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405268 Indomethacin - CAS 53-86-1 - Calbiochem

A non-steroidal anti-inflammatory, cell permeable, antipyretic agent.

Indomethacin - CAS 53-86-1 - Calbiochem MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.

Synonyms: 1-(p-Chlorobenzoyl)-5-methoxy-2-methyl-1H-indole-3-acetic Acid

Primary Target: COX-1
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405268
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Overview

Replacement Information

Key Spec Table

CAS #Empirical Formula
53-86-1C₁₉H₁₆ClNO₄

Pricing & Availability

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405268-10GMCN
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      Description
      OverviewA non-steroidal anti-inflammatory, cell permeable, antipyretic agent. Non-selective COX inhibitor (IC50 = 740 nM for COX-1; IC50 = 970 nM for COX-2). Inhibits phospholipase A2 (IC50 = 145 µM). Strongly inhibits insoluble transthyretin (TTR) amyloid fibril formation and suppresses production of Aβ-peptide and secreted form of APP by inhibition of APP mRNA levels in NG108-15 cells.
      Catalogue Number405268
      Brand Family Calbiochem®
      Synonyms1-(p-Chlorobenzoyl)-5-methoxy-2-methyl-1H-indole-3-acetic Acid
      References
      ReferencesKodoyama, K., et al. 2001. Biochem. Biophys. Res. Commun. 281, 483.
      Weggen, S., et al. 2001. Nature 414, 212.
      Kalgutkar, A.S., et al. 2000. Proc. Natl. Acad. Sci. USA 97, 925.
      Klabunde, T., et al. 2000. Nat. Struct. Biol. 7, 312.
      Futaki, N., et al. 1994. Prostaglandins 47, 55.
      Futaki, N., et al. 1994. Prostaglandins 47, 55.
      Stevenson, K.M., and Lumbers, E.R. 1992. J. Dev. Physiol. 17, 257.
      Oliw, E. 1980. Prostaglandins 19, 271.
      Product Information
      CAS number53-86-1
      ATP CompetitiveN
      FormWhite to off-white powder
      Hill FormulaC₁₉H₁₆ClNO₄
      Chemical formulaC₁₉H₁₆ClNO₄
      ReversibleN
      Structure formula ImageStructure formula Image
      Quality LevelMQ100
      Applications
      Biological Information
      Primary TargetCOX-1
      Primary Target IC<sub>50</sub>740 nM
      Purity≥98% by assay
      Physicochemical Information
      Cell permeableY
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      RTECSNL3500000
      Safety Information
      R PhraseR: 28-42/43-63

      Very toxic if swallowed.
      May cause sensitization by inhalation and skin contact.
      Possible risk of harm to the unborn child.
      S PhraseS: 36/37/39-45

      Wear suitable protective clothing, gloves and eye/face protection.
      In case of accident or if you feel unwell, seek medical advice immediately (show the label where possible).
      Product Usage Statements
      Storage and Shipping Information
      Ship Code Ambient Temperature Only
      Toxicity Highly Toxic & Carcinogenic / Teratogenic
      Hazardous Materials Attention: Due to the nature of the Hazardous Materials in this shipment, additional shipping charges may be applied to your order. Certain sizes may be exempt from the additional hazardous materials shipping charges. Please contact your local sales office for more information regarding these charges.
      Storage +15°C to +30°C
      Do not freeze Ok to freeze
      Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.
      Packaging Information
      Transport Information
      Supplemental Information
      Specifications
      Global Trade Item Number
      Catalogue Number GTIN
      405268-10GMCN 04055977188493

      Documentation

      Indomethacin - CAS 53-86-1 - Calbiochem SDS

      Title

      Safety Data Sheet (SDS) 

      Indomethacin - CAS 53-86-1 - Calbiochem Certificates of Analysis

      TitleLot Number
      405268

      References

      Reference overview
      Kodoyama, K., et al. 2001. Biochem. Biophys. Res. Commun. 281, 483.
      Weggen, S., et al. 2001. Nature 414, 212.
      Kalgutkar, A.S., et al. 2000. Proc. Natl. Acad. Sci. USA 97, 925.
      Klabunde, T., et al. 2000. Nat. Struct. Biol. 7, 312.
      Futaki, N., et al. 1994. Prostaglandins 47, 55.
      Futaki, N., et al. 1994. Prostaglandins 47, 55.
      Stevenson, K.M., and Lumbers, E.R. 1992. J. Dev. Physiol. 17, 257.
      Oliw, E. 1980. Prostaglandins 19, 271.
      Data Sheet

      Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

      Revision13-May-2008 RFH
      Synonyms1-(p-Chlorobenzoyl)-5-methoxy-2-methyl-1H-indole-3-acetic Acid
      DescriptionA cell-permeable, non-steroidal anti-inflammatory, anti-pyretic agent. Non-selective cyclooxygenase (COX) inhibitor (IC50 = 740 nM for COX-1; IC50 = 970 nM for COX-2). Inhibits phospholipase A2 (IC50 = 145 µM). Reported to reduce Aβ42 levels independently of COX activity.
      FormWhite to off-white powder
      CAS number53-86-1
      RTECSNL3500000
      Chemical formulaC₁₉H₁₆ClNO₄
      Structure formulaStructure formula
      Purity≥98% by assay
      SolubilityEthanol (20 mg/ml)
      Storage +15°C to +30°C
      Do Not Freeze Ok to freeze
      Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.
      Toxicity Highly Toxic & Carcinogenic / Teratogenic
      Merck USA index14, 4968
      ReferencesKodoyama, K., et al. 2001. Biochem. Biophys. Res. Commun. 281, 483.
      Weggen, S., et al. 2001. Nature 414, 212.
      Kalgutkar, A.S., et al. 2000. Proc. Natl. Acad. Sci. USA 97, 925.
      Klabunde, T., et al. 2000. Nat. Struct. Biol. 7, 312.
      Futaki, N., et al. 1994. Prostaglandins 47, 55.
      Futaki, N., et al. 1994. Prostaglandins 47, 55.
      Stevenson, K.M., and Lumbers, E.R. 1992. J. Dev. Physiol. 17, 257.
      Oliw, E. 1980. Prostaglandins 19, 271.