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203811 Bryostatin 1 - CAS 83314-01-6 - Calbiochem

A macrocyclic lactone with antitumor properties.

Bryostatin 1 - CAS 83314-01-6 - Calbiochem MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.

Synonyms: Bryo 1, PKC Activator VII, PKC Activator VI

Primary Target: Protein kinase C
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203811
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Overview

Key Spec Table

CAS #Empirical Formula
83314-01-6C₄₇H₆₈O₁₇

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      Description
      OverviewA macrocyclic lactone with antitumor properties. Potently activates protein kinase C and exhibits a high binding affinity (Ki = 1.35 nM). Effectively translocates and down-regulates PKC isozymes α, δ, and ε. Induces a biphasic activation of PKD through a PKC-dependent pathway in intact cells. Also shown to activate Ras in Jurkat T cells and in rat2 cells.
      Catalogue Number203811
      Brand Family Calbiochem®
      SynonymsBryo 1, PKC Activator VII, PKC Activator VI
      References
      ReferencesClamp, A., and Jayson, G. 2002. Anticancer Drugs 13, 673.
      Lorenzo, P.S., et al. 1999. Cancer Res. 59, 6137.
      Wang, Q.J., et al. 1999. J. Biol. Chem. 274, 37233.
      Wender, P.A., et al. 1998. Proc. Natl. Acad. Sci. USA 95, 6624.
      Matthews, S.A., et al. 1997. J. Biol. Chem. 272, 20245.
      Szallasi, Z., et al. 1994. Mol. Pharmacol. 46, 840.
      Berkow, R.L., and Kratt, A.S. 1985. Biochem. Biophys. Res. Commun. 3, 1109.
      Product Information
      CAS number83314-01-6
      ATP CompetitiveN
      FormWhite to colorless solid or film
      Hill FormulaC₄₇H₆₈O₁₇
      Chemical formulaC₄₇H₆₈O₁₇
      ReversibleN
      Structure formula ImageStructure formula Image
      Quality LevelMQ100
      Biological Information
      Primary TargetProtein kinase C
      Primary Target K<sub>i</sub>1.35 nM for protein kinase C
      Purity≥98% by HPLC
      Physicochemical Information
      Cell permeableN
      Safety Information according to GHS
      RTECSEH9455000
      Storage and Shipping Information
      Ship Code Ambient Temperature Only
      Toxicity Standard Handling
      Storage -20°C
      Protect from Light Protect from light
      Do not freeze Ok to freeze
      Special InstructionsFollowing reconstitution aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
      Global Trade Item Number
      Catalogue Number GTIN
      203811-10UGCN 04055977204025