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ABN426 Anti-phospho-Neurogranin (Ser36)/Neuromodulin (Ser41) Antibody

This Anti-phospho-Neurogranin (Ser36)/Neuromodulin (Ser41) Antibody is validated for use in Western Blotting for the detection of phospho-Neurogranin (Ser36)/Neuromodulin (Ser41).

MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.
Research Category: Neuroscience Research Sub-Category: Neuroregenerative Medicine Gene Symbol: Nrgn, neurogranin, Ng, Neurogranin, hng, RC3 UniProt Number: Q04940
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ABN426
100 µg  
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      Overview

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      Key Spec Table

      Species ReactivityKey ApplicationsHostFormatAntibody Type
      MWBRbSerumPolyclonal Antibody
      Description
      Catalogue NumberABN426
      DescriptionAnti-phospho-Neurogranin (Ser36)/Neuromodulin (Ser41) Antibody
      Alternate Names
      • Protein kinase C substrate 7.5 kDa protein RC3
      Background InformationNeurogranin (Ng) (also named RC3, p17 or BICKS) is a small protein originally identified in rat brain and abundantly expressed in several telencephalic areas, such as the cerebral cortex, hippocampus, amygdala, and striatum. In neurons, it is found concentrated at dendritic spines where it participates in synaptic signaling events through the regulation of calmodulin (CaM). Neurogranin protein is a critical third messenger and substrate of PKC in the molecular cascade necessary for synaptic development and remodeling. Neurogranin (Ng) features an IQ motif that mediates its interaction with CaM and phosphatidic acid (PA). The interaction is controlled by phosphorylation at serine 36 of Neurogranin. Neurogranin is phosphorylated at serine 36 by PKC. Ser36-phosphorylated Neurogranin is unable to bind either CaM or PA. Neurogranin in localized in the cell bodies of neurons in the cortex and in the apical and basal dendrites of pyramidal neurons. Neurogranin is not found in dendrites and its expression is very low as well in Alzheimer’s disease patients.
      References
      Product Information
      FormatSerum
      PresentationRabbit Polyclonal serum with 0.05% sodium azide.
      Quality LevelMQ100
      Applications
      ApplicationThis Anti-phospho-Neurogranin (Ser36)/Neuromodulin (Ser41) Antibody is validated for use in Western Blotting for the detection of phospho-Neurogranin (Ser36)/Neuromodulin (Ser41).
      Key Applications
      • Western Blotting
      Biological Information
      ImmunogenKLH-conjugated linear peptide corresponding to the IQ domain of Rat phospho-Neurogranin.
      EpitopeIQ domain
      ConcentrationPlease refer to lot specific datasheet.
      HostRabbit
      SpecificityPhosphorylated Neurogranin and Neuromodulin
      Species Reactivity
      • Mouse
      Species Reactivity NoteMouse. Predicted to react with Rat based on 100% sequence homology.
      Antibody TypePolyclonal Antibody
      Entrez Gene Number
      Gene Symbol
      • Nrgn
      • neurogranin
      • Ng
      • Neurogranin
      • hng
      • RC3
      Modifications
      • Phosphorylation
      Purification MethodUnpurified
      UniProt Number
      Molecular Weight~43 kDa is phospho-Neuromodulin (GAP-43) and ~17 KD is phospho-Neurogranin. Uncharacterized band(s) may appear in some lysates.
      Physicochemical Information
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      Product Usage Statements
      Quality AssuranceEvaluated by Western Blotting in Mouse brain tissue lysate.

      Western Blotting Analysis: A 1:1000 dilution of this antibody detected phospho-Neurogranin (Ser36) / Neuromodulin (Ser41) in 10 µg of Mouse brain tissue lysate treate with magnisium (lane1) or PKC (lane2)
      Usage Statement
      • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
      Storage and Shipping Information
      Storage ConditionsStable for 1 year at -20°C from date of receipt.
      Handling Recommendations: Upon receipt and prior to removing the cap, centrifuge the vial and gently mix the solution. Aliquot into microcentrifuge tubes and store at -20°C. Avoid repeated freeze/thaw cycles, which may damage IgG and affect product performance.
      Packaging Information
      Material Size100 µg
      Transport Information
      Supplemental Information
      Specifications
      Global Trade Item Number
      Catalogue Number GTIN
      ABN426 04053252983559

      Documentation

      Anti-phospho-Neurogranin (Ser36)/Neuromodulin (Ser41) Antibody SDS

      Title

      Safety Data Sheet (SDS) 

      Anti-phospho-Neurogranin (Ser36)/Neuromodulin (Ser41) Antibody Certificates of Analysis

      TitleLot Number
      Anti-phospho-Neurogranin (Ser36)/Neuromodulin (Ser41) - Q2441540 Q2441540
      Anti-phospho-Neurogranin (Ser36)/Neuromodulin (Ser41) - 3250988 3250988
      Anti-phospho-Neurogranin (Ser36)/Neuromodulin (Ser41) - 3753303 3753303
      Anti-phospho-Neurogranin (Ser36)/Neuromodulin (Ser41) - 3860261 3860261
      Anti-phospho-Neurogranin (Ser36)/Neuromodulin (Ser41) - 3928110 3928110