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474787 MG-132, ≥95% by HPLC - CAS 133407-82-6 - Calbiochem

MG-132, ≥95% by HPLC, CAS 133407-82-6, is a potent, reversible, and cell-permeable proteasome inhibitor (Ki = 4 nM).

MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.

Synonyms: Proteasome Inhibitor XI, Z-Leu-Leu-Leu-CHO, Carbobenzoxy-L-leucyl-L-leucyl-L-leucinal

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474787
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Overview

Replacement Information

Key Spec Table

CAS #Empirical Formula
133407-82-6C₂₆H₄₁N₃O₅

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474787-10MGCN
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      Description
      OverviewPotent, reversible, and cell-permeable proteasome inhibitor (Ki = 4 nM). Reduces the degradation of ubiquitin-conjugated proteins in mammalian cells and permeable stains of yeast by the 26S complex without affecting its ATPase or isopeptidase activities. Activates c-Jun N-terminal kinase (JNK1) which initiates apoptosis. Inhibits NF-κB activation (IC50 = 3 µM). This material is ≥95% pure by HPLC. A material with ≥98% purity by HPLC (Cat. No. 474790) is also available. Also available as a 20 mM solution in DMSO (Cat. No. 474788).
      Catalogue Number474787
      Brand Family Calbiochem®
      SynonymsProteasome Inhibitor XI, Z-Leu-Leu-Leu-CHO, Carbobenzoxy-L-leucyl-L-leucyl-L-leucinal
      References
      ReferencesSteinhilb, M.L., et al. 2001. J. Biol. Chem. 276, 4476.
      Meriin, A.B., et al. 1998. J. Biol. Chem. 273, 6373.
      Adams, J., and Stein, R. 1996. Ann. Rep. Med. Chem. 31, 279.
      Klafki, H.W., et al. 1996. J. Biol. Chem. 271, 2865.
      Lee, D.H., and Goldberg, A.L., 1996. J. Biol. Chem. 271, 27280.
      Wiertz, E.J., et al. 1996. Cell 84, 769.
      Jensen, T.J., et al. 1995. Cell 83, 129.
      Read, M.A., et al. 1995. Immunity 2, 493.
      Rock, K.L., et al. 1994. Cell 78, 761.
      Product Information
      CAS number133407-82-6
      FormWhite powder
      Hill FormulaC₂₆H₄₁N₃O₅
      Chemical formulaC₂₆H₄₁N₃O₅
      Structure formula ImageStructure formula Image
      Quality LevelMQ100
      Applications
      ApplicationMG-132, ≥95% by HPLC, CAS 133407-82-6, is a potent, reversible, and cell-permeable proteasome inhibitor (Ki = 4 nM).
      Biological Information
      Purity≥95% by HPLC
      Physicochemical Information
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      Product Usage Statements
      Storage and Shipping Information
      Ship Code Ambient Temperature Only
      Toxicity Standard Handling
      Storage -20°C
      Protect from Light Protect from light
      Do not freeze Ok to freeze
      Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
      Packaging Information
      Packaged under inert gas Packaged under inert gas
      Transport Information
      Supplemental Information
      Specifications
      Global Trade Item Number
      Catalogue Number GTIN
      474787-10MGCN 04055977185454

      Documentation

      MG-132, ≥95% by HPLC - CAS 133407-82-6 - Calbiochem Certificates of Analysis

      TitleLot Number
      474787

      References

      Reference overview
      Steinhilb, M.L., et al. 2001. J. Biol. Chem. 276, 4476.
      Meriin, A.B., et al. 1998. J. Biol. Chem. 273, 6373.
      Adams, J., and Stein, R. 1996. Ann. Rep. Med. Chem. 31, 279.
      Klafki, H.W., et al. 1996. J. Biol. Chem. 271, 2865.
      Lee, D.H., and Goldberg, A.L., 1996. J. Biol. Chem. 271, 27280.
      Wiertz, E.J., et al. 1996. Cell 84, 769.
      Jensen, T.J., et al. 1995. Cell 83, 129.
      Read, M.A., et al. 1995. Immunity 2, 493.
      Rock, K.L., et al. 1994. Cell 78, 761.
      Data Sheet

      Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

      Revision26-March-2012 JSW
      SynonymsProteasome Inhibitor XI, Z-Leu-Leu-Leu-CHO, Carbobenzoxy-L-leucyl-L-leucyl-L-leucinal
      DescriptionPotent, reversible, and cell-permeable proteasome inhibitor (Ki = 4 nM). Reduces the degradation of ubiquitin-conjugated proteins in mammalian cells and permeable stains of yeast by the 26S complex without affecting its ATPase or isopeptidase activities. Activates c-Jun N-terminal kinase (JNK1) which initiates apoptosis. Inhibits NF-κB activation (IC50 = 3 µM). This material is ≥95% pure by HPLC. A material with ≥98% purity by HPLC (Cat. No. 474790) is also available.
      FormWhite powder
      Intert gas (Yes/No) Packaged under inert gas
      CAS number133407-82-6
      Chemical formulaC₂₆H₄₁N₃O₅
      Structure formulaStructure formula
      Purity≥95% by HPLC
      SolubilityDMSO (25 mg/ml) or Ethanol (25 mg/ml)
      Storage Protect from light
      -20°C
      Do Not Freeze Ok to freeze
      Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
      Toxicity Standard Handling
      ReferencesSteinhilb, M.L., et al. 2001. J. Biol. Chem. 276, 4476.
      Meriin, A.B., et al. 1998. J. Biol. Chem. 273, 6373.
      Adams, J., and Stein, R. 1996. Ann. Rep. Med. Chem. 31, 279.
      Klafki, H.W., et al. 1996. J. Biol. Chem. 271, 2865.
      Lee, D.H., and Goldberg, A.L., 1996. J. Biol. Chem. 271, 27280.
      Wiertz, E.J., et al. 1996. Cell 84, 769.
      Jensen, T.J., et al. 1995. Cell 83, 129.
      Read, M.A., et al. 1995. Immunity 2, 493.
      Rock, K.L., et al. 1994. Cell 78, 761.