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178220 Antipain, Hydrochloride - CAS 37682-72-7 - Calbiochem

Antipain, Hydrochloride, CAS 37682-72-7, is a peptidyl arginine aldehyde protease inhibitor of trypsin-like serine proteases, papain, and some cysteine proteases (IC50 = 300 µM).

MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.
Primary Target: Trypsin-like serine proteases
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178220
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Overview

Replacement Information

Key Spec Table

CAS #Empirical Formula
37682-72-7C₂₇H₄₄N₁₀O₆ · HCl

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178220-10MGCN
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      		 Plastic ampoule 10 mg
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      178220-5MGCN
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          		 Glass bottle 5 mg
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          Description
          OverviewPeptidyl arginine aldehyde protease inhibitor produced by actinomycetes. Inhibitor of Ca2+-dependent endopeptidases. Has specificity similar to Leupeptin (Cat. No. 108975). Inhibits trypsin-like serine proteases, papain and some cysteine proteases (IC50 = 300 µM).
          Effective concentration: 1-100 µM.
          Catalogue Number178220
          Brand Family Calbiochem®
          References
          ReferencesLyupina, Y.V., et al. 1996. Eur. J. Pharmacol. 304, 23.
          Umezawa, H. 1976. Methods Enzymol. 55, 678.
          Product Information
          CAS number37682-72-7
          ATP CompetitiveN
          FormWhite or slightly yellowish solid
          Hill FormulaC₂₇H₄₄N₁₀O₆ · HCl
          Chemical formulaC₂₇H₄₄N₁₀O₆ · HCl
          Hygroscopic Hygroscopic
          ReversibleN
          Quality LevelMQ100
          Applications
          ApplicationAntipain, Hydrochloride, CAS 37682-72-7, is a peptidyl arginine aldehyde protease inhibitor of trypsin-like serine proteases, papain, and some cysteine proteases (IC50 = 300 µM).
          Biological Information
          Primary TargetTrypsin-like serine proteases
          Primary Target IC<sub>50</sub>300 µM against trypsin-like serine proteases, papain and some cysteine proteases
          Physicochemical Information
          Cell permeableN
          Dimensions
          Materials Information
          Toxicological Information
          Safety Information according to GHS
          RTECSYV9350800
          Safety Information
          Product Usage Statements
          Storage and Shipping Information
          Ship Code Ambient Temperature Only
          Toxicity Standard Handling
          Storage +2°C to +8°C
          Hygroscopic Hygroscopic
          Do not freeze Ok to freeze
          Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C) for long term storage or refrigerate (4°C) for short term storage. Stock solutions are stable for up to 1 week at 4°C or for up to 1 month at -20°C.
          Packaging Information
          Transport Information
          Supplemental Information
          Specifications
          Global Trade Item Number
          Catalogue Number GTIN
          178220-10MGCN 04055977223088
          178220-5MGCN 04055977223095

          Documentation

          Antipain, Hydrochloride - CAS 37682-72-7 - Calbiochem SDS

          Title

          Safety Data Sheet (SDS) 

          Antipain, Hydrochloride - CAS 37682-72-7 - Calbiochem Certificates of Analysis

          TitleLot Number
          178220

          References

          Reference overview
          Lyupina, Y.V., et al. 1996. Eur. J. Pharmacol. 304, 23.
          Umezawa, H. 1976. Methods Enzymol. 55, 678.
          Data Sheet

          Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

          Revision26-September-2007 RFH
          DescriptionPeptidyl arginine aldehyde protease inhibitor produced by actinomycetes. Inhibitor of Ca2+-dependent endopeptidases. Has specificity similar to Leupeptin (Cat. No. 108975). Inhibits trypsin-like serine proteases, papain, and some cysteine proteases (IC50 ~500 ng/ml). Effective at concentrations of 1-100 µM.
          FormWhite or slightly yellowish solid
          CAS number37682-72-7
          RTECSYV9350800
          Chemical formulaC₂₇H₄₄N₁₀O₆ · HCl
          SolubilityH₂O (10 mg/ml)
          Storage +2°C to +8°C
          Hygroscopic
          Do Not Freeze Ok to freeze
          Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C) for long term storage or refrigerate (4°C) for short term storage. Stock solutions are stable for up to 1 week at 4°C or for up to 1 month at -20°C.
          Toxicity Standard Handling
          ReferencesLyupina, Y.V., et al. 1996. Eur. J. Pharmacol. 304, 23.
          Umezawa, H. 1976. Methods Enzymol. 55, 678.