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531371 S1P Receptor 2 Agonist, CYM-5520 - CAS 1449747-00-5 - Calbiochem

Overview

Key Spec Table

CAS #Empirical Formula
1449747-00-5C₂₁H₁₉N₃O₂

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5.31371.0001
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      Glass bottle 10 mg
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      Description
      OverviewA pyrrolyl ketone derivative that acts as a potent, selective, allosteric agonist of sphingosine-1-phosphate receptor 2 (S1PR2; EC50 = 480 nM) that does not replace native ligand and its binding is not competitive with JTE-013. Does not affect the activity of S1PR1, 3, and 5 and the activity of 29 other receptors and transports in any significant manner. Acts as a full agonist for both wild type and triple mutant S1PR2 (EC50 = 1.6 and 1.5 µM, respectively).

      Please note that the molecular weight for this compound is batch-specific due to variable water content.
      Catalogue Number531371
      Brand Family Calbiochem®
      SynonymsS1PR2 Agonist, CYM-5520, Sphingosine-1-Phosphate Receptor 2 Agonist, CYM 5520, EDG5 Agonist
      References
      ReferencesSatsu, H., et al. 2013. Bioorg. Med. Chem. 21, 5373.
      Product Information
      CAS number1449747-00-5
      FormOff-white solid
      Hill FormulaC₂₁H₁₉N₃O₂
      Chemical formulaC₂₁H₁₉N₃O₂
      ReversibleY
      Quality LevelMQ100
      Biological Information
      Primary TargetS1PR2
      Purity≥98% by HPLC
      Storage and Shipping Information
      Ship Code Shipped at Ambient Temperature or with Blue Ice or with Dry Ice
      Toxicity Standard Handling
      Storage +2°C to +8°C
      Protect from Light Protect from light
      Do not freeze Ok to freeze
      Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C).
      Packaging Information
      Packaged under inert gas Packaged under inert gas
      Global Trade Item Number
      Catalogue Number GTIN
      5.31371.0001 04055977260298