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115500 Adenophostin A, Hexasodium Salt - Calbiochem

Adenophostin A, Hexasodium Salt, is a potent agonist of type 1 inositol 1,4,5-trisphosphate receptor (InsP3R; EC50 = 10.9 nM). Exhibits about 50- to 100-fold greater affinity for IP3R than IP3.

Adenophostin A, Hexasodium Salt - Calbiochem MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.
Primary Target: Type 1 inositol 1,4,5-trisphosphate receptor (InsP3R)
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115500
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Overview

Replacement Information

Key Spec Table

Empirical Formula
C₁₆H₂₀N₅O₁₈P₃ · 6Na

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115500-50UGCN
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      Description
      OverviewOne of the most potent known agonist of type 1 inositol 1,4,5-trisphosphate receptor (InsP3R; EC50 = 10.9 nM). Exhibits about 50- to 100-fold greater affinity for IP3R than IP3. Stimulates Ca2+ release from Ins(1,4,5)P3-sensitive Ca2+ stores in microsomal preparations, permeabilized cells, and lipid vesicles containing purified InsP3R (EC50 = 14.7 nM for Ca2+ release from permeabilized hepatocytes). Does not bind to Ins(1,3,4,5)P4 binding sites and is resistant to enzymatic degradation.
      Catalogue Number115500
      Brand Family Calbiochem®
      References
      ReferencesCorrea, V., et al. 2001. Mol. Pharmacol. 59, 1206.
      Marchant, J.S., and Taylor, C.W. 1998. Biochemistry 37, 11524.
      DeLisle, S., et al. 1997. J. Biol. Chem. 272, 9956.
      Hartzell, H.C., et al. 1997. Mol. Pharmacol. 51, 683.
      Marchant, J.S., et al. 1997. Biochemistry 36, 12780.
      Hirota, J., et al. 1995. FEBS Lett. 368, 248.
      Takahashi, M., et al. 1994. J. Biol. Chem. 269, 369.
      Product Information
      ATP CompetitiveN
      FormWhite solid
      Hill FormulaC₁₆H₂₀N₅O₁₈P₃ · 6Na
      Chemical formulaC₁₆H₂₀N₅O₁₈P₃ · 6Na
      Hygroscopic Hygroscopic
      ReversibleN
      Structure formula ImageStructure formula Image
      Quality LevelMQ100
      Applications
      ApplicationAdenophostin A, Hexasodium Salt, is a potent agonist of type 1 inositol 1,4,5-trisphosphate receptor (InsP3R; EC50 = 10.9 nM). Exhibits about 50- to 100-fold greater affinity for IP3R than IP3.
      Biological Information
      Primary TargetType 1 inositol 1,4,5-trisphosphate receptor (InsP3R)
      Primary Target IC<sub>50</sub>EC50 = 10.9 nM against InsP3R
      Purity≥90% by HPLC
      Physicochemical Information
      Cell permeableN
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      Product Usage Statements
      Storage and Shipping Information
      Ship Code Ambient Temperature Only
      Toxicity Standard Handling
      Storage -20°C
      Hygroscopic Hygroscopic
      Do not freeze Ok to freeze
      Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable up to 3 months at -20°C.
      Packaging Information
      Transport Information
      Supplemental Information
      Specifications
      Global Trade Item Number
      Catalogue Number GTIN
      115500-50UGCN 07790788060244

      Documentation

      Adenophostin A, Hexasodium Salt - Calbiochem Certificates of Analysis

      TitleLot Number
      115500

      References

      Reference overview
      Correa, V., et al. 2001. Mol. Pharmacol. 59, 1206.
      Marchant, J.S., and Taylor, C.W. 1998. Biochemistry 37, 11524.
      DeLisle, S., et al. 1997. J. Biol. Chem. 272, 9956.
      Hartzell, H.C., et al. 1997. Mol. Pharmacol. 51, 683.
      Marchant, J.S., et al. 1997. Biochemistry 36, 12780.
      Hirota, J., et al. 1995. FEBS Lett. 368, 248.
      Takahashi, M., et al. 1994. J. Biol. Chem. 269, 369.

      Brochure

      Title
      Inorganics & Solvents for classical analysis
      Safety Connects - Solvents Withdrawal System Brochure
      Data Sheet

      Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

      Revision07-April-2008 RFH
      DescriptionA glyconucleotide originally isolated from the culture broth of Penicillium brevicompactum. Adenophostin A is the most potent known agonist of type 1 inositol 1,4,5-trisphosphate receptor (InsP3R). Exhibits about 50-100 fold greater affinity for the InsP3R than IP3. Stimulates Ca2+ release from Ins(1,4,5)P3-sensitive Ca2+ stores in microsomal preparations, permeabilized cells, and lipid vesicles containing purified InsP3R. Does not bind to Ins(1,3,4,5)P4 binding sites and is resistant to degradation by the enzymes that metabolize (1,4,5)InsP3.
      FormWhite solid
      Chemical formulaC₁₆H₂₀N₅O₁₈P₃ · 6Na
      Structure formulaStructure formula
      Purity≥90% by HPLC
      SolubilityH₂O (1 mg/ml)
      Storage -20°C
      Hygroscopic
      Do Not Freeze Ok to freeze
      Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable up to 3 months at -20°C.
      Toxicity Standard Handling
      ReferencesCorrea, V., et al. 2001. Mol. Pharmacol. 59, 1206.
      Marchant, J.S., and Taylor, C.W. 1998. Biochemistry 37, 11524.
      DeLisle, S., et al. 1997. J. Biol. Chem. 272, 9956.
      Hartzell, H.C., et al. 1997. Mol. Pharmacol. 51, 683.
      Marchant, J.S., et al. 1997. Biochemistry 36, 12780.
      Hirota, J., et al. 1995. FEBS Lett. 368, 248.
      Takahashi, M., et al. 1994. J. Biol. Chem. 269, 369.

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      Categories

      Life Science Research > Inhibitors and Biochemicals > Small Molecules & Inhibitors > Calcium Signaling > IP3 and Ryanodine Channel Modulators