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344036 cFMS Receptor Tyrosine Kinase Inhibitor - CAS 870483-87-7 - Calbiochem

Overview

Key Spec Table

CAS #Empirical Formula
870483-87-7C₂₀H₂₂N₄O₃

Products

Catalogue NumberPackaging Qty/Pack
344036-1MG Plastic ampoule 1 mg
Description
OverviewA cell-permeable diaminopyrimidine compound that acts as a potent, selective, and ATP-competitive inhibitor of cFMS kinase activity (IC50 = 30 nM) with minimal inhibition towards a panel of 26 other kinases (IC50 >5 µM). Shown to selectively inhibit cFMS-mediated cellular functions in vitro as well as CSF-1-dependent tumor growth in vivo. A 10 mM (1 mg/273 µl) solution of cFMS Receptor Tyrosine Kinase Inhibitor (Cat. No. 344041) in DMSO is also available.
Catalogue Number344036
Brand Family Calbiochem®
Synonyms5-(3-Methoxy-4-((4-methoxybenzyl)oxy)benzyl)-pyrimidine-2,4-diamine, CSF-1 Receptor Inhibitor, GW2580
References
ReferencesConway, J.G., et al. 2005. Proc. Natl. Acad. Sci. USA 102, 16078.
Product Information
CAS number870483-87-7
ATP CompetitiveY
FormOff-white solid
Hill FormulaC₂₀H₂₂N₄O₃
Chemical formulaC₂₀H₂₂N₄O₃
ReversibleN
Structure formula ImageStructure formula Image
Quality LevelMQ100
Biological Information
Primary TargetCFMS
Primary Target IC<sub>50</sub>30 nM against cFMS kinase activity
Purity≥97% by HPLC
Physicochemical Information
Cell permeableY
Storage and Shipping Information
Ship Code Ambient Temperature Only
Toxicity Standard Handling
Storage +2°C to +8°C
Protect from Light Protect from light
Do not freeze Ok to freeze
Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.
Packaging Information
Packaged under inert gas Packaged under inert gas
Global Trade Item Number
Catalogue Number GTIN
344036-1MG 04055977195149