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553211 InSolution™ Rapamycin - Calbiochem

This product can no longer be ordered through emdmillipore.com. Please refer to (Cat. No. 553211) on sigmaaldrich.com.

InSolution™ Rapamycin - Calbiochem: Ficha de datos de seguridad (MSDS o SDS), certificado de análisis y de calidad (CoA y CoQ), expedientes, folletos y otros documentos disponibles.

Sinónimos: mTOR Inhibitor I

Primary Target: Mammalian target of rapamycin (mTOR)
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553211
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Descripción

Replacement Information

Tabla espec. clave

Empirical Formula
C₅₁H₇₉NO₁₃

Precios y disponibilidad

Número de referencia DisponiblidadEmbalaje Cant./Env. Precio Cantidad
553211-1MG
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      		 Ampolla de plást. 1 mg
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      553211-500UG
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      Ingrese cantidad 
      Suspendido
      Cantidades limitadas disponibles
      Debe confirmarse disponibilidad
        El resto: se avisará
          El resto: se avisará
          Se avisará
          Póngase en contacto con el Servicio de Atención al Cliente
          Contact Customer Service

          		 Ampolla de plást. 500 μg
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          No pudo obtenerse el precio
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          Description
          Catalogue Number553211
          Brand Family Calbiochem®
          SynonymsmTOR Inhibitor I
          References
          Product Information
          ATP CompetitiveN
          FormLiquid
          FormulationA 5 mM (500 µg/109 µl) solution of Rapamycin (Cat. No. 553210) in DMSO.
          Hill FormulaC₅₁H₇₉NO₁₃
          Chemical formulaC₅₁H₇₉NO₁₃
          Hygroscopic Hygroscopic
          ReversibleN
          Structure formula ImageStructure formula Image
          Quality LevelMQ100
          Applications
          Biological Information
          Primary TargetMammalian target of rapamycin (mTOR)
          Primary Target IC<sub>50</sub>50 pM inhibiting the mammalian target of rapamycin (mTOR) and blocking the subsequent activation of p70 S6 kinase
          Purity≥98% by TLC
          Physicochemical Information
          Cell permeableN
          Dimensions
          Materials Information
          Toxicological Information
          Safety Information according to GHS
          Safety Information
          Product Usage Statements
          Storage and Shipping Information
          Ship Code Shipped with Blue Ice or with Dry Ice
          Toxicity Irritant
          Storage -20°C
          Protect from Light Protect from light
          Hygroscopic Hygroscopic
          Do not freeze Ok to freeze
          Special InstructionsFollowing initial use, aliquot and freeze (-20°C).
          Packaging Information
          Packaged under inert gas Packaged under inert gas
          Transport Information
          Supplemental Information
          Specifications
          Global Trade Item Number
          Número de referencia GTIN
          553211-1MG 04055977193541
          553211-500UG 04055977193558

          Documentation

          InSolution™ Rapamycin - Calbiochem Ficha datos de seguridad (MSDS)

          Título

          Ficha técnica de seguridad del material (MSDS) 

          InSolution™ Rapamycin - Calbiochem Certificados de análisis

          CargoNúmero de lote
          553211

          Citas

          Título
        • Yung-Luen Yu, et al. (2005) MAP kinase-mediated phosphorylation of GATA-1 promotes Bcl-XL expression and cell survival. Journal of Biological Chemistry 280, 29533-29542.
        • Rick B. Vega, et al. (2004) Protein Kinases C and D Mediate Agonist-Dependent Cardiac Hypertrophy through Nuclear Export of Histone Deacetylase 5. Molecular and Cellular Biology 24, 8374-8385.
        • Xinbo Liao, et al. (2003) Androgen stimulates matrix metalloproteinase-2 expression in human prostate cancer. Endocrinology 144, 1656-1663.
          		•
          Ficha técnica

          Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

          Revision09-September-2008 RFH
          SynonymsmTOR Inhibitor I
          DescriptionSelectively inhibits the phosphorylation and activation of p70 S6 kinase (IC50 = 50 pM). Prevents the translational activation of IGF-II. Also prevents resting T-cells from entering the cell cycle, but does not directly arrest cell cycle progression. Shown to inhibit later signaling events, such as p110Rb phosphorylation, p34cdc2 kinase activation, and cyclin A synthesis. Exhibits strong binding to FK-506 binding proteins. Also reported to induce apoptosis in a murine B-cell line, to inhibit lymphokine-induced cell proliferation at the G1 phase, and to irreversibly arrest Saccharomyces cerevisiae cells in the G1 phase.
          FormLiquid
          FormulationA 5 mM (500 µg/109 µl) solution of Rapamycin (Cat. No. 553210) in DMSO.
          Intert gas (Yes/No) Packaged under inert gas
          Chemical formulaC₅₁H₇₉NO₁₃
          Structure formulaStructure formula
          Purity≥98% by TLC
          Storage Protect from light
          -20°C
          Hygroscopic
          Do Not Freeze Ok to freeze
          Special InstructionsFollowing initial use, aliquot and freeze (-20°C).
          Toxicity Irritant
          Citation
        • Yung-Luen Yu, et al. (2005) MAP kinase-mediated phosphorylation of GATA-1 promotes Bcl-XL expression and cell survival. Journal of Biological Chemistry 280, 29533-29542.
        • Rick B. Vega, et al. (2004) Protein Kinases C and D Mediate Agonist-Dependent Cardiac Hypertrophy through Nuclear Export of Histone Deacetylase 5. Molecular and Cellular Biology 24, 8374-8385.
        • Xinbo Liao, et al. (2003) Androgen stimulates matrix metalloproteinase-2 expression in human prostate cancer. Endocrinology 144, 1656-1663.
          		•