An efficient way to increase capacity, recovery and concentration

Merck is pleased to introduce Single-Pass TFF with Pellicon® cassettes, an enhanced application of our existing TFF technology that allows you to concentrate process streams without the recirculation required in traditional TFF steps. This alternative application eliminates typical process constraints caused by higher volumes or concentration factors, resulting in increased capacity. It also enables continuous processing by coupling the TFF step in-line with other process steps.

With increased upstream (e.g., bioreactor) productivity, process volumes have expanded requiring drug manufacturers to invest in larger tanks and chromatography columns. Running Pellicon® cassettes in single-pass mode is a simple and effective way to reduce process volumes through concentration, and reduce tank volumes and chromatography column sizes.

Higher concentration final formulations (e.g., injectable therapies) make recovery from traditional batch TFF systems challenging. Single-pass TFF has a lower hold-up volume that allows both higher concentration factors and easier product recovery.

Single-pass TFF can also create more compact and efficient processes. For example, it can be directly coupled with a chromatography step for in-line feed conditioning or desalting.

Using the proven technology of Pellicon® cassettes, single-pass TFF can address processing constraints, increase capacity and streamline downstream processes.

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In This Same Issue:

• Updated Sterile Filtration Product Selection Guide now available
• Merck announces winner of 2014 Emerging Biotech Grant Program
• New! Formulation Product Finder App