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14-594M VHR Protein, 250 µg

N-terminal GST-tagged, recombinant VHR expressed in E. coli, for use in Phosphatase Assays.

14-594M
250 µg  Also available in 10 μg size (cat#14-594) and in bulk (cat# 14-594-K).
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      Overview

      Replacement Information
      Description
      Catalogue Number14-594M
      Brand Family Upstate
      Trade Name
      • Upstate
      DescriptionVHR Protein, 250 µg
      OverviewN-terminal GST-tagged, recombinant VHR expressed in E. coli
      References
      Product Information
      Quality LevelMQ300
      Applications
      ApplicationN-terminal GST-tagged, recombinant VHR expressed in E. coli, for use in Phosphatase Assays.
      Key Applications
      • Phosphatase Assay
      Biological Information
      Sourcerecombinant human full-length VHR expressed in E. coli
      Specific ActivityFor Specific Activity data, refer to the Certificate of Analysis for individual lots of this enzyme.
      Entrez Gene Number
      Entrez Gene SummaryThe protein encoded by this gene is a member of the dual specificity protein phosphatase subfamily. These phosphatases inactivate their target kinases by dephosphorylating both the phosphoserine/threonine and phosphotyrosine residues. They negatively regulate members of the mitogen-activated protein (MAP) kinase superfamily (MAPK/ERK, SAPK/JNK, p38), which are associated with cellular proliferation and differentiation. Different members of the family of dual specificity phosphatases show distinct substrate specificities for various MAP kinases, different tissue distribution and subcellular localization, and different modes of inducibility of their expression by extracellular stimuli. This gene maps in a region that contains the BRCA1 locus which confers susceptibility to breast and ovarian cancer. Although DUSP3 is expressed in both breast and ovarian tissues, mutation screening in breast cancer pedigrees and in sporadic tumors was negative, leading to the conclusion that this gene is not BRCA1.
      Gene Symbol
      • DUSP3
      • VHR
      Protein TargetVHR
      Purification MethodGlutathione-agarose
      Target Sub-FamilySer/Thr/Tyr phosphatase
      UniProt Number
      UniProt SummaryFUNCTION: SwissProt: P51452 # This protein shows activity both toward tyrosine-protein phosphate as well as with serine-protein phosphate.
      SIZE: 185 amino acids; 20478 Da
      SIMILARITY: SwissProt: P51452 ## Belongs to the protein-tyrosine phosphatase family. Non-receptor class dual specificity subfamily. & Contains 1 tyrosine-protein phosphatase domain.
      Molecular Weight47.8kDa
      Physicochemical Information
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      Product Usage Statements
      Quality Assuranceroutinely evaluated by phosphorylation of DiFMUP
      Usage Statement
      • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
      Storage and Shipping Information
      Storage Conditions6 months at -70°C
      Packaging Information
      Material Size250 µg
      Material PackageAlso available in 10 μg size (cat#14-594) and in bulk (cat# 14-594-K).
      Transport Information
      Supplemental Information
      Specifications
      Global Trade Item Number
      Catalogue Number GTIN
      14-594M 04053252510892

      Documentation

      Related Products & Applications

      Alternative Packsize

      Catalogue Number Description  
      14-594 VHR Protein, 10 µg Show Pricing & Availability

      Product Families

      Kinase & Phosphatase Products

      Millipore offers a large portfolio of Kinases, Phophatases, Substrates, Inhibitors, Kits, reagents & tools for Signaling research. See below for a list of these products, in multiple pack sizes.
      Learn More >>

      Categories

      Life Science Research > Drug Discovery and Development > Kinase & Phosphatase Screening > Purified Phosphatases
      Life Science Research > Proteins and Enzymes > Purified Phosphatases