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14-553M EphB2 Protein, active, 250 µg

Active, N-terminal His6-tagged recombinant human EphB2 residues 560-end, for use in Kinase Assays.

EphB2 Protein, active, 250 µg MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.
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14-553M
250 µg  Also available in 10 μg size (cat#14-553) and in bulk (cat# 14-553-K).
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      Overview

      Description
      Catalogue Number14-553M
      Brand Family Upstate
      Trade Name
      • Upstate
      DescriptionEphB2 Protein, active, 250 µg
      OverviewN-terminal His6-tagged recombinant human EphB2 residues 560-end
      Product Information
      Quality LevelMQ100
      Applications
      ApplicationActive, N-terminal His6-tagged recombinant human EphB2 residues 560-end, for use in Kinase Assays.
      Key Applications
      • Kinase Assay
      Biological Information
      SourceHuman EphB2 expressed by baculovirus in Sf21 insect cells
      Specific ActivityFor Specific Activity data, refer to the Certificate of Analysis for individual lots of this enzyme.
      Entrez Gene Number
      Entrez Gene SummaryEphrin receptors and their ligands, the ephrins, mediate numerous developmental processes, particularly in the nervous system. Based on their structures and sequence relationships, ephrins are divided into the ephrin-A (EFNA) class, which are anchored to the membrane by a glycosylphosphatidylinositol linkage, and the ephrin-B (EFNB) class, which are transmembrane proteins. The Eph family of receptors are divided into 2 groups based on the similarity of their extracellular domain sequences and their affinities for binding ephrin-A and ephrin-B ligands. Ephrin receptors make up the largest subgroup of the receptor tyrosine kinase (RTK) family. The protein encoded by this gene is a receptor for ephrin-B family members.
      Gene Symbol
      • EPHB2
      • EphB2
      • CAPB
      • EPHT3
      • Hek5
      • DRT
      • EPTH3
      • TYRO5
      • ERK
      • HEK5
      • MGC87492
      • PCBC
      • Tyro5
      Protein TargetEphB2
      Purification MethodNi2+/NTA-agarose
      Target Sub-FamilyTK
      UniProt Number
      UniProt SummaryFUNCTION: SwissProt: P29323 # Receptor for members of the ephrin-B family. Acts as a tumor suppressor.
      SIZE: 1055 amino acids; 117493 Da
      SUBUNIT: The ligand-activated form interacts with multiple proteins, including GTPase-activating protein (RASGAP) through its SH2 domain. Binds RASGAP through the juxtamembrane tyrosines residues. Interacts with PRKCABP and GRIP1 (By similarity).
      SUBCELLULAR LOCATION: Membrane; Single-pass type I membrane protein.
      TISSUE SPECIFICITY: Brain, heart, lung, kidney, placenta, pancreas, liver and skeletal muscle. Preferentially expressed in fetal brain.
      DISEASE:SwissProt: P29323 # Defects in EPHB2 are involved in the progression of prostate cancer [MIM:176807]. & Defects in EPHB2 are involved in the development of prostate cancer metastasis to the brain [MIM:603688].
      SIMILARITY: SwissProt: P29323 ## Belongs to the protein kinase superfamily. Tyr protein kinase family. Ephrin receptor subfamily. & Contains 2 fibronectin type-III domains. & Contains 1 protein kinase domain. & Contains 1 SAM (sterile alpha motif) domain.
      Molecular Weight52kDa
      Product Usage Statements
      Quality AssuranceRoutinely evaluated by phosphorylation of Poly (Glu4-Tyr) (4:1)
      Usage Statement
      • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
      Storage and Shipping Information
      Storage Conditions6 months at -70°C
      Packaging Information
      Material Size250 µg
      Material PackageAlso available in 10 μg size (cat#14-553) and in bulk (cat# 14-553-K).
      Global Trade Item Number
      Catalogue Number GTIN
      14-553M 04053252284649