Millipore Sigma Vibrant Logo
 

Magna Chip2


612 Results Búsqueda avanzada  
Mostrar
Productos (0)
Documentos (599)
Páginas (13)

Acote sus resultados Utilice los filtros siguientes para refinar su búsqueda

Tipo de documento

  • (566)
  • (16)
  • (11)
  • (3)
  • (2)
  • Mostrar más
¿No encuentra lo que está buscando?
Póngase en contacto con
el Servicio de Atención
al Cliente

 
¿Necesita ayuda para encontrar un documento?

  • Magna ChIP-Seq™ Kit

    Tipo de documento:
    Folleto
    Referencia del producto:
    Múltiplo
    Nombre del producto:
    Múltiplo

  • Regulation of pyruvate dehydrogenase kinase isoform 4 (PDK4) gene expression by glucocorticoids and insulin. 19703515

    The pyruvate dehydrogenase complex (PDC) catalyzes the conversion of pyruvate to acetyl-CoA in mitochondria and is a key regulatory enzyme in the oxidation of glucose to acetyl-CoA. Phosphorylation of PDC by the pyruvate dehydrogenase kinases (PDK) inhibits its activity. The expression of the pyruvate dehydrogenase kinase 4 (PDK4) gene is increased in fasting and other conditions associated with the switch from the utilization of glucose to fatty acids as an energy source. Transcription of the PDK4 gene is elevated by glucocorticoids and inhibited by insulin. In this study, we have investigated the factors involved in the regulation of the PDK4 gene by these hormones. Glucocorticoids stimulate PDK4 through two glucocorticoid receptor (GR) binding sites located more than 6000 base pairs upstream of the transcriptional start site. Insulin inhibits the glucocorticoid induction in part by causing dissociation of the GR from the promoter. Previously, we found that the estrogen related receptor alpha (ERRalpha) stimulates the expression of PDK4. Here, we determined that one of the ERRalpha binding sites contributes to the insulin inhibition of PDK4. A binding site for the forkhead transcription factor (FoxO1) is adjacent to the ERRalpha binding sites. FoxO1 participates in the glucocorticoid induction of PDK4 and the regulation of this gene by insulin. Our data demonstrate that glucocorticoids and insulin each modulate PDK4 gene expression through complex hormone response units that contain multiple factors.
    Tipo de documento:
    Referencia
    Referencia del producto:
    17-610
    Nombre del producto:
    Magna ChIP™ A - Chromatin Immunoprecipitation Kit

  • Magna ChIP™ Protein A -2686953

    Tipo de documento:
    Certificado de análisis
    Número de lote:
    2686953
    Referencia del producto:
    16-282
    Nombre del producto:
    Anti-Phosphotyrosine Antibody, clone 4G10®, Magnetic Bead Conjugate