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616453 TGF-β RI Kinase Inhibitor III - CAS 356559-13-2 - Calbiochem

The TGF-β RI Kinase Inhibitor III, also referenced under CAS 356559-13-2, controls the biological activity of TGF-β RI Kinase. This small molecule/inhibitor is primarily used for Phosphorylation &

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Synonyms: Transforming Growth Factor-β Type I Receptor Kinase Inhibitor III, 2-(5-Benzo[1,3]dioxol-4-yl-2-tert-butyl-1H-imidazol-4-yl)-6-methylpyridine, HCl, ALK5 Inhibitor III, SB-505124, HCl

Primary Target: Activin receptor-like kinase 4, 5, 7
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616453
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Overview

Key Spec Table

CAS #Empirical Formula
356559-13-2C₂₀H₂₁N₃O₂ • HCl

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      Description
      OverviewA cell-permeable imidazolyl-pyridine compound that acts as a potent, ATP-competitive, reversible, and selective inhibitor of activin receptor-like kinase 4 (IC50 = 129 nM), 5 ( IC50 = 47 nM), and 7. It inhibits p38 MAPKα only at much higher concentrations (IC50 = 10.6 µM) and has little effect against ALK1/2/3/6 as well as a panel of 26 other kinases.
      Catalogue Number616453
      Brand Family Calbiochem®
      SynonymsTransforming Growth Factor-β Type I Receptor Kinase Inhibitor III, 2-(5-Benzo[1,3]dioxol-4-yl-2-tert-butyl-1H-imidazol-4-yl)-6-methylpyridine, HCl, ALK5 Inhibitor III, SB-505124, HCl
      References
      ReferencesHu, T., et al. 2005. Am. J. Physiol. Renal Physiol. 289, F816.
      DaCosta Byfield, S., et al. 2004. Mol. Pharmacol. 65, 744.
      Product Information
      CAS number356559-13-2
      ATP CompetitiveY
      FormLight yellow solid
      Hill FormulaC₂₀H₂₁N₃O₂ • HCl
      Chemical formulaC₂₀H₂₁N₃O₂ • HCl
      Hygroscopic Hygroscopic
      ReversibleY
      Structure formula ImageStructure formula Image
      Quality LevelMQ100
      Biological Information
      Primary TargetActivin receptor-like kinase 4, 5, 7
      Primary Target IC<sub>50</sub>129 nM, 47 nM, against activin receptor-like kinase 4, 5, respectively
      Purity≥97% by HPLC
      Physicochemical Information
      Cell permeableY
      Storage and Shipping Information
      Ship Code Ambient Temperature Only
      Toxicity Irritant
      Storage +2°C to +8°C
      Protect from Light Protect from light
      Hygroscopic Hygroscopic
      Do not freeze Ok to freeze
      Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.
      Packaging Information
      Packaged under inert gas Packaged under inert gas
      Global Trade Item Number
      Catalogue Number GTIN
      616453-2MGCN 04055977185843