.