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553210 Rapamycin - CAS 53123-88-9 - Calbiochem

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Rapamycin - CAS 53123-88-9 - Calbiochem MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.

Synonyms: mTOR Inhibitor I

Primary Target: Mammalian target of rapamycin (mTOR)
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553210
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Overview

Replacement Information

Key Spec Table

CAS #Empirical Formula
53123-88-9C₅₁H₇₉NO₁₃

Pricing & Availability

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553210-1MGCN
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      		 Plastic ampoule 1 mg
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      553210-5MGCN
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          		 Glass bottle 5 mg
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          Description
          OverviewAnti-fungal and immunosuppressant. Selectively inhibits the mammalian target of rapamycin (mTOR) and blocks the subsequent activation of p70 S6 kinase (IC50 = 50 pM). Specifically inhibits mTORC1, but mTORC2 that phosphorylates Akt at Ser473 appears to be insensitive to rapamycin. Prevents the translational activation of IGF-II. Also prevents resting T-cells from entering the cell cycle, but does not directly arrest cell cycle progression. Shown to inhibit later signaling events, such as p110Rb phosphorylation, p34cdc2 kinase activation, and cyclin A synthesis. Exhibits strong binding to FK-506 binding proteins. Also reported to induce apoptosis in a murine B-cell line, to inhibit lymphokine-induced cell proliferation at the G1 phase, and to irreversibly arrest Saccharomyces cerevisiae cells in the G1 phase. A 5 mM (500 µg/109 µl) solution of Rapamycin (Cat. No. 553211) in DMSO and a 10 mM (1 mg/109 µl) solution of Rapamycin (Cat. No. 553212) in EtOH is also available.
          Catalogue Number553210
          Brand Family Calbiochem®
          SynonymsmTOR Inhibitor I
          References
          ReferencesChen, T., et al. 2011. Aging Cell. 10, 908.
          Powell, D.J., et al. 2003. Mol. cell Biol. 23, 7794.
          Braun, W., et al. 1995. FASEB J. 9, 63.
          Nielsen, F.C., et al. 1995. Nature 377, 358.
          Aagaard-Tillery, K.M. and Jelinek, D.F. 1994. Cell. Immunol. 156, 493.
          Gottschalk, A.R., et al. 1994. Proc. Natl. Acad. Sci. USA 91, 7350.
          Morice, W.G., et al. 1993. J. Biol. Chem. 268, 3734.
          Terada, N., et al. 1993. J. Biol. Chem. 268, 12062.
          Kuo, J., et al. 1992. Nature 358, 70.
          Price, D.J., et al. 1992. Science 257, 973.
          Heitman, J., et al. 1991. Science 253, 905.
          Kay, J.E., et al. 1991. Immunology 72, 544.
          Schreiber, S.L. 1991. Science 251, 283.
          Bierer, B.E., et al. 1990. Proc. Natl. Acad. Sci. USA 87, 9231.
          Dumont, F.J., et al. 1990. J. Immunol. 144, 251.
          Product Information
          CAS number53123-88-9
          ATP CompetitiveN
          FormClear film
          Hill FormulaC₅₁H₇₉NO₁₃
          Chemical formulaC₅₁H₇₉NO₁₃
          ReversibleN
          Structure formula ImageStructure formula Image
          Quality LevelMQ200
          Applications
          Biological Information
          Primary TargetMammalian target of rapamycin (mTOR)
          Primary Target IC<sub>50</sub>50 pM against p70 S6 kinase
          Purity≥99% by HPLC
          Physicochemical Information
          Cell permeableN
          Dimensions
          Materials Information
          Toxicological Information
          Safety Information according to GHS
          RTECSVE6250000
          Safety Information
          Product Usage Statements
          Storage and Shipping Information
          Ship Code Ambient Temperature Only
          Toxicity Standard Handling
          Storage -20°C
          Do not freeze Ok to freeze
          Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
          Packaging Information
          Transport Information
          Supplemental Information
          Specifications
          Global Trade Item Number
          Catalogue Number GTIN
          553210-1MGCN 04055977193480
          553210-5MGCN 04055977193534

          Documentation

          Rapamycin - CAS 53123-88-9 - Calbiochem SDS

          Title

          Safety Data Sheet (SDS) 

          Rapamycin - CAS 53123-88-9 - Calbiochem Certificates of Analysis

          TitleLot Number
          553210

          References

          Reference overview
          Chen, T., et al. 2011. Aging Cell. 10, 908.
          Powell, D.J., et al. 2003. Mol. cell Biol. 23, 7794.
          Braun, W., et al. 1995. FASEB J. 9, 63.
          Nielsen, F.C., et al. 1995. Nature 377, 358.
          Aagaard-Tillery, K.M. and Jelinek, D.F. 1994. Cell. Immunol. 156, 493.
          Gottschalk, A.R., et al. 1994. Proc. Natl. Acad. Sci. USA 91, 7350.
          Morice, W.G., et al. 1993. J. Biol. Chem. 268, 3734.
          Terada, N., et al. 1993. J. Biol. Chem. 268, 12062.
          Kuo, J., et al. 1992. Nature 358, 70.
          Price, D.J., et al. 1992. Science 257, 973.
          Heitman, J., et al. 1991. Science 253, 905.
          Kay, J.E., et al. 1991. Immunology 72, 544.
          Schreiber, S.L. 1991. Science 251, 283.
          Bierer, B.E., et al. 1990. Proc. Natl. Acad. Sci. USA 87, 9231.
          Dumont, F.J., et al. 1990. J. Immunol. 144, 251.

          Brochure

          Title
          Bulk Product Guide
          Caspases and other Apoptosis Related Tools Brochure

          Data Sheet

          Title
          Reprogramming Cell Fate and Function Novel Strategies for iPSC Generation, Characterization, and Differentiation

          Posters

          Title
          Human Kinome & InhibitorSelect™ Libraries

          Citations

          Title
        • Chen, T., et al. 2011. Aging Cell. 10, 908.
        • Yu, YL., et al. 2005. Journal of Biological Chemistry 280, 29533.
        • Vega, R.B., et al. 2004. Molecular and Cellular Biology 24, 8374.
        • Liao, X., et al. 2003. Endocrinology 144, 1656.
          		•
          Data Sheet

          Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

          Revision11-September-2014 JSW
          SynonymsmTOR Inhibitor I
          DescriptionSelectively inhibits the mammalian target of rapamycin (mTOR) and blocks the subsequent activation of p70 S6 kinase (IC50 = 50 pM). Specifically inhibits mTORC1, but mTORC2 that phosphorylates Akt at Ser473 appears to be insensitive to rapamycin. Prevents the translational activation of IGF-II. Also prevents resting T-cells from entering the cell cycle, but does not directly arrest cell cycle progression. Shown to inhibit later signaling events, such as p110Rb phosphorylation, p34cdc2 kinase activation, and cyclin A synthesis. Exhibits strong binding to FK-506 binding proteins. Also reported to induce apoptosis in a murine B-cell line, to inhibit lymphokine-induced cell proliferation at the G1 phase, and to irreversibly arrest Saccharomyces cerevisiae cells in the G1 phase.
          FormClear film
          CAS number53123-88-9
          RTECSVE6250000
          Chemical formulaC₅₁H₇₉NO₁₃
          Structure formulaStructure formula
          Purity≥99% by HPLC
          SolubilityDMSO (200 mg/ml) or Ethanol (50 mg/ml)
          Storage -20°C
          Do Not Freeze Ok to freeze
          Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
          Toxicity Standard Handling
          Merck USA index14, 8114
          ReferencesChen, T., et al. 2011. Aging Cell. 10, 908.
          Powell, D.J., et al. 2003. Mol. cell Biol. 23, 7794.
          Braun, W., et al. 1995. FASEB J. 9, 63.
          Nielsen, F.C., et al. 1995. Nature 377, 358.
          Aagaard-Tillery, K.M. and Jelinek, D.F. 1994. Cell. Immunol. 156, 493.
          Gottschalk, A.R., et al. 1994. Proc. Natl. Acad. Sci. USA 91, 7350.
          Morice, W.G., et al. 1993. J. Biol. Chem. 268, 3734.
          Terada, N., et al. 1993. J. Biol. Chem. 268, 12062.
          Kuo, J., et al. 1992. Nature 358, 70.
          Price, D.J., et al. 1992. Science 257, 973.
          Heitman, J., et al. 1991. Science 253, 905.
          Kay, J.E., et al. 1991. Immunology 72, 544.
          Schreiber, S.L. 1991. Science 251, 283.
          Bierer, B.E., et al. 1990. Proc. Natl. Acad. Sci. USA 87, 9231.
          Dumont, F.J., et al. 1990. J. Immunol. 144, 251.
          Citation
        • Chen, T., et al. 2011. Aging Cell. 10, 908.
        • Yu, YL., et al. 2005. Journal of Biological Chemistry 280, 29533.
        • Vega, R.B., et al. 2004. Molecular and Cellular Biology 24, 8374.
        • Liao, X., et al. 2003. Endocrinology 144, 1656.
          		•