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07-2112 Anti-FGFR-4 Antibody

Anti-FGFR-4 Antibody is a highly specific rabbit polyclonal antibody, that targets FGFR4 & has been tested in western blotting.

Anti-FGFR-4 Antibody MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.
Research Category: Signaling Research Sub-Category: Growth Factors & Receptors Gene Symbol: CD334, EC 2.7.10.1 , FGFR-4, JTK2 , MGC20292, OTTHUMP00000161430, TKF UniProt Number: P22455
07-2112
100 µg  
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      Overview

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      Key Spec Table

      Species ReactivityKey ApplicationsHostFormatAntibody Type
      H, M, RWBRbPurifiedPolyclonal Antibody
      Description
      Catalogue Number07-2112
      DescriptionAnti-FGFR-4 Antibody
      Alternate Names
      • CD334 antigen
      • fibroblast growth factor receptor 4
      • hydroxyaryl-protein kinase
      • protein-tyrosine kinase
      • tyrosine kinase related to fibroblast growth factor
        receptor
      • tyrosylprotein kinase
      Background InformationThe protein encoded by this gene is a member of the fibroblast growth factor receptor family, where amino acid sequence is highly conserved between members and throughout evolution. FGFR family members differ from one another in their ligand affinities and tissue distribution. A full-length representative protein would consist of an extracellular region, composed of three immunoglobulin-like domains, a single hydrophobic membrane-spanning segment and a cytoplasmic tyrosine kinase domain. The extracellular portion of the protein interacts with fibroblast growth factors, setting in motion a cascade of downstream signals, ultimately influencing mitogenesis and differentiation.
      References
      Product Information
      FormatPurified
      Control
      • Mouse lung tissue lysate
      PresentationPurified rabbit serum in buffer containing 0.1 M Tris-Glycine (pH7.4) 150 mM NaCl with 0.05% sodium azide.
      Applications
      ApplicationAnti-FGFR-4 Antibody is a highly specific rabbit polyclonal antibody, that targets FGFR4 & has been tested in western blotting.
      Key Applications
      • Western Blotting
      Biological Information
      ImmunogenKLH conjugated linear peptide selected from residues corresponding to human FGFR-4.
      EpitopeUnknown
      ConcentrationPlease refer to the Certificate of Analysis for the lot-specific concentration.
      HostRabbit
      SpecificityThis antibody recognizes FGFR-4.
      Species Reactivity
      • Human
      • Mouse
      • Rat
      Species Reactivity NoteReacts with mouse and rat. 100% homology with human based on sequence homology.
      Antibody TypePolyclonal Antibody
      Entrez Gene Number
      Gene Symbol
      • CD334
      • EC 2.7.10.1
      • FGFR-4
      • JTK2
      • MGC20292
      • OTTHUMP00000161430
      • TKF
      Purification MethodAffinity Purfied
      UniProt Number
      UniProt SummaryFUNCTION: Receptor for acidic fibroblast growth factor. Does not bind to basic fibroblast growth factor. Binds FGF19.
      CATALYTIC ACTIVITY: ATP + a [protein]-L-tyrosine = ADP + a [protein]-L-tyrosine phosphate.
      SUBUNIT STRUCTURE: Interacts with KLB By similarity.
      SUBCELLULAR LOCATION: Membrane; Single-pass type I membrane protein. Note: Isoform 2 may be secreted.
      TISSUE SPECIFICITY: Expressed in gastrointestinal epithelial cells, pancreas, and gastric and pancreatic cancer cell lines.
      PTM: Glycosylated By similarity. Phosphorylated on tyrosine residue By similarity. Phosphorylation requires the presence of a functional (phosphorylated) FGFR1 and not necessarily by means of FGFR heterodimerization By similarity.
      SEQUENCE SIMILARITIES: Belongs to the protein kinase superfamily. Tyr protein kinase family. Fibroblast growth factor receptor subfamily.
      Contains 3 Ig-like C2-type (immunoglobulin-like) domains.
      Contains 1 protein kinase domain.
      Molecular WeightApproximately 115/125 kDa
      Physicochemical Information
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      Product Usage Statements
      Quality AssuranceEvaluated by Western Blot in mouse lung tissue lysate.
      Western Blot Analysis: A 1:1000 dilution of this antibody detected FGFR4 on mouse lung tissue lysate.
      Usage Statement
      • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
      Storage and Shipping Information
      Storage ConditionsMaintain refrigerated at 2-8°C for up to 12 months.
      Packaging Information
      Material Size100 µg
      Transport Information
      Supplemental Information
      Specifications
      Global Trade Item Number
      Catalogue Number GTIN
      07-2112 04053252473593