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574215 D,L-Sulforaphane - CAS 4478-93-7 - Calbiochem

D,L-Sulforaphane, CAS 4478-93-7, is an anti-tumor agent that acts as a potent inducer of phase II detoxifying enzymes in mouse tissues and murine hepatoma cells in culture.

MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.

Synonyms: 1-Isothiocyanato-4-(methylsulfinyl)butane, R,S-Sulforaphane

Primary Target: Potent inducer of phase II detoxifying enzymes in mouse tissues and murine hepatoma cells in culture
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574215
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Overview

Replacement Information

Key Spec Table

CAS #Empirical Formula
4478-93-7C₆H₁₁NOS₂

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574215-25MGCN
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      		 Plastic ampoule 25 mg
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      Description
      OverviewAn isothiocyanate isolated from broccoli that acts as a potent inducer of phase II detoxifying enzymes in mouse tissues and murine hepatoma cells in culture. It has been shown to be an effective agent in prevention of chemically-induced mammary tumors in rats. It also inhibits the phase I cytochrome P450 isoenzymes 2E1 and IA2 which have been associated with the activation of carcinogens. The induction of phase II enzymes is mediated by mitogen-activated protein kinase (MAPK) pathway.
      Catalogue Number574215
      Brand Family Calbiochem®
      Synonyms1-Isothiocyanato-4-(methylsulfinyl)butane, R,S-Sulforaphane
      References
      ReferencesGamet-Payrastre, L., et al. 2000. Cancer Res. 60, 1426.
      Yu, R., et al. 2000. J. Biol. Chem. 275, 2322.
      Yu, R., et al. 1999. J. Biol. Chem. 274, 27545.
      Barcelo, S., et al. 1998. Mutat. Res. 402, 111.
      Maheo, K., et al. 1997. Cancer Res. 57, 3649.
      Zhang, Y., et al. 1994. Proc. Natl. Acad. Sci. USA 91, 3147.
      Zhang, Y., et al. 1992. Proc. Natl. Acad. Sci. USA 89, 2399.
      Product Information
      CAS number4478-93-7
      ATP CompetitiveN
      FormSlight yellow liquid
      Hill FormulaC₆H₁₁NOS₂
      Chemical formulaC₆H₁₁NOS₂
      ReversibleN
      Structure formula ImageStructure formula Image
      Quality LevelMQ100
      Applications
      ApplicationD,L-Sulforaphane, CAS 4478-93-7, is an anti-tumor agent that acts as a potent inducer of phase II detoxifying enzymes in mouse tissues and murine hepatoma cells in culture.
      Biological Information
      Primary TargetPotent inducer of phase II detoxifying enzymes in mouse tissues and murine hepatoma cells in culture
      Purity≥98% by UPLC
      Physicochemical Information
      Cell permeableN
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      Product Usage Statements
      Storage and Shipping Information
      Ship Code Ambient Temperature Only
      Toxicity Standard Handling
      Storage -20°C
      Protect from Light Protect from light
      Do not freeze Ok to freeze
      Special InstructionsFollowing reconstitution, aliquot and freeze DMSO stock solutions (-20°C) and ethanol stock solutions (-70°C). DMSO stock solutions are stable for up to 3 months at -20°C and ethanol stock solutions are stable for up to 3 months at -70°C.
      Packaging Information
      Packaged under inert gas Packaged under inert gas
      Transport Information
      Supplemental Information
      Specifications
      Global Trade Item Number
      Catalogue Number GTIN
      574215-25MGCN 04055977189568

      Documentation

      D,L-Sulforaphane - CAS 4478-93-7 - Calbiochem Certificates of Analysis

      TitleLot Number
      574215

      References

      Reference overview
      Gamet-Payrastre, L., et al. 2000. Cancer Res. 60, 1426.
      Yu, R., et al. 2000. J. Biol. Chem. 275, 2322.
      Yu, R., et al. 1999. J. Biol. Chem. 274, 27545.
      Barcelo, S., et al. 1998. Mutat. Res. 402, 111.
      Maheo, K., et al. 1997. Cancer Res. 57, 3649.
      Zhang, Y., et al. 1994. Proc. Natl. Acad. Sci. USA 91, 3147.
      Zhang, Y., et al. 1992. Proc. Natl. Acad. Sci. USA 89, 2399.
      Data Sheet

      Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

      Revision26-March-2008 JSW
      Synonyms1-Isothiocyanato-4-(methylsulfinyl)butane, R,S-Sulforaphane
      DescriptionAn isothiocyanate isolated from broccoli that acts as a potent inducer of phase II detoxifying enzymes in mouse tissues and murine hepatoma cells in culture. Shown to be an effective agent in prevention of chemically-induce mammary tumors in rats. Also shown to inhibit the phase I cytochrome P450 isoenzymes 2E1 and IA2 that have been associated with the activation of carcinogens. The induction of phase II enzymes is mediated by the mitogen-activated protein kinase (MAPK) pathway.
      FormSlight yellow liquid
      Intert gas (Yes/No) Packaged under inert gas
      CAS number4478-93-7
      Chemical formulaC₆H₁₁NOS₂
      Structure formulaStructure formula
      Purity≥98% by UPLC
      SolubilityDMSO (20 mg/ml) or ethanol (10 mg/ml)
      Storage Protect from light
      -20°C
      Do Not Freeze Ok to freeze
      Special InstructionsFollowing reconstitution, aliquot and freeze DMSO stock solutions (-20°C) and ethanol stock solutions (-70°C). DMSO stock solutions are stable for up to 3 months at -20°C and ethanol stock solutions are stable for up to 3 months at -70°C.
      Toxicity Standard Handling
      ReferencesGamet-Payrastre, L., et al. 2000. Cancer Res. 60, 1426.
      Yu, R., et al. 2000. J. Biol. Chem. 275, 2322.
      Yu, R., et al. 1999. J. Biol. Chem. 274, 27545.
      Barcelo, S., et al. 1998. Mutat. Res. 402, 111.
      Maheo, K., et al. 1997. Cancer Res. 57, 3649.
      Zhang, Y., et al. 1994. Proc. Natl. Acad. Sci. USA 91, 3147.
      Zhang, Y., et al. 1992. Proc. Natl. Acad. Sci. USA 89, 2399.