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516560 Pertussis Toxin, Bordetella pertussis - CAS 70323-44-3 - Calbiochem

This Pertussis toxin, CAS 70323-44-3, catalyzes ADP-ribosylation of guanine nucleotide-binding regulatory proteins Gi, Go, and Gt.

Ficha de datos de seguridad (MSDS o SDS), certificado de análisis y de calidad (CoA y CoQ), expedientes, folletos y otros documentos disponibles.

Sinónimos: Islet-activating Protein

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516560
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CAS #
70323-44-3

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516560-50UG
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      Description
      OverviewObtain a uniform suspension before use. A protein endotoxin that catalyzes ADP-ribosylation of guanine nucleotide-binding regulatory proteins Gi, Go, and Gt. Used in the study of adenylate cyclase regulation and the role of Gi proteins. Holotoxin activity is determined in a CHO cell assay.
      NOTE: This product is not activated, hence for use in cell-free systems, activation is required.
      Catalogue Number516560
      Brand Family Calbiochem®
      SynonymsIslet-activating Protein
      References
      ReferencesJoshi, S.A., et al. 1998. FEBS Lett. 441, 67.
      Fryer, M.W. 1992. Neurosci. Lett. 146, 84.
      Gierschik, P. 1992. Curr. Topics Microbiol. Immunol. 175, 69.
      Harada, J., et al. 1992. Eur. J. Pharmacol. 227, 301.
      Hausman, S.Z., and Burns, D.L. 1992. J. Biol. Chem. 267, 13735.
      Kaslow, H.R., and Burns, D.L., 1992. FASEB J. 6, 2684.
      Zhu, J., et al. 1992. J. Pharmacol. Exp. Therap. 263, 1479.
      Hewlett, E.L., et al. 1983. Infect. Immun. 40, 1198.
      Moss, J., et al. 1983. J. Biol. Chem. 258, 11879.
      Product Information
      CAS number70323-44-3
      ATP CompetitiveN
      FormLyophilized
      FormulationLyophilized from 50 mM NaCl, 10 mM sodium phosphate buffer, pH 7.0.
      ReversibleN
      Quality LevelMQ100
      Biological Information
      Primary TargetGuanine nucleotide-binding regulatory proteins Gi, Go, and Gt
      PurityFive distinct bands by SDS-PAGE
      Physicochemical Information
      Cell permeableN
      ContaminantsAdenylate cyclase activity: ≤35 pmol/min/µg in the presence of calmodulin
      Safety Information according to GHS
      RTECSXW5883750
      Safety Information
      R PhraseR: 23/24/25

      Toxic by inhalation, in contact with skin and if swallowed.
      S PhraseS: 36/37/39-45

      Wear suitable protective clothing, gloves and eye/face protection.
      In case of accident or if you feel unwell, seek medical advice immediately (show the label where possible).
      Storage and Shipping Information
      Ship Code Ambient Temperature Only
      Toxicity Toxic
      Hazardous Materials Attention: Due to the nature of the Hazardous Materials in this shipment, additional shipping charges may be applied to your order. Certain sizes may be exempt from the additional hazardous materials shipping charges. Please contact your local sales office for more information regarding these charges.
      Storage +2°C to +8°C
      Do not freeze Yes
      Special InstructionsFollowing reconstitution, refrigerate (4°C). For long-term storage in solution, reconstitute with a high ionic strength buffer, such as 100 mM sodium phosphate, 500 mM sodium chloride, pH 7.0. Stock solutions are stable for at least 6 months for use in CHO cell assays and for 1-2 months for use in non-cellular systems.
      Global Trade Item Number
      Número de referencia GTIN
      516560-50UG 04055977198157