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MABN367 Anti-SV2C Antibody, clone 4C8.1

Anti-SV2C Antibody, clone 4C8.1 is a highly specific mouse monoclonal antibody, that targets SV2C & has been tested in western blotting & IHC.

Anti-SV2C Antibody, clone 4C8.1 MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.
Research Category: Neuroscience Research Sub-Category: Developmental Signaling Gene Symbol: SV2C, KIAA1054 UniProt Number: Q496J9
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MABN367
100 µg  
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      Overview

      Replacement Information

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      Key Spec Table

      Species ReactivityKey ApplicationsHostFormatAntibody Type
      M, HWB, IHCMPurifiedMonoclonal Antibody
      Description
      Catalogue NumberMABN367
      DescriptionAnti-SV2C Antibody, clone 4C8.1
      Alternate Names
      • Synaptic vesicle glycoprotein 2C
      • SV2C
      Background InformationThe protein named Synaptic vesicle glycoprotein 2C (SV2C) and encoded by the human name named SV2C/KAA1054 is glycosylated membrane bound protein important in vesicle secretion. SV2C is part of the major facilitator superfamily of vesicle movement and fusion proteins and is particularly important is vesicle fusion by maintaining a readily releasable pool of secretory granules. Expressed in neural and endocrine cells primarily, SV2C is important for neurotransmission and hormone release. SV2C is enriched in small synaptic vesicles and adrenal microsomes but it is not present in chromaffin granules but is found in insulin granules and microvesicles in the pancreas. In the brain SV2C, in contrast to SV2A and SV2B, expression is restricted to certain regions. High levels of SV2C are found primarily in phylogenetically old brain regions such as the pallidum, the substantia nigra, the midbrain, the brainstem and the olfactory bulb, but SV2C is undetectable in the cerebral cortex and the hippocampus, and found at low levels in the cerebellar cortex. Recent research though also demonstrates that SV2C plays an important role in normal operation of the basal ganglia network and SV2C could also be involved in system adaptation during basal ganglia pathology.
      References
      Product Information
      FormatPurified
      PresentationPurified mouse monoclonal IgG2aκ in buffer containing 0.1 M Tris-Glycine (pH 7.4), 150 mM NaCl with 0.05% sodium azide.
      Quality LevelMQ100
      Applications
      ApplicationAnti-SV2C Antibody, clone 4C8.1 is a highly specific mouse monoclonal antibody, that targets SV2C & has been tested in western blotting & IHC.
      Key Applications
      • Western Blotting
      • Immunohistochemistry
      Application NotesImmunohistochemistry Analysis: A 1:2,000 dilution from a representative lot detected SV2C in human cerebellum and human thalamus tissue.
      Biological Information
      ImmunogenGST-tagged recombinant protein corresponding to the cytoplasmic domain of human SV2C.
      EpitopeCytoplasmic domain
      Clone4C8.1
      ConcentrationPlease refer to the Certificate of Analysis for the lot-specific concentration.
      HostMouse
      IsotypeIgG2aκ
      Species Reactivity
      • Mouse
      • Human
      Antibody TypeMonoclonal Antibody
      Entrez Gene Number
      Gene Symbol
      • SV2C
      • KIAA1054
      Purification MethodProtein G Purified
      UniProt Number
      Molecular Weight~82 kDa observed
      Physicochemical Information
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      Product Usage Statements
      Quality AssuranceEvaluated by Western Blotting in mouse brain tissue lysate.

      Western Blotting Analysis: 0.5 µg/mL of this antibody detected SV2C in 200 µg of mouse brain tissue lysate.
      Usage Statement
      • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
      Storage and Shipping Information
      Storage ConditionsStable for 1 year at 2-8°C from date of receipt.
      Packaging Information
      Material Size100 µg
      Transport Information
      Supplemental Information
      Specifications
      Global Trade Item Number
      Catalogue Number GTIN
      MABN367 04053252934001

      Documentation

      Anti-SV2C Antibody, clone 4C8.1 SDS

      Title

      Safety Data Sheet (SDS) 

      Anti-SV2C Antibody, clone 4C8.1 Certificates of Analysis

      TitleLot Number
      Anti-SV2C, clone 4C8.1 - 3425571 3425571
      Anti-SV2C, clone 4C8.1 - 3597303 3597303
      Anti-SV2C, clone 4C8.1 - 3842854 3842854
      Anti-SV2C, clone 4C8.1 - 4087589 4087589
      Anti-SV2C, clone 4C8.1 - 4194303 4194303
      Anti-SV2C, clone 4C8.1 - Q2301465 Q2301465
      Anti-SV2C, clone 4C8.1 Monoclonal Antibody 3123181

      Brochure

      Title
      New Products Flyer- Feb 2014 - Vol 1