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476300 Myriocin, Mycelia sterilia - CAS 35891-70-4 - Calbiochem

Overview

Key Spec Table

CAS #Empirical Formula
35891-70-4C₂₁H₃₉NO₆

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476300-5MGCN
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      Description
      OverviewA potent immunosuppressant. Displays 10- to 100-fold more potent immunosuppressant activity than cyclosporin A. Potently inhibits serine palmitoyltransferase (SPT; Ki = 280 pM) thereby blocking the synthesis of ceramide. Disrupts substratum adhesion of melanoma cells. Inhibits cell proliferation and induces apoptosis in IL-2 dependent murine cytotoxic T lymphocyte cell line CTLL-2.
      Catalogue Number476300
      Brand Family Calbiochem®
      SynonymsISP-1, Thermozymocidin, [2S,3R,4R]-(E)-2-Amino-3,4-dihydroxy-2-[hydroxymethyl]-14-oxo-6-eicosenoic Acid
      References
      ReferencesHanada, K., et al. 2000. Biochem. Pharmacol. 59, 1211.
      Chen, J.K., et al. 1999. Chem. Biol. 6, 221.
      Hidari, K.I.P.J., et al. 1996. J. Biol. Chem. 271, 14636.
      Nakamura, S., et al. 1996. J. Biol. Chem. 271, 1255.
      Mikaye, Y., et al. 1995. Biochem. Biophys. Res. Commun. 211, 396.
      Fujita, T., et al. 1994. J. Antibiot. 47, 208.
      Product Information
      CAS number35891-70-4
      ATP CompetitiveN
      FormWhite to off-white solid
      Hill FormulaC₂₁H₃₉NO₆
      Chemical formulaC₂₁H₃₉NO₆
      ReversibleN
      Structure formula ImageStructure formula Image
      Quality LevelMQ100
      Biological Information
      Primary TargetSerine palmitoyltransferase
      Primary Target K<sub>i</sub>280 pM against serine palmitoyltransferase
      Purity≥95% by TLC
      Physicochemical Information
      Cell permeableN
      Safety Information according to GHS
      RTECSJX3890000
      Safety Information
      R PhraseR: 22

      Harmful if swallowed.
      S PhraseS: 36

      Wear suitable protective clothing.
      Storage and Shipping Information
      Ship Code Ambient Temperature Only
      Toxicity Harmful
      Storage -20°C
      Do not freeze Ok to freeze
      Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
      Global Trade Item Number
      Catalogue Number GTIN
      476300-5MGCN 04055977183801