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407951 Ionomycin, Free Acid, Streptomyces conglobatus in Solution - CAS 56092-81-0 - Calbiochem

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407951
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Overview

Replacement Information

Key Spec Table

CAS #Empirical Formula
56092-81-0C₄₁H₇₂O₉

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407951-1MGCN
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      		 Plastic ampoule 1 mg
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      Description
      Catalogue Number407951
      Brand Family Calbiochem®
      References
      ReferencesAagaard-Tillery, K.M., and Jelinek, D.F. 1995. J. Immunol. 155, 3297.
      Takei, N., and Endo, Y. 1994. Brain Res. 652, 65.
      Dupuy d’Angeac, A., et al. 1993. J. Cell Physiol. 154, 44.
      Lee, H.C. 1993. J. Biol. Chem. 268, 293.
      Kuznetsov, G., et al. 1992. J. Biol. Chem. 267, 3932.
      Toeplitz, B.K., et al. 1979. J. Am. Chem. Soc. 101, 3344.
      Liu, C.M., and Hermann, T.E. 1978. J. Biol. Chem. 253, 5892.
      Product Information
      CAS number56092-81-0
      ATP CompetitiveN
      FormClear, colorless to slight yellow solution
      FormulationA 5 mM (1 mg/282 µl) solution of Ionomycin, Free Acid, Streptomyces conglobatus (Cat. No. 407950) in DMSO.
      Hill FormulaC₄₁H₇₂O₉
      Chemical formulaC₄₁H₇₂O₉
      Hygroscopic Hygroscopic
      ReversibleN
      Structure formula ImageStructure formula Image
      Quality LevelMQ100
      Applications
      Biological Information
      Primary TargetMobile ion carrier for Ca2+.
      Purity≥90% by HPLC
      Physicochemical Information
      Cell permeableY
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      Product Usage Statements
      Storage and Shipping Information
      Ship Code Shipped with Blue Ice or with Dry Ice
      Toxicity Irritant
      Storage -20°C
      Protect from Light Protect from light
      Hygroscopic Hygroscopic
      Do not freeze Ok to freeze
      Special InstructionsFollowing initial thaw, aliquot and freeze (-20°C).
      Packaging Information
      Packaged under inert gas Packaged under inert gas
      Transport Information
      Supplemental Information
      Specifications
      Global Trade Item Number
      Catalogue Number GTIN
      407951-1MGCN 04055977211580

      Documentation

      Ionomycin, Free Acid, Streptomyces conglobatus in Solution - CAS 56092-81-0 - Calbiochem SDS

      Title

      Safety Data Sheet (SDS) 

      Ionomycin, Free Acid, Streptomyces conglobatus in Solution - CAS 56092-81-0 - Calbiochem Certificates of Analysis

      TitleLot Number
      407951

      References

      Reference overview
      Aagaard-Tillery, K.M., and Jelinek, D.F. 1995. J. Immunol. 155, 3297.
      Takei, N., and Endo, Y. 1994. Brain Res. 652, 65.
      Dupuy d’Angeac, A., et al. 1993. J. Cell Physiol. 154, 44.
      Lee, H.C. 1993. J. Biol. Chem. 268, 293.
      Kuznetsov, G., et al. 1992. J. Biol. Chem. 267, 3932.
      Toeplitz, B.K., et al. 1979. J. Am. Chem. Soc. 101, 3344.
      Liu, C.M., and Hermann, T.E. 1978. J. Biol. Chem. 253, 5892.

      Citations

      Title
    • Jonathan Rios-Doria, et al. (2004) Cleavage of b-catenin by calpain in prostate and mammary tumor cells. Cancer Research 64, 7237-7240.
      		•
      Data Sheet

      Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

      Revision01-April-2011 RFH
      DescriptionHighly specific for divalent cations (Ca2+ > Mg2+ >> Sr2+ = Ba2+). More effective than antibiotic A23187 as a mobile ion carrier for Ca2+. Complexes with Ca2+ between pH 7 and 9.5, causing significant absorption in the UV range; however, in contrast to A23187 (Cat. No. 100105), it is not fluorescent. Useful for studies of Ca2+ transport across biological membranes and measurement of cytoplasmic free Ca2+. Induces apoptotic neuronal degeneration in embryonic cortical neurons. Also induces cell cycle arrest in the G1 interval of mature Burkitt lymphoma cell lines.
      FormClear, colorless to slight yellow solution
      FormulationA 5 mM (1 mg/282 µl) solution of Ionomycin, Free Acid, Streptomyces conglobatus (Cat. No. 407950) in DMSO.
      Intert gas (Yes/No) Packaged under inert gas
      CAS number56092-81-0
      Chemical formulaC₄₁H₇₂O₉
      Structure formulaStructure formula
      Purity≥90% by HPLC
      Storage Protect from light
      -20°C
      Hygroscopic
      Do Not Freeze Ok to freeze
      Special InstructionsFollowing initial thaw, aliquot and freeze (-20°C).
      Toxicity Irritant
      ReferencesAagaard-Tillery, K.M., and Jelinek, D.F. 1995. J. Immunol. 155, 3297.
      Takei, N., and Endo, Y. 1994. Brain Res. 652, 65.
      Dupuy d’Angeac, A., et al. 1993. J. Cell Physiol. 154, 44.
      Lee, H.C. 1993. J. Biol. Chem. 268, 293.
      Kuznetsov, G., et al. 1992. J. Biol. Chem. 267, 3932.
      Toeplitz, B.K., et al. 1979. J. Am. Chem. Soc. 101, 3344.
      Liu, C.M., and Hermann, T.E. 1978. J. Biol. Chem. 253, 5892.
      Citation
    • Jonathan Rios-Doria, et al. (2004) Cleavage of b-catenin by calpain in prostate and mammary tumor cells. Cancer Research 64, 7237-7240.
      		•