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324515 eEF-2 Kinase Inhibitor, NH125 - CAS 278603-08-0 - Calbiochem

The eEF-2 Kinase Inhibitor, NH125, also referenced under CAS 278603-08-0, controls the biological activity of eEF-2 Kinase. This small molecule/inhibitor is primarily used for Phosphorylation & De

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Synonyms: 1-Benzyl-3-cetyl-2-methylimidazolium iodide, 1-Cetyl-3-benzyl-2-methylimidazolium iodide, CaM-Dependent Kinase III Inhibitor, NH125

Primary Target: Bacterial histidine kinases (EnvZ, PhoQ, BvgS, and EvgS) and eukaryotic eEF-2 (elongation factor 2) kinase/CaMKIII
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324515
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Overview

Key Spec Table

CAS #Empirical Formula
278603-08-0C₂₇H₄₅IN₂

Products

Catalogue NumberPackaging Qty/Pack
324515-5MG Plastic ampoule 5 mg
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Description
OverviewA cell-permeable imidazolium compound that inhibits the activity of bacterial histidine kinases (EnvZ, PhoQ, BvgS, and EvgS) and eukaryotic eEF-2 (elongation factor 2) kinase/CaMKIII (IC50 = 60 nM), while exhibiting much lower potency against PKC, PKA, and CaMKII (IC50 = 7.5, 80, and >100 µM, respectively). NIH125 is a known P-gp substrate, which limits its in vivo efficacy as an anticancer and antimicrobial agent.
Catalogue Number324515
Brand Family Calbiochem®
Synonyms1-Benzyl-3-cetyl-2-methylimidazolium iodide, 1-Cetyl-3-benzyl-2-methylimidazolium iodide, CaM-Dependent Kinase III Inhibitor, NH125
References
ReferencesArora, S., et al. 2004. Mol. Pharmacol. 66, 460.
Arora, S., et al. 2003. Cancer Res. 63, 6894.
Yamamoto, K., et al. 2000. Biosci. Biotechnol. Biochem. 64, 919.
Product Information
CAS number278603-08-0
ATP CompetitiveN
FormWhite to yellow solid
Hill FormulaC₂₇H₄₅IN₂
Chemical formulaC₂₇H₄₅IN₂
Hygroscopic Hygroscopic
ReversibleN
Structure formula ImageStructure formula Image
Quality LevelMQ100
Biological Information
Primary TargetBacterial histidine kinases (EnvZ, PhoQ, BvgS, and EvgS) and eukaryotic eEF-2 (elongation factor 2) kinase/CaMKIII
Primary Target IC<sub>50</sub>60 nM against the activity of bacterial histidine kinases (EnvZ, PhoQ, BvgS, and EvgS) and eukaryotic eEF-2 (elongation factor 2) kinase/CaMKIII
Purity≥95% by NMR
Physicochemical Information
Cell permeableY
Safety Information
R PhraseR: 36/37/38

Irritating to eyes, respiratory system and skin.
S PhraseS: 26-36

In case of contact with eyes, rinse immediately with plenty of water and seek medical advice.
Wear suitable protective clothing.
Storage and Shipping Information
Ship Code Ambient Temperature Only
Toxicity Irritant
Storage +2°C to +8°C
Protect from Light Protect from light
Hygroscopic Hygroscopic
Do not freeze Ok to freeze
Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.
Packaging Information
Packaged under inert gas Packaged under inert gas
Global Trade Item Number
Catalogue Number GTIN
324515-5MG 04055977197303