Our broad portfolio consists of multiplex panels that allow you to choose, within the panel, analytes that best meet your needs. On a separate tab you can choose the premixed cytokine format or a single plex kit.
Cell Signaling Kits & MAPmates™
Choose fixed kits that allow you to explore entire pathways or processes. Or design your own kits by choosing single plex MAPmates™, following the provided guidelines.
The following MAPmates™ should not be plexed together:
-MAPmates™ that require a different assay buffer
-Phospho-specific and total MAPmate™ pairs, e.g. total GSK3β and GSK3β (Ser 9)
-PanTyr and site-specific MAPmates™, e.g. Phospho-EGF Receptor and phospho-STAT1 (Tyr701)
-More than 1 phospho-MAPmate™ for a single target (Akt, STAT3)
-GAPDH and β-Tubulin cannot be plexed with kits or MAPmates™ containing panTyr
.
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Select A Species, Panel Type, Kit or Sample Type
To begin designing your MILLIPLEX® MAP kit select a species, a panel type or kit of interest.
Custom Premix Selecting "Custom Premix" option means that all of the beads you have chosen will be premixed in manufacturing before the kit is sent to you.
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96-Well Plate
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Add Additional Reagents (Buffer and Detection Kit is required for use with MAPmates)
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48-602MAG
Buffer Detection Kit for Magnetic Beads
1 Kit
Space Saver Option Customers purchasing multiple kits may choose to save storage space by eliminating the kit packaging and receiving their multiplex assay components in plastic bags for more compact storage.
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Following initial thaw, aliquot and freeze (-20°C). Aliquots are stable for up to 3 months at -20°C. For longer term storage of aliquots, store at -70°C. Use only fresh DMSO for further serial dilutions.
Packaging Information
Packaged under inert gas
Packaged under inert gas
Global Trade Item Number
Catalogue Number
GTIN
197334-5MGCN
04055977206111
Documentation
InSolution™ Bcl-2 Inhibitor VI, ABT-737 - Calbiochem Certificates of Analysis
Title
Lot Number
197334
References
Reference overview
Bardwell, P.D., et al. 2009. J. Immunol.182, 7482. Oltersdorf, T., et al. 2005. Nature435, 677.
Data Sheet
Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.
A cell-permeable nitrophenylsulfonylbenzamide compound that is shown to bind anti-apoptotic Bcl-2 family members Bcl-2, Bcl-XL, and Bcl-w with high affinity (Ki ≤1 nM) and serves as a nonpeptidyl alternative to Bad-derived BH3 peptide (Cat. No. 197220) in preventing the binding and inhibition of the pro- apoptotic by the anti-apoptotic Bcl-2 family proteins. ABT-737 is demonstrated to fully reverse the blockage of Myr-Bid-induced cytochrome c release by Bcl-2 in mitochondria preparations from Bcl-2 overexpressing FL5.12 cells and effectively inhibit the growth of numerous cancer cells both in cultures in vitro (IC50 ≤100 nM against H146 and H1963) and in vivo (complete regression of H146 and H1963 in xenograft mice at 100 mg/kg/day, i.p.). Application of ABT-737 is also demonstrated to significantly reduce the disease severity in several murine models of autoimmunity.
Form
Liquid
Formulation
A 25 mM (5 mg/246 µL) solution of Bcl-2 Inhibitor VI, ABT-737 (Cat. No. 197333) in DMSO.
Intert gas (Yes/No)
Packaged under inert gas
Chemical formula
C₄₂H₄₅ClN₆O₅S₂
Structure formula
Purity
≥97% by HPLC
Storage
Protect from light Avoid freeze/thaw ≤ -70°C Hygroscopic
Do Not Freeze
Ok to freeze
Special Instructions
Following initial thaw, aliquot and freeze (-20°C). Aliquots are stable for up to 3 months at -20°C. For longer term storage of aliquots, store at -70°C. Use only fresh DMSO for further serial dilutions.
Toxicity
Standard Handling
References
Bardwell, P.D., et al. 2009. J. Immunol.182, 7482. Oltersdorf, T., et al. 2005. Nature435, 677.
