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565740 Sigma-Aldrichα-Amyloid Precursor Protein Modulator - CAS 497259-23-1 - Calbiochem

A cell-permeable benzolactam derived PKC activator (K_i = 11.9 nM for PKCα) that efficiently enhances non-amyloidogenic α-processing of amyloid precursor protein (APP) even at 100 nM in human fibroblast AG06848.

MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.

MSDS
分析证书
参考
Data Sheet

同义词: (2S,5S)-(E,E)-8-(5-(4-(Trifluoromethyl)phenyl)-2,4-pentadienoylamino)benzolactam, PKC Activator V

Primary Target: PKC

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概述

Replacement Information

重要规格表

CAS #	Empirical Formula
497259-23-1	C₂₇H₃₀F₃N₃O₃

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Description
Overview	A cell-permeable benzolactam derived PKC activator (K_i = 11.9 nM for PKCα) that efficiently enhances non-amyloidogenic α-processing of amyloid precursor protein (APP) even at 100 nM in human fibroblast AG06848. Displays a marked loss of tumor promoting activity.
Catalogue Number	565740
Brand Family	Calbiochem®
Synonyms	(2S,5S)-(E,E)-8-(5-(4-(Trifluoromethyl)phenyl)-2,4-pentadienoylamino)benzolactam, PKC Activator V

References
References	Kozikowski, A.P., et al. 2003. J. Med. Chem. 46, 364.

Product Information
CAS number	497259-23-1
ATP Competitive	N
Form	Orange solid
Hill Formula	C₂₇H₃₀F₃N₃O₃
Chemical formula	C₂₇H₃₀F₃N₃O₃
Reversible	N
Structure formula Image
Quality Level	MQ100

Applications

Biological Information
Primary Target	PKC
Primary Target K<sub>i</sub>	11.9 nM for activating PKCα
Purity	≥95% by HPLC

Physicochemical Information
Cell permeable	Y

Dimensions

Materials Information

Toxicological Information

Safety Information according to GHS

Safety Information

Product Usage Statements

Storage and Shipping Information
Ship Code	Blue Ice Only
Toxicity	Standard Handling
Storage	-20°C
Protect from Light	Protect from light
Do not freeze	Ok to freeze
Special Instructions	Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.

Packaging Information
Packaged under inert gas	Packaged under inert gas

Transport Information

Supplemental Information

Specifications

Global Trade Item Number
产品目录编号	GTIN
565740-1MGCN	04055977267648

Documentation

α-Amyloid Precursor Protein Modulator - CAS 497259-23-1 - Calbiochem MSDS

职位
物料安全数据表 (MSDS)

α-Amyloid Precursor Protein Modulator - CAS 497259-23-1 - Calbiochem 分析证书

标题	批号
565740	输入批号

参考

参考信息概述
Kozikowski, A.P., et al. 2003. J. Med. Chem. 46, 364.

数据表

Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

Revision	17-September-2010 JSW
Synonyms	(2S,5S)-(E,E)-8-(5-(4-(Trifluoromethyl)phenyl)-2,4-pentadienoylamino)benzolactam, PKC Activator V
Description	A cell-permeable PKC activator (K_i = 11.9 nM for PKCα) that efficiently enhances non-amyloidogenic α-processing of amyloid precursor protein (APP) but lacks any tumor promoting activity.
Form	Orange solid
Intert gas (Yes/No)	Packaged under inert gas
CAS number	497259-23-1
Chemical formula	C₂₇H₃₀F₃N₃O₃
Structure formula
Purity	≥95% by HPLC
Solubility	DMSO (50 mg/ml) or Methanol (1 mg/ml)
Storage	Protect from light -20°C
Do Not Freeze	Ok to freeze
Special Instructions	Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.
Toxicity	Standard Handling
References	Kozikowski, A.P., et al. 2003. J. Med. Chem. 46, 364.

种类

Life Science Research > Inhibitors and Biochemicals > Small Molecules & Inhibitors > Activators > Kinases Activators > Protein Kinase C Activators

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565740 Sigma-Aldrichα-Amyloid Precursor Protein Modulator - CAS 497259-23-1 - Calbiochem

A cell-permeable benzolactam derived PKC activator (K_i = 11.9 nM for PKCα) that efficiently enhances non-amyloidogenic α-processing of amyloid precursor protein (APP) even at 100 nM in human fibroblast AG06848.

同义词: (2S,5S)-(E,E)-8-(5-(4-(Trifluoromethyl)phenyl)-2,4-pentadienoylamino)benzolactam, PKC Activator V

Recommended Products

概述

重要规格表

价格及供货情况

Documentation

α-Amyloid Precursor Protein Modulator - CAS 497259-23-1 - Calbiochem MSDS

α-Amyloid Precursor Protein Modulator - CAS 497259-23-1 - Calbiochem 分析证书

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A cell-permeable benzolactam derived PKC activator (Ki = 11.9 nM for PKCα) that efficiently enhances non-amyloidogenic α-processing of amyloid precursor protein (APP) even at 100 nM in human fibroblast AG06848.

同义词: (2S,5S)-(E,E)-8-(5-(4-(Trifluoromethyl)phenyl)-2,4-pentadienoylamino)benzolactam, PKC Activator V

Recommended Products

重要规格表

价格及供货情况

α-Amyloid Precursor Protein Modulator - CAS 497259-23-1 - Calbiochem MSDS

α-Amyloid Precursor Protein Modulator - CAS 497259-23-1 - Calbiochem 分析证书

参考

种类

最近查看的内容

A cell-permeable benzolactam derived PKC activator (K_i = 11.9 nM for PKCα) that efficiently enhances non-amyloidogenic α-processing of amyloid precursor protein (APP) even at 100 nM in human fibroblast AG06848.