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475864 MK-2 Inhibitor III - CAS 1186648-22-5 - Calbiochem

MK-2 Inhibitor III, CAS 1186648-22-5, is a cell-permeable, ATP-competitive inhibitor of MK-2/MAPKAP-K2 (IC50 = 8.5, 81 & 210 nM against MK-2, MK-5 & MK-3, respectively).

MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.

Synonyms: 2-(2-Quinolin-3-ylpyridin-4-yl)-1,5,6,7-tetrahydro-4H-pyrrolo-[3,2-c]pyridin-4-one

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475864
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Overview

Replacement Information

Key Spec Table

CAS #Empirical Formula
1186648-22-5C₂₁H₁₆N₄O • H₂O

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      Description
      OverviewA cell-permeable pyrrolopyridinyl compound that acts as an ATP-competitive inhibitor of MK-2/MAPKAP-K2 (IC50 = 8.5, 81, and 210 nM against MK-2, MK-5, and MK-3, respectively), while exhibiting much less or no activity against 8 other commonly studied kinases. Shown to suppress LPS-induced TNF-α production in U937 cells (IC50 = 4.4 µM).
      Catalogue Number475864
      Brand Family Calbiochem®
      Synonyms2-(2-Quinolin-3-ylpyridin-4-yl)-1,5,6,7-tetrahydro-4H-pyrrolo-[3,2-c]pyridin-4-one
      References
      ReferencesAnderson, D.R., et al. 2007. J. Med. Chem. 50, 2647.
      Product Information
      CAS number1186648-22-5
      FormPale yellow solid
      Hill FormulaC₂₁H₁₆N₄O • H₂O
      Chemical formulaC₂₁H₁₆N₄O • H₂O
      Structure formula ImageStructure formula Image
      Quality LevelMQ100
      Applications
      ApplicationMK-2 Inhibitor III, CAS 1186648-22-5, is a cell-permeable, ATP-competitive inhibitor of MK-2/MAPKAP-K2 (IC50 = 8.5, 81 & 210 nM against MK-2, MK-5 & MK-3, respectively).
      Biological Information
      Purity≥97% by HPLC
      Physicochemical Information
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      Product Usage Statements
      Storage and Shipping Information
      Ship Code Ambient Temperature Only
      Toxicity Standard Handling
      Storage +2°C to +8°C
      Protect from Light Protect from light
      Do not freeze Ok to freeze
      Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.
      Packaging Information
      Packaged under inert gas Packaged under inert gas
      Transport Information
      Supplemental Information
      Specifications
      Global Trade Item Number
      Catalogue Number GTIN
      475864-5MGCN 04055977203400

      Documentation

      MK-2 Inhibitor III - CAS 1186648-22-5 - Calbiochem SDS

      Title

      Safety Data Sheet (SDS) 

      MK-2 Inhibitor III - CAS 1186648-22-5 - Calbiochem Certificates of Analysis

      TitleLot Number
      475864

      References

      Reference overview
      Anderson, D.R., et al. 2007. J. Med. Chem. 50, 2647.
      Data Sheet

      Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

      Revision13-April-2011 RFH
      Synonyms2-(2-Quinolin-3-ylpyridin-4-yl)-1,5,6,7-tetrahydro-4H-pyrrolo-[3,2-c]pyridin-4-one
      DescriptionA cell-permeable pyrrolopyridinyl compound that acts as a potent, selective, and ATP-biniding site-targeting MK-2/MAPKAP-K2 inhibitor (IC50 = 8.5, 81, and 210 nM agaisnt MK-2, MK-5, and MK-3, respectively), while exhibiting much less or no activity against 8 other commonly studied kinases. Shown to suppress LPS-induced TNF-α production in U937 cells (IC50 = 4.4 µM).
      FormPale yellow solid
      Intert gas (Yes/No) Packaged under inert gas
      CAS number1186648-22-5
      Chemical formulaC₂₁H₁₆N₄O • H₂O
      Structure formulaStructure formula
      Purity≥97% by HPLC
      SolubilityDMSO (50 mg/ml)
      Storage Protect from light
      +2°C to +8°C
      Do Not Freeze Ok to freeze
      Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.
      Toxicity Standard Handling
      ReferencesAnderson, D.R., et al. 2007. J. Med. Chem. 50, 2647.