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573108 STAT5 Inhibitor - CAS 285986-31-4 - Calbiochem

STAT5 Inhibitor, CAS 285986-31-4, is a cell-permeable compound that selectively targets the SH2 domain of STAT5 (IC50 = 47 µM against STAT5b SH2 domain EPO peptide binding activity).

MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.

Synonyms: Nʹ-((4-Oxo-4H-chromen-3-yl)methylene)nicotinohydrazide

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573108
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Overview

Replacement Information

Key Spec Table

CAS #Empirical Formula
285986-31-4C₁₆H₁₁N₃O₃

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      Description
      OverviewA cell-permeable nonpeptidic nicotinoyl hydrazone compound that selectively targets the SH2 domain of STAT5 (IC50 = 47 µM against STAT5b SH2 domain EPO peptide binding activity), while exhibiting much less effect towards the SH2 domain of STAT1, STAT3, or Lck (IC50 >500 µM). Shown to block STAT5/STAT5 DNA binding activity in K562 nuclear extract and inhibit IFN-α-stimulated STAT5, but not STAT1 or STAT3, tyrosine phosphorylation in Daudi cells.
      Catalogue Number573108
      Brand Family Calbiochem®
      SynonymsNʹ-((4-Oxo-4H-chromen-3-yl)methylene)nicotinohydrazide
      References
      ReferencesMuller, J., et al. 2008. ChemBioChem 9, 723.
      Product Information
      CAS number285986-31-4
      FormWhite solid
      Hill FormulaC₁₆H₁₁N₃O₃
      Chemical formulaC₁₆H₁₁N₃O₃
      Structure formula ImageStructure formula Image
      Quality LevelMQ100
      Applications
      ApplicationSTAT5 Inhibitor, CAS 285986-31-4, is a cell-permeable compound that selectively targets the SH2 domain of STAT5 (IC50 = 47 µM against STAT5b SH2 domain EPO peptide binding activity).
      Biological Information
      Purity≥97% by HPLC
      Physicochemical Information
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      Product Usage Statements
      Storage and Shipping Information
      Ship Code Ambient Temperature Only
      Toxicity Standard Handling
      Storage +2°C to +8°C
      Protect from Light Protect from light
      Do not freeze Ok to freeze
      Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
      Packaging Information
      Packaged under inert gas Packaged under inert gas
      Transport Information
      Supplemental Information
      Specifications
      Global Trade Item Number
      Catalogue Number GTIN
      573108-10MGCN 04055977265941

      Documentation

      STAT5 Inhibitor - CAS 285986-31-4 - Calbiochem Certificates of Analysis

      TitleLot Number
      573108

      References

      Reference overview
      Muller, J., et al. 2008. ChemBioChem 9, 723.

      Brochure

      Title
      An Introduction to Inhibitors and Their Biological Applications - 1st Edition

      Technical Info

      Title
      JAK/STAT Signaling Research Focus
      Data Sheet

      Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

      Revision09-May-2011 RFH
      SynonymsNʹ-((4-Oxo-4H-chromen-3-yl)methylene)nicotinohydrazide
      DescriptionA cell-permeable nonpeptidic nicotinoyl hydrazone compound that selectively targets the SH2 domain of STAT5 (IC50 = 47 µM against STAT5b SH2 domain EPO peptide binding activity), while exhibiting much less effect towards the SH2 domain of STAT1, STAT3, or Lck (IC50 >500 µM). Shown to block STAT5/STAT5 DNA binding activity in K562 nuclear extract and inhibit IFN-α-stimulated STAT5, but not STAT1 or STAT3, tyrosine phosphorylation in Daudi cells.
      FormWhite solid
      Intert gas (Yes/No) Packaged under inert gas
      CAS number285986-31-4
      Chemical formulaC₁₆H₁₁N₃O₃
      Structure formulaStructure formula
      Purity≥97% by HPLC
      SolubilityDMSO (25 mg/ml)
      Storage Protect from light
      +2°C to +8°C
      Do Not Freeze Ok to freeze
      Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
      Toxicity Standard Handling
      ReferencesMuller, J., et al. 2008. ChemBioChem 9, 723.