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MABF418 Anti-CD4 Antibody (human), PerCP-Cy5.5, clone OKT4

This mouse monoclonal antibody Anti-CD4 (human), PerCP-Cy5.5, clone OKT4 validated for use in western blotting, IP, ICC, Immunofluorescence & Flow Cytometry for the detection of CD4.

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Research Category: Inflammation & Immunology Gene Symbol: CD4 UniProt Number: P01730
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MABF418
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      Tabla espec. clave

      Species ReactivityKey ApplicationsHostFormatAntibody Type
      HFC, ICC, IHC, IP, WBMPerCP-Cy5.5Monoclonal Antibody
      Description
      Catalogue NumberMABF418
      DescriptionAnti-CD4 Antibody (human), PerCP-Cy5.5, clone OKT4
      Alternate Names
      • T-cell surface glycoprotein CD4
      • T-cell surface antigen T4/Leu-3
      • CD antigen CD4
      Background InformationThe OKT4 antibody reacts with human CD4, a 59 kDa protein which acts as a co-receptor for the T cell receptor (TCR) in its interaction with MHC Class II molecules on antigen-presenting cells. The extracellular domain of CD4 binds to the beta-2 domain of MHC Class II, while its cytoplasmic tail provides a binding site for the tyrosine kinase lck, facilitating the signaling cascade that initiates T cell activation. CD4, and co-receptors CCR5 and CXCR4, may also be utilized by HIV-1 to enter T cells. Human CD4 is typically expressed on thymocytes, some mature T cell populations such as Th17 and T regulatory (Treg) cells, as well as on dendritic cells.The OKT4 antibody is widely used as a phenotypic marker for CD4 expression. It is cross-reactive with CD4 in several non-human species, including Chimpanzee, Cynomolgus and Rhesus. This antibody recognizes a different epitope, and thus does not block binding of, the alternative Anti-Human CD4 antibody clone RPA-T4 (Reinherz EL, et al. 1979. Proc. Natl. Acad. Sci. 76:4061-4065)
      References
      Product Information
      FormatPerCP-Cy5.5
      PresentationPurified Mouse Monoclonal Antibody in buffer containing 10 mM NaH2PO4, 150 mM NaCl, 0.1% gelatin, pH 7.2, and up to 0.1% sodium azide.
      Quality LevelMQ100
      Applications
      ApplicationThis mouse monoclonal antibody Anti-CD4 (human), PerCP-Cy5.5, clone OKT4 validated for use in western blotting, IP, ICC, Immunofluorescence & Flow Cytometry for the detection of CD4.
      Key Applications
      • Flow Cytometry
      • Immunocytochemistry
      • Immunohistochemistry
      • Immunoprecipitation
      • Western Blotting
      Biological Information
      ImmunogenImmunogen information for this antibody is proprietary information.
      CloneOKT4
      Concentration5 µL (0.25 µg)/test
      HostMouse
      IsotypeIgG2bκ
      Species Reactivity
      • Human
      Antibody TypeMonoclonal Antibody
      Gene Symbol
      • CD4
      Purification MethodSize Exclusion Chromatography
      UniProt Number
      Physicochemical Information
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      Product Usage Statements
      Quality AssuranceThe monoclonal antibody was purified from tissue culture supernatant via affinity chromatography. The purified antibody was conjugated under optimal conditions, with unreacted dye removed from the preparation.

      Flow Cytometry Analysis: 0.25 µg of this antibody detected CD4 in one million human peripheral blood lymphocytes.
      Usage Statement
      • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
      Storage and Shipping Information
      Storage ConditionsIt is recommended to store the product undiluted at 2-8°C and protected from prolonged exposure to light. Do not freeze.
      Packaging Information
      Material Size100 tests
      Transport Information
      Supplemental Information
      Specifications
      Global Trade Item Number
      Número de referencia GTIN
      MABF418 04053252960093

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      Categorías

      Life Science Research > Antibodies and Assays > Primary Antibodies