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203695 bpV(phen) - CAS 42494-73-5 - Calbiochem

Overview

Key Spec Table

CAS #Empirical Formula
42494-73-5K[VO(O₂)₂C₁₂H₈N₂]

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203695-10MGCN
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      Description
      OverviewA potent protein phosphotyrosine phosphatase inhibitor and insulin receptor kinase (IRK) activator. Excellent insulin mimetic at 15 µg/kg in vitro and in vivo for use. Inhibits the in situ dephosphorylation of autophosphorylated insulin receptors with over 1000-fold greater potency than sodium orthovanadate. Arrests proliferation of neuroblastoma NB 41 and glioma C6 cells at the G2/M transition of the cell cycle. Also reported to potently inhibit PTEN (IC50 = 38 nM).
      The water content varies from lot to lot and is supplied on the label along with the lot-specific molecular weight.
      Catalogue Number203695
      Brand Family Calbiochem®
      SynonymsPotassium Bisperoxo(1,10-phenanthroline)oxovanadate (V), PTEN Inhibitor I, PTP Inhibitor VIII
      References
      ReferencesSchmid, A.C., et al. 2004. FEBS Lett. 566, 35.
      Muzyamba, M.C., et al. 1999. J. Physiol. 517, 421.
      Drake, P.G., et al. 1996. Endocrinology 137, 4960.
      Bevan, A.P., et al. 1995. Am. J. Physiol. 268, E60.
      Bevan, A.P., et al. 1995. J. Biol. Chem. 270, 10784.
      Yale, J.F., et al. 1995. Diabetes 44, 1274.
      Posner, B.I., et al. 1994. J. Biol. Chem. 269, 4596.
      Product Information
      CAS number42494-73-5
      ATP CompetitiveN
      FormYellow solid
      Hill FormulaK[VO(O₂)₂C₁₂H₈N₂]
      Chemical formulaK[VO(O₂)₂C₁₂H₈N₂]
      ReversibleN
      Structure formula ImageStructure formula Image
      Quality LevelMQ100
      Applications
      ApplicationbpV(phen, CAS 42494-73-5, is an insulin mimetic and an inhibitor of protein phosphotyrosine phosphatase. More potent in dephosphorylating of autophosphorylated insulin receptor than orthovanadate.
      Biological Information
      Primary TargetPTEN
      Primary Target IC<sub>50</sub>38 nM
      Purity≥99% by ⁵¹V-NMR
      Physicochemical Information
      Cell permeableN
      Storage and Shipping Information
      Ship Code Ambient Temperature Only
      Toxicity Standard Handling
      Storage -20°C
      Protect from Light Protect from light
      Do not freeze Ok to freeze
      Special InstructionsUnstable in solution; reconstitute just prior to use.
      Packaging Information
      Packaged under inert gas Packaged under inert gas
      Global Trade Item Number
      Catalogue Number GTIN
      203695-10MGCN 07790788048365