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440205 LY 83583 - CAS 91300-60-6 - Calbiochem

A cell-permeable, competitive inhibitor of soluble guanylate cyclase (IC₅₀ = 2 µM).

LY 83583 - CAS 91300-60-6 - Calbiochem MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.

Synonyms: 6-Anilino-5,8-quinolinequinone

Primary Target: soluble guanylate cyclase
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440205
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Overview

Replacement Information

Key Spec Table

CAS #Empirical Formula
91300-60-6C₁₅H₁₀N₂O₂

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      Description
      OverviewA cell-permeable, competitive inhibitor of soluble guanylate cyclase (IC50 = 2 µM). Lowers the production of cGMP levels in a wide range of tissues by blocking intracellular Ca2+ release, with negligible effect on cAMP levels. Inhibits nitric oxide-induced smooth muscle relaxation. Shown to inhibit interleukin-1-induced cGMP accumulation in cultured rat aortic vascular smooth muscle cells. Also inhibits neutrophil chemotaxis induced by NO donors.
      Catalogue Number440205
      Brand Family Calbiochem®
      Synonyms6-Anilino-5,8-quinolinequinone
      References
      ReferencesAdachi, R., et al. 2000. Int. J. Immunopharmacol. 22, 855.
      Kawada, T., et al. 1994. Gen. Pharmacol. 25, 1361.
      Beasley, D., et al. 1991. J. Clin. Invest. 87, 602.
      Pandol, S.J., et al. 1990. J. Biol. Chem. 265, 12846.
      Light, D.B., et al. 1989. Science 243, 383.
      Mulsch, A. 1988. J. Pharmacol. Exp. Ther. 247, 283.
      Fleisch, J.H., et al. 1984. J. Pharmacol. Exp. Ther. 229, 681.
      Product Information
      CAS number91300-60-6
      ATP CompetitiveN
      FormReddish purple solid
      Hill FormulaC₁₅H₁₀N₂O₂
      Chemical formulaC₁₅H₁₀N₂O₂
      ReversibleN
      Structure formula ImageStructure formula Image
      Quality LevelMQ100
      Applications
      Biological Information
      Primary Targetsoluble guanylate cyclase
      Primary Target IC<sub>50</sub>2 µM against soluble guanylate cyclase
      Purity≥98% by HPLC
      Physicochemical Information
      Cell permeableY
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      R PhraseR: 22-36/37/38-45-46-48

      Harmful if swallowed.
      Irritating to eyes, respiratory system and skin.
      May cause cancer.
      May cause heritable genetic damage.
      Danger of serious damage to health by prolonged exposure.
      S PhraseS: 22-26-36/37/39-45

      Do not breathe dust.
      In case of contact with eyes, rinse immediately with plenty of water and seek medical advice.
      Wear suitable protective clothing, gloves and eye/face protection.
      In case of accident or if you feel unwell, seek medical advice immediately (show the label where possible).
      Product Usage Statements
      Storage and Shipping Information
      Ship Code Ambient Temperature Only
      Toxicity Harmful & Carcinogenic / Teratogenic
      Storage +2°C to +8°C
      Do not freeze Ok to freeze
      Special InstructionsFollowing reconstitution, store in the refrigerator (4°C). Stock solutions are stable for up to 1 month at 4°C or up to 6 months at -20°C.
      Packaging Information
      Transport Information
      Supplemental Information
      Specifications
      Global Trade Item Number
      Catalogue Number GTIN
      440205-5MGCN 04055977186727

      Documentation

      LY 83583 - CAS 91300-60-6 - Calbiochem SDS

      Title

      Safety Data Sheet (SDS) 

      LY 83583 - CAS 91300-60-6 - Calbiochem Certificates of Analysis

      TitleLot Number
      440205

      References

      Reference overview
      Adachi, R., et al. 2000. Int. J. Immunopharmacol. 22, 855.
      Kawada, T., et al. 1994. Gen. Pharmacol. 25, 1361.
      Beasley, D., et al. 1991. J. Clin. Invest. 87, 602.
      Pandol, S.J., et al. 1990. J. Biol. Chem. 265, 12846.
      Light, D.B., et al. 1989. Science 243, 383.
      Mulsch, A. 1988. J. Pharmacol. Exp. Ther. 247, 283.
      Fleisch, J.H., et al. 1984. J. Pharmacol. Exp. Ther. 229, 681.

      Brochure

      Title
      Pathways and Biomarkers of Oxidative Stress
      Data Sheet

      Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

      Revision01-February-2024 JSW
      Synonyms6-Anilino-5,8-quinolinequinone
      DescriptionA cell-permeable, competitive inhibitor of soluble guanylate cyclase (IC50 = 2 µM). Lowers the production of cGMP levels in a wide range of tissues by blocking intracellular Ca2+ release, with negligible effect on cAMP levels. Inhibits nitric oxide-induced smooth muscle relaxation. Shown to inhibit interleukin-1-induced cGMP accumulation in cultured rat aortic vascular smooth muscle cells.
      FormReddish purple solid
      CAS number91300-60-6
      Chemical formulaC₁₅H₁₀N₂O₂
      Structure formulaStructure formula
      Purity≥98% by HPLC
      SolubilityAcetone or Ethanol (3 mg/ml)
      Storage +2°C to +8°C
      Do Not Freeze Ok to freeze
      Special InstructionsFollowing reconstitution, store in the refrigerator (4°C). Stock solutions are stable for up to 1 month at 4°C or up to 6 months at -20°C.
      Toxicity Harmful & Carcinogenic / Teratogenic
      ReferencesAdachi, R., et al. 2000. Int. J. Immunopharmacol. 22, 855.
      Kawada, T., et al. 1994. Gen. Pharmacol. 25, 1361.
      Beasley, D., et al. 1991. J. Clin. Invest. 87, 602.
      Pandol, S.J., et al. 1990. J. Biol. Chem. 265, 12846.
      Light, D.B., et al. 1989. Science 243, 383.
      Mulsch, A. 1988. J. Pharmacol. Exp. Ther. 247, 283.
      Fleisch, J.H., et al. 1984. J. Pharmacol. Exp. Ther. 229, 681.