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474791 InSolution™ MG-132 - CAS 133407-82-6 - Calbiochem

InSolution™ MG-132, CAS 133407-82-6, is provided as a 10 mM solution in DMSO. Acts as a potent, reversible proteasome inhibitor (Ki = 4 nM).

MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.

Synonyms: Carbobenzoxy-L-leucyl-L-leucyl-L-leucinal, Z-LLL-CHO, Proteasome Inhibitor XI

Primary Target: proteasome
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Overview

Key Spec Table

CAS #Empirical Formula
133407-82-6C₂₆H₄₁N₃O₅

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      474791-5MGCN
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          Description
          Catalogue Number474791
          Brand Family Calbiochem®
          SynonymsCarbobenzoxy-L-leucyl-L-leucyl-L-leucinal, Z-LLL-CHO, Proteasome Inhibitor XI
          References
          ReferencesMeriin, A.B., et al. 1998. J. Biol. Chem. 273, 6373.
          Adams, J., and Stein, R. 1996. Ann. Rep. Med. Chem. 31, 279.
          Lee, D.H., and Goldberg, A.L. 1996. J. Biol. Chem. 271, 27280.
          Wiertz, E.J.H.J., et al. 1996. Cell 84, 769.
          Read, M.A., et al. 1995. Immunity 2, 493.
          Rock, K.L., et al. 1994. Cell 78, 761.
          Product Information
          CAS number133407-82-6
          ATP CompetitiveN
          FormLiquid
          FormulationA 10 mM (1 mg/210 µl) or (5mg/1050 µl) solution of MG-132 (Cat. No. 474790) in DMSO.
          Hill FormulaC₂₆H₄₁N₃O₅
          Chemical formulaC₂₆H₄₁N₃O₅
          ReversibleY
          Quality LevelMQ100
          Biological Information
          Primary Targetproteasome
          Primary Target IC<sub>50</sub>3 µM in inhibiting NF-κB activation
          Primary Target K<sub>i</sub>4 nM as proteasome inhibitor
          Purity≥98% by HPLC
          Physicochemical Information
          Cell permeableY
          Safety Information
          R PhraseR: 36/38

          Irritating to eyes and skin.
          S PhraseS: 26-36-45

          In case of contact with eyes, rinse immediately with plenty of water and seek medical advice.
          Wear suitable protective clothing.
          In case of accident or if you feel unwell, seek medical advice immediately (show the label where possible).
          Storage and Shipping Information
          Ship Code Blue Ice Only
          Toxicity Irritant
          Storage -20°C
          Protect from Light Protect from light
          Do not freeze Ok to freeze
          Special InstructionsFollowing initial thaw, aliquot and freeze (-20°C).
          Packaging Information
          Packaged under inert gas Packaged under inert gas
          Global Trade Item Number
          Catalogue Number GTIN
          474791-1MGCN 04055977185515
          474791-5MGCN 04055977185522