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218753 Caspase-5 Inhibitor I

Z-WEHD-FMK is a cell-permeable, potent, irreversible caspase-5 inhibitor, that also inhibits the activity of Caspase 1, 4, and 8.

Caspase-5 Inhibitor I MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.

Synonyms: Z-WE(OMe)HD(OMe)-FMK

Primary Target: caspase-1, caspase-4, caspase-5, caspase-8
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218753
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Overview

Replacement Information

Key Spec Table

Empirical Formula
C₃₇H₄₂FN₇O₁₀

Pricing & Availability

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218753-1MGCN
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      		 Plastic ampoule 1 mg
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      Description
      OverviewA potent, cell-permeable, and irreversible inhibitor of caspase-5. Strongly inhibits caspase-1. Also inhibits caspase-4 and caspase-8.
      Catalogue Number218753
      Brand Family Calbiochem®
      SynonymsZ-WE(OMe)HD(OMe)-FMK
      References
      ReferencesGarcia-Calvo, M., et al. 1998. J. Biol. Chem. 273, 32608.
      Thornberry, N.A., and Lazebnik, Y. 1998. Science 281, 1312.
      Rano, T., et al. 1997. Chem. Biol. 4, 149.
      Product Information
      FormWhite solid
      FormulationSupplied as a trifluoroacetate salt.
      Hill FormulaC₃₇H₄₂FN₇O₁₀
      Chemical formulaC₃₇H₄₂FN₇O₁₀
      ReversibleN
      Quality LevelMQ100
      Applications
      Biological Information
      Primary Targetcaspase-1, caspase-4, caspase-5, caspase-8
      Puritysingle spot by TLC
      Physicochemical Information
      Cell permeableY
      Peptide SequenceZ-Trp-Glu(OMe)-His-Asp(OMe)-CH₂F*
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      Product Usage Statements
      Storage and Shipping Information
      Ship Code Ambient Temperature Only
      Toxicity Standard Handling
      Storage -20°C
      Protect from Moisture Protect from moisture
      Do not freeze Ok to freeze
      Special InstructionsFollowing reconstitution, refrigerate (4°C). Stock solutions are stable for up to 4 months at 4°C.
      Packaging Information
      Transport Information
      Supplemental Information
      Specifications
      Global Trade Item Number
      Catalogue Number GTIN
      218753-1MGCN 04055977219098

      Documentation

      Caspase-5 Inhibitor I SDS

      Title

      Safety Data Sheet (SDS) 

      Caspase-5 Inhibitor I Certificates of Analysis

      TitleLot Number
      218753

      References

      Reference overview
      Garcia-Calvo, M., et al. 1998. J. Biol. Chem. 273, 32608.
      Thornberry, N.A., and Lazebnik, Y. 1998. Science 281, 1312.
      Rano, T., et al. 1997. Chem. Biol. 4, 149.

      Brochure

      Title
      Caspases and other Apoptosis Related Tools Brochure
      Data Sheet

      Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

      Revision02-June-2008 JSW
      SynonymsZ-WE(OMe)HD(OMe)-FMK
      DescriptionA potent, cell-permeable and irreversible inhibitor of caspase-5 (ICErel-III, TY), as well as caspase-1 and caspase-4.
      FormWhite solid
      FormulationSupplied as a trifluoroacetate salt.
      Chemical formulaC₃₇H₄₂FN₇O₁₀
      Peptide SequenceZ-Trp-Glu(OMe)-His-Asp(OMe)-CH₂F*
      Puritysingle spot by TLC
      SolubilityDMSO (5 mg/ml)
      Storage Protect from moisture
      -20°C
      Do Not Freeze Ok to freeze
      Special InstructionsFollowing reconstitution, refrigerate (4°C). Stock solutions are stable for up to 4 months at 4°C.
      Toxicity Standard Handling
      ReferencesGarcia-Calvo, M., et al. 1998. J. Biol. Chem. 273, 32608.
      Thornberry, N.A., and Lazebnik, Y. 1998. Science 281, 1312.
      Rano, T., et al. 1997. Chem. Biol. 4, 149.