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108219 Tris(hydroxymethyl)aminomethane hydrochloride

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MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.

Synonyms: Trometamol, Aminomethylidine trimethanol, 2-Amino-2-hydroxymethyl-1.3-propanediol, TRIS-buffer

CAS #: 1185-53-1 EC Number: 214-684-5 Molar Mass: 157.60 g/mol Chemical Formula: C₄H₁₁NO₃*ClH Hill Formula: C₄H₁₁NO₃˙ ClH
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108219
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Overview

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Key Spec Table

CAS #EC NumberHill FormulaChemical FormulaMolar Mass
1185-53-1214-684-5C₄H₁₁NO₃˙ ClHC₄H₁₁NO₃*ClH157.60 g/mol

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1082191000
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      1082199010
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          Description
          Catalogue Number108219
          SynonymsTrometamol, Aminomethylidine trimethanol, 2-Amino-2-hydroxymethyl-1.3-propanediol, TRIS-buffer
          DescriptionTris(hydroxymethyl)aminomethane hydrochloride
          References
          Product Information
          CAS number1185-53-1
          EC number214-684-5
          Hill FormulaC₄H₁₁NO₃˙ ClH
          Chemical formulaC₄H₁₁NO₃*ClH
          Molar Mass157.60 g/mol
          HS Code2922 19 99
          Structure formula ImageStructure formula Image
          Quality LevelMQ500
          Applications
          Biological Information
          Physicochemical Information
          Density1.28 g/cm3 (20.2 °C)
          Melting Point150.7 °C
          pH value4.2 (100 g/l, H₂O, 20 °C)
          Vapor pressure<0.1 hPa (50 °C)
          Solubility561 g/l soluble
          Dimensions
          Materials Information
          Toxicological Information
          Safety Information according to GHS
          Storage class10 - 13 Other liquids and solids
          WGKWGK 1 slightly hazardous to water
          Disposal3
          Relatively unreactive organic reagents should be collected in container A. If halogenated, they should be collected in container B. For solid residues use container C.
          Safety Information
          Product Usage Statements
          Storage and Shipping Information
          StorageStore at +15°C to +25°C.
          Packaging Information
          Transport Information
          Supplemental Information
          Specifications
          Appearancewhite to almost white, crystalline powder
          Assay (alkalimetric, calculated on dried substance)≥ 99.0 %
          Identity (IR-spectrum)conforms
          pH-value (0.5 mol/l, water)3.5 - 5.0
          Melting point147 - 153 °C
          UV-Absorption (230 nm; 10 %; 1 cm; water)≤ 0.1
          UV-Absorption (260 nm; 10 %, 1 cm; water)≤ 0.06
          UV-Absorption (280 nm; 10 %; 1 cm; water)≤ 0.06
          UV-Absorption (300 nm; 10 %; 1 cm; water)≤ 0.02
          UV-Absorption (400 nm; 10 %; 1 cm; water)≤ 0.01
          Residual solvents (ICHQ3C) of class 2 (Methanol)≤ 3000 ppm
          Residual solvents (ICHQ3C) of class 2 (Nitromethane)≤ 50 ppm
          Residual solvents (ICHQ3C) of class 3 (Ethanol)≤ 5000 ppm
          Residual solvents (ICHQ3C) of class 3 (Ethylmethylketon)≤ 5000 ppm
          Other residual solvents (ICH Q3C)excluded by manufacturing process
          Sulfated ash≤ 0.03
          Loss on Drying (105°C)≤ 0.5
          Endotoxins< 2.5
          Total aerobic microbial count≤ 10²
          Total yeast and mould count
          ≤ 10²
          Salmonella spp.
          absent in 10 g
          E.coli
          absent in 1 g
          Staphylococcus aureus
          absent in 1 g
          Pseudomonas aeruginosa
          absent in 1 g
          Candida albicans
          absent in 1 g
          Bile tolerante gram negative bacteria
          absent in 1 g
          DNases (Exo- and endonucleases)
          not detected
          Proteases
          not detected
          RNases
          not detected
          Elemental impurity specifications have been set considering ICH Q3D (Guideline for Elemental Impurities). Class 1-3 elements are not likely to be present above the ICH Q3D option 1 limit, unless specified and indicated (*).
          Total yeast and mould count
          ≤ 10²
          Salmonella spp.
          absent in 10 g
          E.coli
          absent in 1 g
          Staphylococcus aureus
          absent in 1 g
          Pseudomonas aeruginosa
          absent in 1 g
          Candida albicans
          absent in 1 g
          Bile tolerante gram negative bacteria
          absent in 1 g
          DNases (Exo- and endonucleases)
          not detected
          Proteases
          not detected
          RNases
          not detected
          Elemental impurity specifications have been set considering ICH Q3D (Guideline for Elemental Impurities). Class 1-3 elements are not likely to be present above the ICH Q3D option 1 limit, unless specified and indicated (*).
          Global Trade Item Number
          Catalogue Number GTIN
          1082191000 04022536101811
          1082199010 04022536702742

          Documentation

          Material Qualification Dossier

          TitleVersion
          6.0

          Quality Management Dossier (Open Access)

          Title

          Operational Excellence Dossier

          Title

          Tris(hydroxymethyl)aminomethane hydrochloride SDS

          Title

          Safety Data Sheet (SDS) 

          Tris(hydroxymethyl)aminomethane hydrochloride Certificates of Analysis

          Product Number PackagingSpecificationLot Number
          1082191000 Plastic bottlePDF Specification Document
          1082199010 Plastic drumPDF Specification Document

          Certificates

          Title