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FCMAB194F Milli-Mark™ Anti-CD38-FITC Antibody, clone AT13/5

Milli-Mark Anti-CD38-FITC Antibody, clone AT13/5 is an antibody against CD38 for use in FC.

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Research Category: Inflammation & Immunology Research Sub-Category: Immunoglobulins & Immunology UniProt Number: P28907
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FCMAB194F
100 tests  
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      Overview

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      Key Spec Table

      Species ReactivityKey ApplicationsHostFormatAntibody Type
      HFCMFITCMonoclonal Antibody
      Description
      Catalogue NumberFCMAB194F
      Trade Name
      • Milli-Mark
      DescriptionMilli-Mark™ Anti-CD38-FITC Antibody, clone AT13/5
      Alternate Names
      • ADP-ribosyl cyclase 1
      • Cyclic ADP-ribose hydrolase 1
      • cADPr hydrolase 1
      • T10
      Background InformationCD38 is a 45 kDa type II integral membrane glycoprotein consisting of an N-terminal 20 amino acid cytoplasmic domain, a 23 amino acid transmembrane domain, and a 257 amino acid extracellular domain. CD38 is associated with different molecules in different cell types and these unique combinations cause unique cell-type specific signaling. One of the known ligands that activates CD38-mediated signaling is CD31 (Deaglio, 2001). CD38 is expressed by a number of different cell types and the pattern of expression often changes with differentiation and maturation. Thus, CD38 expression is found during early stages of B and T-cell differentiation, is lacking during the later intermediate stages, and is regained near the end of maturation. CD38 is expressed at variable levels on the majority of hematopoietic cells, prevalently during early differentiation and activation, and it is expressed strongly on plasma cells (Jackson, 1990; Terstappen, 1990; Morra, 1997). CD38-postive cell types outside the hematopoietic system include subsets from the gut, brain, prostate, pancreas, bone, eye, and muscle (Deaglio, 2001). CD38 is expressed on approximately 60% of CD34-positive peripheral blood mononuclear cells. The least mature CD34-postive cells are characterized by a lack of CD38 (Herbein, 1994).
      Anti-CD38, AT13/5 was included in the Sixth International Workshop and Conference on Human Leucocyte Differentiation Antigens, and studies by a number of laboratories confirmed its reactivity with CD38 (Morra, 1997).
      Product Information
      FormatFITC
      Control
      • Human Lymphocytes
      PresentationPurified Mouse monoclonal IgG1 conjugated to FITC in 0.05M Tris-HCl buffer with 1% BSA, Sodium Azide at 0.097% at pH 7.2.
      Quality LevelMQ100
      Applications
      ApplicationMilli-Mark Anti-CD38-FITC Antibody, clone AT13/5 is an antibody against CD38 for use in FC.
      Key Applications
      • Flow Cytometry
      Biological Information
      ImmunogenNamalwa cells (B lymphocyte cell line from Burkitt's lymphoma)
      CloneAT13/5
      HostMouse
      SpecificityAntibody recognizes Human CD38 antigen.
      IsotypeIgG1κ
      Species Reactivity
      • Human
      Antibody TypeMonoclonal Antibody
      Entrez Gene Number
      Entrez Gene SummaryCD38 is a novel multifunctional ectoenzyme widely expressed in cells and tissues especially in leukocytes. CD38 also functions in cell adhesion,signal transduction and calcium signaling.
      Purification MethodProtein A Purfied
      UniProt Number
      UniProt SummarySynthesizes cyclic ADP-ribose, a second messenger for glucose-induced insulin secretion. Also has cADPr hydrolase activity. Also moonlights as a receptor in cells of the immune system. Expressed at high levels in pancreas, liver, kidney, brain, testis, ovary, placenta, malignant lymphoma and neuroblastoma. Preferentially expressed at both early and late stages of the B and T-cell maturation. It is also detected on erythroid and myeloid progenitors in bone marrow, where the level of surface expression was shown to decrease during differentiation of blast-forming unit E to colony-forming unit E.
      Molecular Weight 45 kDa (Deaglio, 2001)
      Product Usage Statements
      Quality AssuranceEvaluated by flow cytometry using human lymphocytes
      Usage Statement
      • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
      Storage and Shipping Information
      Storage ConditionsMaintain refrigerated at 2-8°C protected from light in undiluted aliquots for up to 6 months from date of receipt.
      Packaging Information
      Material Size100 tests
      Global Trade Item Number
      Catalogue Number GTIN
      FCMAB194F 04053252480324