Conquer high concentration challenges: new Pellicon™ 3 cassettes with D screen

The need to process high concentration liquid formulations is driven by the desire to create injectable therapies. Traditionally many of these therapies were administered by infusion. For patients, injection means ease of administration and convenience. For the manufacturer, injection provides product lost common to reconstituting powders in order to fill syringes.

The current Ultrafiltration (UF) processes used to produce liquid formulations can be constrained at high concentrations due to pressure limitations.

To address these challenges, we've developed a new D screen for our Pellicon™ 3 cassettes with 30 kD Ultracel® membrane. Optimized for processing high concentration liquid formulations, this new screen creates gentle turbulence at the membrane surface to control the effects of concentration polarization. In addition, it creates hydraulic resistance, resulting in a higher pressure drop within operating specifications.

From small-scale to full-scale production, Pellicon™ 3 cassettes with Ultracel® membrane are the device of choice for applications with high fouling process streams such as lipids, DNA and RNA. The streamlined design allows operators to quickly and easily handle, install and remove Pellicon™ 3 cassettes. And, the materials of construction are compatible with a broad range of chemical cleaning agents that many TFF systems require to ensure proper sanitization.

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