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MABF1727 Anti-CD4 (human), violetFluor™ 450, clone RPA-T4 Antibody

This mouse monoclonal Anti-CD4 Antibody (human), violetFluor™ 450, clone RPA-T4, Cat. No. MABF1727 is validated for use in Flow Cytometry, for the detection of CD4.

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Research Category: Inflammation & Immunology Research Sub-Category: Immunoglobulins & Immunology Gene Symbol: CD4 UniProt Number: P01730
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MABF1727
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      Tabla espec. clave

      Species ReactivityKey ApplicationsHostFormatAntibody Type
      HFCMvioletFluor™ 450Monoclonal Antibody
      Description
      Catalogue NumberMABF1727
      DescriptionAnti-CD4 (human), violetFluor™ 450, clone RPA-T4 Antibody
      Alternate Names
      • T-cell surface glycoprotein CD4
      • T-cell surface antigen T4/Leu-3
      • CD antigen CD4
      • CD4
      Background InformationThe RPA-T4 antibody reacts with human CD4, a 59 kDa protein which acts as a co-receptor for the T cell receptor (TCR) in its interaction with MHC Class II molecules on antigen-presenting cells. The extracellular domain of CD4 binds to the beta-2 domain of MHC Class II, while its cytoplasmic tail provides a binding site for the tyrosine kinase lck, facilitating the signaling cascade that initiates T cell activation. CD4, and co-receptors CCR5 and CXCR4, may also be utilized by HIV-1 to enter T cells. Human CD4 is typically expressed on thymocytes, some mature T cell populations such as Th17 and T regulatory (Treg) cells, as well as on dendritic cells.The RPA-T4 antibody is widely used as a phenotypic marker for human CD4 expression, and is cross-reactive with Chimpanzee CD4. This antibody recognizes a different epitope, and thus does not block binding of the alternative Anti-Human CD4 antibody clone OKT4 (Reinherz EL, et al. 1979. Proc. Natl. Acad. Sci. 76:4061-4065).
      References
      Product Information
      FormatvioletFluor™ 450
      PresentationPurified Mouse monoclonal containing 10 mM NaH2PO4, 150 mM NaCl, 0.09% NaN3, 0.1% gelatin, pH7.2.
      Quality LevelMQ100
      Applications
      ApplicationThis mouse monoclonal Anti-CD4 Antibody (human), violetFluor™ 450, clone RPA-T4, Cat. No. MABF1727 is validated for use in Flow Cytometry, for the detection of CD4.
      Key Applications
      • Flow Cytometry
      Biological Information
      ImmunogenImmunogen information for this antibody is proprietary information.
      CloneRPA-T4
      ConcentrationPlease refer to lot specific datasheet.
      HostMouse
      Species Reactivity
      • Human
      Antibody TypeMonoclonal Antibody
      Gene Symbol
      • CD4
      Purification MethodPurified by size-exclusion chromatography
      UniProt Number
      Physicochemical Information
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      Product Usage Statements
      Quality AssuranceThis monoclonal antibody was purified from tissue culture supernatant via affinity chromatography. The purified antibody was conjugated under optimal conditions, with unreacted dye removed from the preparation.

      Flow Cytometry Analysis: 0.25 μg from a representative lot detected CD4 in one million human peripheral blood lymphocytes.
      Usage Statement
      • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
      Storage and Shipping Information
      Storage ConditionsStable for 1 year at 2-8°C from date of receipt.
      Note: It is recommended to store the product undiluted at 2-8°C and protected from prolonged exposure to light. Do not freeze.
      Packaging Information
      Material Size25 tests
      Transport Information
      Supplemental Information
      Specifications
      Global Trade Item Number
      Número de referencia GTIN
      MABF1727 04055977290288

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      Categorías

      Life Science Research > Antibodies and Assays > Primary Antibodies