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A cell permeable, fluorene compound that destabilizes the aggregation state of β-amyloid oligomers (AβO) by directly targeting AβO and inhibiting AβO binding to synapses. It displays full MC65 protection at 125 nM, with an EC50 of 80 nM in a neuronal MC65 culture-based assay, and substantially reduces intraneuronal AβO in primary neuronal culture at concentrations between 100 nM and 10 µM. Furthermore, it is shown to significantly reduce amyloid levels by 50% compared with control in vivo in a 5xFAD mice cerebral Aβ amyloidosis model when dosed intracerebroventricularly without apparent toxicity.
Catalogue Number
200487
Brand Family
Calbiochem®
Synonyms
AβO Inhibitor, K01-162
References
References
Hong, H-S., et al. 2010. Neurobiol. Aging31, 1690.
Hong, H-S., et al. 2010. Neurobiol. Aging31, 1690.
数据表
Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.
Revision
23-March-2018 JSW
Synonyms
AβO Inhibitor, K01-162
Description
A cell permeable, fluorene compound that destabilizes the aggregation state of β-amyloid oligomers (AβO) by directly targeting AβO and inhibiting AβO binding to synapses. It displays full MC65 protection at 125 nM, with an EC50 of 80 nM in a neuronal MC65 culture-based assay, and substantially reduces intraneuronal AβO in primary neuronal culture at concentrations between 100 nM and 10 µM. Furthermore, it is shown to significantly reduce amyloid levels by 50% compared with control in vivo in a 5xFAD mice cerebral Aβ amyloidosis model when dosed intracerebroventricularly without apparent toxicity.
Form
White to off-white solid
Intert gas (Yes/No)
Packaged under inert gas
Chemical formula
C₁₅H₁₄BrN
Structure formula
Purity
≥95% by HPLC
Solubility
DMSO (50 mg/ml)
Storage
Protect from light
Avoid freeze/thaw
+2°C to +8°C
Do Not Freeze
Ok to freeze
Special Instructions
Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
Toxicity
Standard Handling
References
Hong, H-S., et al. 2010. Neurobiol. Aging31, 1690.
