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565792 γ-Secretase Inhibitor XXIII, Aβ42-Selective - Calbiochem

Overview

Key Spec Table

Empirical Formula
C₃₀H₃₉N₇O

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565792-5MGCN
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      Glass bottle 5 mg
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      Description
      OverviewA cell-permeable purine compound that acts as a highly potent and selective inhibitor against γ-secretase-mediated production of Aβ42 over Aβ40 (IC50 = 21 and 350 nM, respectively) and Notch1 (Notch IC50/ Aβ42 IC50 >2400) in cultures in vitro. Reported to be blood-brain barrier-permeant and orally bioavailable in APP-YAC transgenic mice and effectively reduce Aβ42 (by 73%), but not Aβ40, level in brain (100 mg/kg, p.o.) in vivo.
      Catalogue Number565792
      Brand Family Calbiochem®
      References
      ReferencesRivkin, A., et al. 2010. Bioorg. Med. Chem. Lett. 20, 2279.
      Product Information
      FormBeige solid
      Hill FormulaC₃₀H₃₉N₇O
      Chemical formulaC₃₀H₃₉N₇O
      Structure formula ImageStructure formula Image
      Quality LevelMQ100
      Biological Information
      Purity≥95% by HPLC
      Storage and Shipping Information
      Ship Code Shipped at Ambient Temperature or with Blue Ice or with Dry Ice
      Toxicity Standard Handling
      Storage +2°C to +8°C
      Protect from Light Protect from light
      Do not freeze Ok to freeze
      Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 2 months at -20°C.
      Packaging Information
      Packaged under inert gas Packaged under inert gas
      Global Trade Item Number
      Catalogue Number GTIN
      565792-5MGCN 04055977191882