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AB5048P Anti-NMDAR1 Splice Variant C2 Antibody

This Anti-NMDAR1 Splice Variant C2 Antibody is validated for use in IH, WB for the detection of NMDAR1 Splice Variant C2.

Anti-NMDAR1 Splice Variant C2 Antibody MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.
Research Category: Neuroscience Research Sub-Category: Neurotransmitters & Receptors Gene Symbol: GRIN1, Glutamate, NMDAR1, NMDA1, NR1 UniProt Number: Q05586
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AB5048P
25 µg  
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      Overview

      Replacement Information

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      Key Spec Table

      Species ReactivityKey ApplicationsHostFormatAntibody Type
      M, RIHC, WBRbAffinity PurifiedPolyclonal Antibody
      Description
      Catalogue NumberAB5048P
      Brand Family Chemicon®
      Trade Name
      • Chemicon
      DescriptionAnti-NMDAR1 Splice Variant C2 Antibody
      References
      Product Information
      FormatAffinity Purified
      PresentationAffinity purified immunoglobulin. Lyophilized from ammonium bicarbonate (5 mM) so some residual salt may also be present. Reconstitute with 50 μL of PBS. Contains no preservatives.
      Quality LevelMQ100
      Applications
      ApplicationThis Anti-NMDAR1 Splice Variant C2 Antibody is validated for use in IH, WB for the detection of NMDAR1 Splice Variant C2.
      Key Applications
      • Immunohistochemistry
      • Western Blotting
      Application NotesWestern blot: 1:1000 using ECL

      Immunohistochemistry: 1:1,000

      Optimal working dilutions must be determined by the end user.
      Biological Information
      ImmunogenPeptide corresponding to the C-terminus of the rat NMDAR1 C2 splice variant.
      HostRabbit
      SpecificitySpecific for the NMDAR1 C2 splice variants. Recognizes NMDAR-1a, 1b, 2a, and 2b NR1 splice variants. {Gorter et al, (1997), "The Role of Alternative Splicing of the NMDAR1 Receptor Subunit in Synaptic Plasticity" Chapter 4, pg 99, in The Ionotropic Glutamate Receptors , Monaghan, D.T. and Weinhold, R.J. (eds), Humana Press, New Jersey) By Western blot the antibody recognizes a protein with molecular weight of 120 kDa.
      Species Reactivity
      • Mouse
      • Rat
      Antibody TypePolyclonal Antibody
      Entrez Gene Number
      Entrez Gene SummaryThe protein encoded by this gene is a critical subunit of N-methyl-D-aspartate receptors, members of the glutamate receptor channel superfamily which are heteromeric protein complexes with multiple subunits arranged to form a ligand-gated ion channel. These subunits play a key role in the plasticity of synapses, which is believed to underlie memory and learning. Cell-specific factors are thought to control expression of different isoforms, possibly contributing to the functional diversity of the subunits. Alternatively spliced transcript variants have been described.
      Gene Symbol
      • GRIN1
      • Glutamate
      • NMDAR1
      • NMDA1
      • NR1
      UniProt Number
      UniProt SummaryFUNCTION: SwissProt: Q05586 # NMDA receptor subtype of glutamate-gated ion channels with high calcium permeability and voltage-dependent sensitivity to magnesium. Mediated by glycine. This protein plays a key role in synaptic plasticity, synaptogenesis, excitotoxicity, memory acquisition and learning. It mediates neuronal functions in glutamate neurotransmission. Is involved in the cell surface targeting of NMDA receptors (By similarity).
      SIZE: 938 amino acids; 105373 Da
      SUBUNIT: Forms heteromeric channel of a zeta subunit (GRIN1), a epsilon subunit (GRIN2A, GRIN2B, GRIN2C or GRIN2D) and a third subunit (GRIN3A or GRIN3B); disulfide-linked. Found in a complex with GRIN2A or GRIN2B, GRIN3A or GRIN3B and PPP2CB. Interacts with DLG4 and MPDZ (By similarity).
      SUBCELLULAR LOCATION: Cell membrane; Multi-pass membrane protein (By similarity). Note=Enriched in post-synaptic plasma membrane and post-synaptic densities (By similarity).
      PTM: NMDA is probably regulated by C-terminal phosphorylation of an isoform of NR1 by PKC. Dephosphorylated on Ser-897 probably by protein phosphatase 2A (PPP2CB). Its phosphorylated state is influenced by the formation of the NMDAR-PPP2CB complex and the NMDAR channel activity (By similarity).
      SIMILARITY: SwissProt: Q05586 ## Belongs to the glutamate-gated ion channel (TC 1.A.10) family.
      Physicochemical Information
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      Product Usage Statements
      Usage Statement
      • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
      Storage and Shipping Information
      Storage ConditionsMaintain at -20°C in undiluted aliquots for up to 6 months. Avoid repeated freeze/thaw cycles.
      Packaging Information
      Material Size25 µg
      Transport Information
      Supplemental Information
      Specifications
      Global Trade Item Number
      Catalogue Number GTIN
      AB5048P 04053252509445

      Documentation

      Anti-NMDAR1 Splice Variant C2 Antibody SDS

      Title

      Safety Data Sheet (SDS) 

      Anti-NMDAR1 Splice Variant C2 Antibody Certificates of Analysis

      TitleLot Number
      RABBIT ANTI-NMDAR1 C2 SPLICE VARIANT AFFINITY PURIFIED POLYCLONAL ANTIBODY - 2426491 2426491
      RABBIT ANTI-NMDAR1 C2 SPLICE VARIANT AFFINITY PURIFIED POLYCLONAL ANTIBODY - 2458962 2458962
      RABBIT ANTI-NMDAR1 C2 SPLICE VARIANT - 4049856 4049856
      RABBIT ANTI-NMDAR1 C2 SPLICE VARIANT AFFINITY PURIFIED POLYCLONAL ANTIBODY 2953860
      RABBIT ANTI-NMDAR1 C2 SPLICE VARIANT AFFINITY PURIFIED POLYCLONAL ANTIBODY 2961763
      RABBIT ANTI-NMDAR1 C2 SPLICE VARIANT AFFINITY PURIFIED POLYCLONAL ANTIBODY 2984186
      RABBIT ANTI-NMDAR1 C2 SPLICE VARIANT AFFINITY PURIFIED POLYCLONAL ANTIBODY 2919751
      RABBIT ANTI-NMDAR1 C2 SPLICE VARIANT AFFINITY PURIFIED POLYCLONAL ANTIBODY 3002840
      RABBIT ANTI-NMDAR1 C2 SPLICE VARIANT AFFINITY PURIFIED POLYCLONAL ANTIBODY 3143225
      RABBIT ANTI-NMDAR1 C2 SPLICE VARIANT AFFINITY PURIFIED POLYCLONAL ANTIBODY - 2193283 2193283

      References

      Reference overviewPub Med ID
      Heteromeric NMDA receptors: molecular and functional distinction of subtypes.
      Monyer, H, et al.
      Science, 256: 1217-21 (1992)  1992

      Show Abstract       		1350383 1350383

      Brochure

      Title
      Pathways and Biomarkers of Glutamatergic Synapse Flyer

      Data Sheet

      Title
      RABBIT ANTI-NMDAR1 C2 SPLICE VARIANT AFFINITY PURIFIED POLYCLONAL ANTIBODY

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      Categories

      Life Science Research > Antibodies and Assays > Primary Antibodies