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341501 FeTMPyP - Calbiochem

Catalyzes the isomerization of peroxynitrite (ONOO⁻) to nitrate (NO3⁻) under physiological conditions and at realistic dose-derived concentrations (kcat = 2.2 x 10⁶M⁻¹s⁻¹).

FeTMPyP - Calbiochem MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.

Synonyms: 5,10,15,20-Tetrakis(N-methyl-4ʹ-pyridyl)porphinato Iron (III) Chloride, FeIIITMPyP(Cl)

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341501
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Overview

Replacement Information

Key Spec Table

Empirical Formula
C₄₄H₃₆Cl₅FeN₈

Pricing & Availability

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341501-10MGCN
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      		 Plastic ampoule 10 mg
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      Description
      OverviewCatalyzes the isomerization of peroxynitrite (ONOO–) to nitrate (NO3–) under physiological conditions and at realistic dose-derived concentrations (Kcat = 2.2 x 106 M-1s-1). Effectively prevents the oxidation of lipid components by peroxynitrite. Also catalytically decomposes superoxide radicals (O2·). Irradiation of the aqueous solution at 335 nm releases hydroxyl (OH·) radicals. FeTMPyP can also serve as a potential for drug detoxification of reactive oxygen species (ROS).
      Catalogue Number341501
      Brand Family Calbiochem®
      Synonyms5,10,15,20-Tetrakis(N-methyl-4ʹ-pyridyl)porphinato Iron (III) Chloride, FeIIITMPyP(Cl)
      References
      ReferencesLee, J., et al. 1998. J. Am. Chem. Soc. 120, 7493.
      Hunt, J.A., et al. 1997. Chem. Biol. 4, 845.
      Marla, S.S., et al. 1997. Proc. Natl. Acad. Sci. USA 94, 14243.
      Stern, M.K., et al. 1996. J. Am. Chem. Soc. 118, 8735.
      Faraggi, M., et al. 1984. Int. J. Radiat. Biol. Relat. Stud. Phys. Chem. Med. 46, 703.
      Product Information
      ATP CompetitiveN
      FormBrown solid
      Hill FormulaC₄₄H₃₆Cl₅FeN₈
      Chemical formulaC₄₄H₃₆Cl₅FeN₈
      Hygroscopic Hygroscopic
      ReversibleN
      Structure formula ImageStructure formula Image
      Quality LevelMQ100
      Applications
      Biological Information
      Primary TargetPeroxynitrite (ONOO-)
      Primary Target IC<sub>50</sub>Kcat = 2.2 x 106 M-1s-1 in catalyzing the isomerization of peroxynitrite (ONOO-) to nitrate (NO3-) under physiological conditions
      Purity≥90% by TLC
      Physicochemical Information
      Cell permeableN
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      Product Usage Statements
      Storage and Shipping Information
      Ship Code Ambient Temperature Only
      Toxicity Standard Handling
      Storage -20°C
      Protect from Light Protect from light
      Hygroscopic Hygroscopic
      Do not freeze Ok to freeze
      Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 4 months at -20°C.
      Packaging Information
      Transport Information
      Supplemental Information
      Specifications
      Global Trade Item Number
      Catalogue Number GTIN
      341501-10MGCN 04055977215014

      Documentation

      FeTMPyP - Calbiochem SDS

      Title

      Safety Data Sheet (SDS) 

      FeTMPyP - Calbiochem Certificates of Analysis

      TitleLot Number
      341501

      References

      Reference overview
      Lee, J., et al. 1998. J. Am. Chem. Soc. 120, 7493.
      Hunt, J.A., et al. 1997. Chem. Biol. 4, 845.
      Marla, S.S., et al. 1997. Proc. Natl. Acad. Sci. USA 94, 14243.
      Stern, M.K., et al. 1996. J. Am. Chem. Soc. 118, 8735.
      Faraggi, M., et al. 1984. Int. J. Radiat. Biol. Relat. Stud. Phys. Chem. Med. 46, 703.

      Brochure

      Title
      Pathways and Biomarkers of Oxidative Stress
      Data Sheet

      Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

      Revision24-June-2008 RFH
      Synonyms5,10,15,20-Tetrakis(N-methyl-4ʹ-pyridyl)porphinato Iron (III) Chloride, FeIIITMPyP(Cl)
      DescriptionCatalyzes the isomerization of peroxynitrite (ONOO-) to nitrate (NO3-) under physiological conditions and at realistic dose-derived concentrations (Kcat = 2.2 x 106 M-1s-1). Effectively prevents the oxidation of lipid components by peroxynitrite. Also decomposes superoxide radicals (O2•) catalytically. Irradiation of the aqueous solution at 335 nm releases hydroxyl (OH•) radicals. FeTMPyP can also serve as a potential drug for reactive oxygen species (ROS) detoxification.
      FormBrown solid
      Chemical formulaC₄₄H₃₆Cl₅FeN₈
      Structure formulaStructure formula
      Purity≥90% by TLC
      SolubilityH₂O (50 mg/ml)
      Storage Protect from light
      -20°C
      Hygroscopic
      Do Not Freeze Ok to freeze
      Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 4 months at -20°C.
      Toxicity Standard Handling
      ReferencesLee, J., et al. 1998. J. Am. Chem. Soc. 120, 7493.
      Hunt, J.A., et al. 1997. Chem. Biol. 4, 845.
      Marla, S.S., et al. 1997. Proc. Natl. Acad. Sci. USA 94, 14243.
      Stern, M.K., et al. 1996. J. Am. Chem. Soc. 118, 8735.
      Faraggi, M., et al. 1984. Int. J. Radiat. Biol. Relat. Stud. Phys. Chem. Med. 46, 703.