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691550 Zinc (II) Protoporphyrin IX - CAS 15442-64-5 - Calbiochem

A potent and selective inhibitor of heme oxygenase, the enzyme which generates carbon monoxide (CO) and biliverdin.

MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.

Synonyms: ZnPP-9

Primary Target: heme oxygenase
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691550
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Overview

Replacement Information

Key Spec Table

CAS #Empirical Formula
15442-64-5C₃₄H₃₂N₄O₄Zn

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691550-25MGCN
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      Description
      OverviewA potent and selective inhibitor of heme oxygenase, the enzyme which generates carbon monoxide (CO) and biliverdin. Inhibits soluble guanylyl cyclase and produces a time- and concentration-dependent inactivation of all three isoforms of nitric oxide synthase (IC50 = 800 nM, 4 µM, and 5 µM for nNOS, iNOS, and eNOS, respectively). Inhibits relaxation induced by acetylcholine, ANP, and VIP in isolated rat aorta. Blocks interleukin-1 and prevents induction of long-term potentiation. Also useful as an indicator of iron-deficient erythropoiesis. Does not cross the blood-brain barrier.
      Catalogue Number691550
      Brand Family Calbiochem®
      SynonymsZnPP-9
      References
      ReferencesWolff, D.J., et al. 1996. Arch. Biochem. Biophys. 333, 27.
      Bing, O., et al. 1995. NeuroReport 6, 1369.
      Hinchliffe, R.F., et al. 1995. Pediatr. Hematol. Oncol. 12, 455.
      Kadoya, C., et al. 1995. Stroke 26, 1035.
      Ny, L., et al. 1995. Br. J. Pharmacol. 115, 186.
      Luo, D., and Vincent, S.R. 1994. Eur. J. Pharmacol. 267, 263.
      Marks, G.S., et al. 1993. Can. J. Physiol. Pharmacol. 71, 753.
      Zhuo, M., et al. 1993. Science 260, 1946.
      Product Information
      CAS number15442-64-5
      ATP CompetitiveN
      FormDark red solid
      Hill FormulaC₃₄H₃₂N₄O₄Zn
      Chemical formulaC₃₄H₃₂N₄O₄Zn
      ReversibleN
      Structure formula ImageStructure formula Image
      Quality LevelMQ100
      Applications
      Biological Information
      Primary Targetheme oxygenase
      Primary Target IC<sub>50</sub> 800 nM, 4 µM, and 5 µM for nNOS, iNOS, and eNOS, respectively
      Purity≥95% by TLC
      Physicochemical Information
      Cell permeableN
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      Product Usage Statements
      Storage and Shipping Information
      Ship Code Ambient Temperature Only
      Toxicity Standard Handling
      Storage -20°C
      Protect from Light Protect from light
      Do not freeze Ok to freeze
      Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C).
      Packaging Information
      Transport Information
      Supplemental Information
      Specifications
      Global Trade Item Number
      Catalogue Number GTIN
      691550-25MGCN 04055977225143

      Documentation

      Zinc (II) Protoporphyrin IX - CAS 15442-64-5 - Calbiochem SDS

      Title

      Safety Data Sheet (SDS) 

      Zinc (II) Protoporphyrin IX - CAS 15442-64-5 - Calbiochem Certificates of Analysis

      TitleLot Number
      691550

      References

      Reference overview
      Wolff, D.J., et al. 1996. Arch. Biochem. Biophys. 333, 27.
      Bing, O., et al. 1995. NeuroReport 6, 1369.
      Hinchliffe, R.F., et al. 1995. Pediatr. Hematol. Oncol. 12, 455.
      Kadoya, C., et al. 1995. Stroke 26, 1035.
      Ny, L., et al. 1995. Br. J. Pharmacol. 115, 186.
      Luo, D., and Vincent, S.R. 1994. Eur. J. Pharmacol. 267, 263.
      Marks, G.S., et al. 1993. Can. J. Physiol. Pharmacol. 71, 753.
      Zhuo, M., et al. 1993. Science 260, 1946.
      Data Sheet

      Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

      Revision16-September-2008 RFH
      SynonymsZnPP-9
      DescriptionA potent and selective inhibitor of heme oxygenase, the enzyme which generates carbon monoxide (CO) and biliverdin. Inhibits soluble guanylyl cyclase. Produces a time- and concentration-dependent inactivation of all three isoforms of nitric oxide synthase (IC50 = 0.8 µM, 4.0 µM, and 5.0 µM for nNOS, iNOS, and eNOS, respectively). Inhibits relaxation induced by acetylcholine, ANP, and VIP in isolated rat aorta. Blocks interleukin-1 and prevents induction of long-term potentiation. Also useful as an indicator of iron deficient erythropoiesis. Does not cross the blood-brain barrier.
      FormDark red solid
      CAS number15442-64-5
      Chemical formulaC₃₄H₃₂N₄O₄Zn
      Structure formulaStructure formula
      Purity≥95% by TLC
      SolubilityDMF or Pyridine
      Storage Protect from light
      -20°C
      Do Not Freeze Ok to freeze
      Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C).
      Toxicity Standard Handling
      ReferencesWolff, D.J., et al. 1996. Arch. Biochem. Biophys. 333, 27.
      Bing, O., et al. 1995. NeuroReport 6, 1369.
      Hinchliffe, R.F., et al. 1995. Pediatr. Hematol. Oncol. 12, 455.
      Kadoya, C., et al. 1995. Stroke 26, 1035.
      Ny, L., et al. 1995. Br. J. Pharmacol. 115, 186.
      Luo, D., and Vincent, S.R. 1994. Eur. J. Pharmacol. 267, 263.
      Marks, G.S., et al. 1993. Can. J. Physiol. Pharmacol. 71, 753.
      Zhuo, M., et al. 1993. Science 260, 1946.